Impaired brachial artery endothelial function is not predicted by elevated triglycerides

Journal of the American College of Cardiology

Volumn 33, Issue 7, 1999, Pages 2038-2043

  Schnell, Greg B ^a   Robertson, Annette ^a   Houston, Deborah ^a   Malley, Linda ^a   Anderson, Todd J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL DIAMETER; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; VASODILATATION;

ADULT; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; CHOLESTEROL, HDL; CHOLESTEROL, LDL; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPERLIPIDEMIAS; MALE; NITROGLYCERIN; PREDICTIVE VALUE OF TESTS; TRIGLYCERIDES; ULTRASONOGRAPHY, DOPPLER, PULSED; VASODILATION; VASODILATOR AGENTS; VIDEO RECORDING;

EID: 0032720865     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(99)00104-7     Document Type: Article

References (42)

1. Celermajer D.S. Endothelial dysfunction: does it matter? Is it reversible? J Am Coll Cardiol. 30:1997;325-333.
2. Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288:1980;373-376.
3. Mellion B.T., Ignarro L.J., Ohlstein E.H., et al. Evidence for the inhibitory role of guanosine 3′5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilation. Blood. 57:1981;946-955.
4. Garg U.C., Hassid A. Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 83:1989;1774-1777.
5. Palmer R.M.J., Ferrige A.G., Moncada S. Nitric oxide accounts for the biologic activity of endothelium-dependent relaxing factor. Nature. 327:1987;524-526.
6. Joannides R., Haefeli W.E., Linder L., et al. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo. Circulation. 91:1995;1314-1319.
7. Ludmer P.L., Selwyn A.P., Shook T.L., et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 315:1986;1046-1051.
8. Creager M.A., Cooke J.P., Mendelsohn M.E., et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 86:1990;228-234.
9. Leung W.H., Lau C.P., Wong C.K. Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients. Lancet. 341:1993;1496-1500.
10. Jeppesen J., Hein H.O., Suadicani P., Gyntelberg F. Triglyceride concentration and ischemic heart disease. Circulation. 97:1998;1029-1036.
11. Manninen V., Tenkanen L., Koskinen P., et al. Joint effects of serum triglyceride and LDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Circulation. 85:1992;37-45.
12. Assmann G., Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Am J Cardiol. 70:1992;733-737.
13. Simon B.C., Cunningham L.D., Cohen R.A. Oxidized low density lipoproteins cause contraction and inhibit relaxation in the pig coronary artery. J Clin Invest. 86:1990;75-79.
14. Ohara Y., Peterson T.E., Harrison D.G. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 92:1993;2546-2551.
15. Flavahan N.A. Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity. Circulation. 85:1992;1927-1938.
16. Liao J.K., Shin W.S., Lee W.Y., Clark S.L. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem. 270:1995;319-324.
17. Anderson T.J., Meredith I.T., Charbonneau F., et al. Endothelium-dependent coronary vasomotion relates to the susceptibility of LDL to oxidation in humans. Circulation. 93:1996;1647-1650.
18. Grundy S.M. Small LDL, atherogenic dyslipidemia, and the metabolic syndrome. Circulation. 95:1997;1-4.
19. Rubanyi G.M., Romero C., Vanhoutte P.M. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol. 250:1986;1115-1119.
20. Poll U., Holtz J., Busse R., Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension. 8:1986;37-44.
21. Sinoway L.I., Hendrickson C., Davidson W.R. Jr, et al. Characteristics of flow-mediated brachial artery vasodilation in human subjects. Circ Res. 11:1989;187-191.
22. Nabel E.G., Selwyn A.P., Ganz P. Large coronary arteries in humans are responsive to changing blood flow an endothelium-dependent mechanism that fails in patients with atherosclerosis . J Am Coll Cardiol. 16:1990;349-356.
23. Feldman R.L., Pepine C.J., Conti C.R. Magnitude of dilatation of large and small coronary arteries by nitroglycerin. Circulation. 64:1981;324-333.
24. Anderson T.J., Overhiser R.W., Haber H., Charbonneau F. A comparative study of four anti-hypertensive agents on endothelial function in patients with coronary disease (abstr). J Am Coll Cardiol. 31:1998;327.
25. Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 340:1992;111-115.
26. Lewis G.F., Steiner G. Hypertriglyceridemia and its metabolic consequences as a risk factor for atherosclerotic cardiovascular disease in non-insulin-dependent diabetes mellitus. Diabetes/Metabolism Rev. 12:1996;37-56.
27. NIH Consensus Conference Triglyceride, High-Density Lipoprotein, and Coronary Heart Disease . JAMA. 269:1993;505-510.
28. Lundman P., Eriksson M., Schenck-Gustafsson K., et al. Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease. Circulation. 96:1997;3266-3268.
29. Chowienczyk P.J., Watts G.F., Wierzbicki A.S., et al. Preserved endothelial function in patients with severe hypertriglyceridemia and low functional lipoprotein lipase activity. J Am Coll Cardiol. 29:1997;964-968.
30. Vogel R.A., Coretti M.C., Plotnick G.D. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 79:1997;350-354.
31. Sorensen K.E., Celermajer D.S., Georgakopoulos D., et al. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein (a) level. J Clin Invest. 93:1994;50-55.
32. Clarkson P., Adams M.R., Powe A.J., et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest. 97:1996;1989-1994.
33. Heitzer T., Yla-Herttuala S., Luoma J., et al. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL. Circulation. 93:1996;1346-1353.
34. Johnstone M.T., Creager S.J., Scales K.M., et al. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 88:1993;2510-2516.
35. Celermajer D.S., Sorensen K.E., Bull C., et al. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol. 24:1994;1468-1474.
36. Anderson T.J., Meredith I.T., Yeung A.C., et al. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med. 332:1995;488-493.
37. Castelli W.P. Epidemiology of coronary heart disease. The Framingham Study. Am J Med. 76:(Suppl 2A):1984;4-12.
38. Lipid Research Clinics Primary Prevention Trial results. JAMA 1984;251:351-64.
39. Shepherd J., Cobbe S.M., Ford I., et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 333:1995;1301-1307.
40. Kuhn F.E., Mohler E.R., Satler L.F., et al. Effects of high-density lipoprotein on acetylcholine-induced coronary vasoreactivity. Am J Cardiol. 68:1991;1425-1430.
41. Karpe F., Steiner G., Uffelman K., et al. Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis. 106:1994;83-97.
42. Anderson T.J., Uehata A., Gerhard M.D., et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 26:1995;1235-1241.