Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining

Journal of Gene Medicine

Volumn 2, Issue 3, 2000, Pages 210-219

  Yao, Qingping ^a   Glorioso, Joseph C ^a   Evans, Christopher H ^a   Robbins, Paul D ^a   Kovesdi, Imre ^b   Oligino, Thomas J ^a,c   Ghivizzani, Steven C ^a,c,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b GENVEC INC   (United States)

^c Urigen Pharmaceuticals Inc   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Adenovirus; Apoptosis; Arthritis; Fas ligand; Gene therapy; Synovium

Indexed keywords

ADENOVIRIDAE; ORYCTOLAGUS CUNICULUS;

FAS LIGAND; FASLG PROTEIN, HUMAN; MEMBRANE PROTEIN;

ADENOVIRUS; ANIMAL; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CELL CULTURE; FIBROBLAST; GENE VECTOR; GENETICS; HUMAN; IN VITRO STUDY; KNEE; PATHOLOGY; RABBIT; RHEUMATOID ARTHRITIS; SYNOVIUM;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; CELLS, CULTURED; FAS LIGAND PROTEIN; FIBROBLASTS; GENETIC VECTORS; HUMANS; KNEE JOINT; MEMBRANE GLYCOPROTEINS; RABBITS; SYNOVIAL MEMBRANE;

EID: 0034181184     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-2254(200005/06)2:3<210::AID-JGM101>3.0.CO;2-P     Document Type: Article

References (43)

1. Rosen A, Weiland AJ. Rheumatoid arthritis of the wrist and hand. Rheum Dis Clin North Am 1998; 24: 101-128.
2. Sculco TP. The knee joint in rheumatoid arthritis. Rheum Dis Clin North Am 1998; 24: 143-156.
3. Laine VA. Early synovectomy in rheumatoid arthritis. Annu Rev Med 1967; 18: 173-184.
4. Deutsch E, Brodack JW, Deutsch KF. Radiation synovectomy revisited. Eur J Nucl Med 1993; 20: 1113-1127.
5. Taylor WJ, Corkill MM, Rajapaske CN. A retrospective review of yttrium-90 synovectomy in the treatment of knee arthritis. Br J Rheumatol 1997; 36: 1100-1105.
6. Menkes CJ. Is there a place for chemical and radiation synovectomy in rheumatic diseases? Rheumatol Rehabil 1979; 18: 65-77.
7. Hilliquin P, Le Devic P, Menkes CJ. Comparison of the efficacy of nonsurgical synovectomy (synoviorthesis) and joint lavage in knee osteoarthritis with effusions. Rev Rhum Engl Ed 1996; 63: 93-102.
8. Sant SM, Suarez TM, Moalli MR, et al. Molecular lysis of synovial lining cells by in vivo herpes simplex virus-thymidine kinase gene transfer. Hum Gene Ther 1998; 9: 2735-2743.
9. Goossens PH, Schouten GJ, Hart BA, et al. Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen induced arthritis-affected rhesus monkeys. Hum Gene Ther 1999; 10: 1139-1149.
10. Nita I, Ghivizzani SC, Galea-Lauri J, et al. Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 1996; 39: 820-828.
11. Roessler BJ, Allen ED, Wilson JM, et al. Adenoviral-mediated gene transfer to rabbit synovium in vivo. J Clin Invest 1993; 92: 1085-1092.
12. Yovandich J, O'Malley B Jr, Sikes M, et al. Gene transfer to synovial cells by intra-articular administration of plasmid DNA. Hum Gene Ther 1995; 6: 603-610.
13. Makarov SS, Olsen JC, Johnston WN, et al. Retrovirus mediated in vivo gene transfer to synovium in bacterial cell wall-induced arthritis in rats. Gene Ther 1995; 2: 424-428.
14. Ghivizzani SC, Lechman ER, Tio C, et al. Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther 1997; 4: 977-982.
15. Ju ST, Panka DJ, Gui H, et al. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation [see comments]. Nature 1995; 373: 444-448.
16. Kobayashi T, Okamoto K, Kobata T, et al. Apomodulation as a novel therapeutic concept for the regulation of apoptosis in rheumatoid synoviocytes. Curr Opin Rheumatol 1999; 11: 188-193.
17. Yu Q, Liu X, Shi G. Immunohistochemical study of Fas antigen expression in synovial tissues from patients with rheumatoid arthritis. Chin Med J (Engl) 1998; 111: 211-213.
18. Nakajima T, Aono H, Hasunuma T, et al. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 1995; 38: 485-491.
19. Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid arthritis synovium. J Clin Invest 1995; 96: 1631-1638.
20. Cantwell MJ, Hua T, Zvaifler NJ, et al. Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis [see comments]. Arthritis Rheum 1997; 40: 1644-1652.
21. Asahara H, Hasumuna T, Kobata T, et al. Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue. Clin Immunol Immunopathol 1996; 81: 27-34.
22. Zhang H, Yang Y, Horton JL, et al. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. J Clin Invest 1997; 100: 1951-1957.
23. Okamoto K, Asahara H, Kobayashi T, et al. Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Ther 1998; 5: 331-338.
24. Ghivizzani SC, Kang R, Georgescu HI, et al. Constitutive intraarticular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis. J Immunol 1997; 159: 3604-3612.
25. Yeh P, Perricaudet M. Advances in adenoviral vectors: from genetic engineering to their biology. FASEB J 1997; 11: 615-623.
26. Hitt M, Bett AJ, Prevec L, et al. Construction and propagation of human adenovirus vectors. In Construction and Propagation of Human Adenovirus Vectors, Cells J (ed.). New York: Academic Press. 1994: 479-490.
27. Graham FL, Van der Eb AJ. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973; 52: 456-467.
28. Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol 1996; 70: 7498-7509.
29. Enari M, Hug H, Nagata S. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 1995; 375: 78-81.
30. Ray CA, Black RA, Kronheim SR, et al. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 1992; 69: 597-604.
31. Muzio M, Salvesen GS, Dixit VM. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem 1997; 272: 2952-2956.
32. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, et al. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A 1996; 93: 14486-14491.
33. Tewari M, Dixit VM. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 1995; 270: 3255-3260.
34. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
35. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-277.
36. Georgescu HI, Mendelow D, Evans CH. HIG-82: an established cell line from rabbit periarticular soft tissue., which retains the "activatable" phenotype. In Vitro Cell Dev Biol Anim 1988; 24: 1015-1022.
37. Sakai K, Matsuno H, Morita I, et al. Potential withdrawal of rheumatoid synovium by the induction of apoptosis using a novel in vivo model of rheumatoid arthritis. Arthritis Rheum 1998; 41: 1251-1257.
38. Fujisawa K, Asahara H, Okamoto K, et al. Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice. J Clin Invest 1996; 98: 271-278.
39. Lechman ER, Jaffurs D, Ghivizzani SC, et al. Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol 1999; 163: 2202-2208.
40. Whalen JD, Lechman EL, Carlos CA, et al. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J Immunol 1999; 162: 3625-3632.
41. Ma Y, Thornton S, Duwel LE, et al. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol 1998; 161: 1516-1524.
42. Ghivizzani SC, Lechman ER, Kang R, et al. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc Natl Acad Sci U S A 1998; 95: 4613-4618.
43. Roessler BJ, Hartman JW, Vallance DK, et al. Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector. Hum Gene Ther 1995; 6: 307-316.