The adaptor protein shc is involved in the negative regulation of NK cell-mediated cytotoxicity

European Journal of Immunology

Volumn 31, Issue 7, 2001, Pages 2016-2025

  Galandrini, Ricciarda ^a   Tassi, Ilaria ^a   Morrone, Stefania ^b   Lanfrancone, Luisa ^b   Pelicci, Piergiuseppe ^a   Piccoli, Mario ^c   Frati, Luigi ^b   Santoni, Angela ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

Cytotoxicity; NK cell; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; CALCIUM ION; CD16 ANTIGEN; ESTERASE; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL PHOSPHATASE; LIGAND; PHOSPHATIDYLINOSITIDE; PROTEIN SHC; PROTEIN TYROSINE KINASE; SHIP PROTEIN; SRC HOMOLOGY 2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL INTERACTION; CELL KILLING; CELL LINE; CONTROLLED STUDY; CORRELATION FUNCTION; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOPRECIPITATION; IMMUNOREGULATION; LIGATION; MOUSE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RAT; TARGET CELL; ZETA CHAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CALCIUM SIGNALING; CELL LINE; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; K562 CELLS; KILLER CELLS, NATURAL; MACROMOLECULAR SUBSTANCES; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHOTYROSINE; PROTEINS; RECEPTORS, IGG; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 0034945821     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200107)31:7<2016::AID-IMMU2016>3.0.CO;2-W     Document Type: Article

References (50)

1. Biology of natural killer cells
2. Signal transduction during natural killer cell activation: Inside the mind of a killer
3. CD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells
4. Selective binding of shc-SH2 domain to tyrosine-phosphorylayed ζ-but not γ-chain upon CD16 ligation on human NK cells
5. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
6. Not all Shc's roads lead to Ras
7. Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc
8. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
9. P150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
10. Phosphatidylinositol 3'-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the granulocyte colony stimulating factor receptor
11. The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes
12. The SH2-containing 5'-inositol phosphatase (SHIP) is tyrosine phosphorylated after Fcγ receptor clustering in monocytes
13. Ptdlns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
14. The inositol polyphosphate 5-phosphatase SHIP is a crucial negative regulator of B cell antigen receptor signaling
15. 2+ oscillatory response
16. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation
17. SHIP modulates immune receptor responses by regulating membrane association of Btk
18. Altered responsiveness to chemokines due to targeted distruption of SHIP
19. The binding and lysis of target cells by cytotoxic lymphocytes: Molecular and cellular aspects
20. Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes
21. + induced in cytotoxic T lymphocytes by cellular antigen
22. Target-cell contact activates a highly selective capacitative calcium entry pathway in cytotoxic T lymphocytes
23. Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases
24. Inhibition of CD4/p56lck signaling by a dominant negative mutant of the shc adptor protein
25. The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner
26. Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner
27. Requirement for shc in TCR-mediated activation of a T cell hybridoma
28. Enzymatic activity of the SH2 domain-containing inositol phosphatase is regulated by a plasma membrane location
29. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
30. Negative signaling in B cell causes reduced Ras activity by reducing Shc-Grb2 interaction
31. B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein
32. Differential association of phosphatase with hematopoietic co-receptors bearing innunoreceptor tyrosine-based inhibition motifs
33. Interaction of shc with the 1562; chain of the T cell receptor upon T cell activation
34. The src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis
35. Activation-induced bidentate interaction of SHIP and shc in B lymphocytes
36. The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and respond to high affinity lgE receptor aggregation
37. The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated β subunit of the high affinity lgE receptor
38. Phosphatidylinositol-3,4,5-trisphosphate (Ptdlns-3,4,5-P3)/ Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
39. Activation of phospholipase C-γ by phosphatidylinositol 3,4,5-trisphosphate
40. Activation phospholipase Cγ by PI3-kinase-induced PH domain-mediated membrane targeting
41. The store-operated calcium current ICRAC: Nonlinear activation by InsP3 and dissociation from calcium release
42. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
43. Negative signaling pathways of the killer cell inhibitory receptor and FcγRIIb1 require distinct phosphatases
44. 2; CD11b/ CD18)
45. Formation of shc-grb2 complexes is necessary to induce neoplastic transformation by overexpression of shc proteins
46. Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia
47. Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity
48. High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescent protein
49. CD44 triggering enhances human NK cell cytotoxic functions
50. Intracellular ionized calcium