Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2)

Pharmaceutical Research

Volumn 18, Issue 5, 2001, Pages 579-586

  Han, Y H ^a,b   Kato, Y ^a   Haramura, M ^c   Ohta, M ^c   Matsuoka, H ^c   Sugiyama, Y ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

cMOAT MRP2; Dynamic molecular surface area; Octanol water partition coefficient; Primary active transport; Substrate specificity

Indexed keywords

METHOTREXATE; METHOTREXATE DERIVATIVE;

ANIMAL EXPERIMENT; ANION TRANSPORT; ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME SPECIFICITY; MALE; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SURFACE PROPERTY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BILE CANALICULI; CHEMISTRY, PHYSICAL; KINETICS; LINEAR MODELS; MALE; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES;

EID: 0034957411     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011064806507     Document Type: Article

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