Hematopoietic growth factor mimetics

Annals of the New York Academy of Sciences

Volumn 938, Issue , 2001, Pages 131-138

  Kaushansky, Kenneth ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Hematopoietic growth factor; Hematopoietic signal transduction; Mimetic receptor complexes; Peptide screening

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GLYCOPROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; ORGANIC COMPOUND; PEPTIDE LIBRARY; PROTEIN EMP1; PROTEIN EMP33; RECOMBINANT PROTEIN; STAT PROTEIN; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; BINDING SITE; CONFERENCE PAPER; FERMENTATION; GROWTH REGULATION; GROWTH STIMULATION; HEMATOPOIESIS; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

EID: 0034944334     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03582.x     Document Type: Conference Paper

References (14)

1. Small peptides as potent mimetics of the protein hormone erythropoietin
2. A small, nonpeptidyl mimic of granulocyte colony stimulating factor
3. Mimicry of erythropoietin by a nonpeptide molecule
4. Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 Å
5. Increased potency of an erythropoietin peptide mimetic through covalent dimerization
6. Peptide agonist of the thrombopoietin receptor as potent as the natural hormone
7. Immunogenicity of thrombopoietin mimetic peptide GW395058 in Balb/C mice and New Zealand White rabbits: Evaluation of the potential for thrombopoietin neutralizing antibody production in man
8. Pharmacokinetics and hematological effects of the PEGylated thrombopoietin peptide mimetic GW395058 in rats and monkeys after intravenous or subcutaneous administration
9. Binding in the growth hormone receptor complex
10. Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide
11. Efficiency of signaling through cytokine receptors depends critically on receptor orientation
12. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
13. Erythropoietin receptor activation by a ligand induced conformation change
14. An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation