Pentoxifylline inhibits the synthesis and IFN-γ-inducing activity of IL-18

Clinical and Experimental Immunology

Volumn 124, Issue 2, 2001, Pages 274-281

  Samardzic, T ^a   Jankovic, V ^b   Stosic Grujicic, S ^a   Popadic, D ^b   Trajkovic, V ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Medical School   (Yugoslavia)

Author keywords

IFN ; IL 18; LPS; Mouse; Pentoxifylline

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; LIPOPOLYSACCHARIDE; MESSENGER RNA; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE EXPRESSION; INHIBITION KINETICS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; MICE; MICE, INBRED CBA; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; SIGNAL TRANSDUCTION; SPLEEN;

EID: 0034958208     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01546.x     Document Type: Article

References (46)

1. A newly defined interleukin-1?
2. Activation of interferon-γ-inducing factor mediated by interleukin-1β converting enzyme
3. Cloning of a new cytokine that induces IFN-γ production by T cells
4. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
5. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
6. Comparison of the effects of interleukin-1α, interleukin-1β and interferon-γ-inducing factor on the production of interferon-γ by natural killer
7. Defective NK cell activity and Th1 response in IL-18-deficient mice
8. IL-18 (IFN-γ-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice
9. In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection
10. IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-γ production
11. IFN-γ-inducing factor/IL-18 administration mediates IFN-γ- and IL-12-independent antitumor effects
12. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2
13. Neutralizing antibodies to IFN-γ-inducing factor prevent experimental autoimmune encephalo-myelitis
14. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
15. Role of interleukin-18 (IL-18) during lethal shock: Decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice
16. IFN-γ-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12
17. Interferon-γ, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice
18. Essential role for natural killer cells in the lethal lipopolysaccharide-induced Shwartzman-like reaction in mice
19. Interferon-γ receptor deficient mice are resistant to endotoxic shock
20. Pentoxifylline improves circulatory failure and survival in murine models of endotoxaemia
21. Pentoxifylline treatment of sepsis in conscious Yucatan minipigs
22. Inhibition of tumor necrosis factor production and ICAM-1 expression by pentoxifylline: Beneficial effects in sepsis syndrome
23. Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock
24. Production of proinflammatory cytokines and cytokines involved in the TH1/TH2 balance is modulated by pentoxifylline
25. Cellular and molecular regulation of tumor necrosis factor-α production by pentoxifylline
26. Cell-specific effects of pentoxifylline on nitric oxide production and inducible nitric oxide synthase mRNA expression
27. Reduction of background problems in nonradioactive Northern and Southern analyses enables higher sensitivity than 32P-based hybridisation
28. IL-12-induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor
29. A mechanism underlying the synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ
30. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production
31. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP 1 cells
32. IL-18 accounts for both TNF-α-and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice
33. Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury
34. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
35. Interleukin-12 is required for interferon-γ production lethality in lipopolysaccharide-induced shock in mice
36. Differential effects of pentoxifylline, a non-specific phosphodiesterase inhibitor, on the production of IL-10, IL-12 p40 and p35 subunits by murine peritoneal macrophages
37. Inhibition of human interleukin-12 production by pentoxifylline
38. The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice
39. Immune response modulation by pentoxifylline in vitro
40. Pentoxifylline: A potent inhibitor of IL-2 and IFN-γ biosynthesis and BCG-induced cytotoxicity
41. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
42. Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1- but not type 2-associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats
43. Elevation of IL-18 in human sepsis
44. Bioactive IL-18 expression is up-regulated in Crohn's disease
45. + human blood mononuclear cells
46. Interleukin-18/interferon-γ-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cells