LOD score exclusion analyses for candidate genes using random population samples

Annals of Human Genetics

Volumn 65, Issue 3, 2001, Pages 313-329

  Deng, H W ^a,b   Li, J ^a   Recker, R R ^c  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HUNAN NORMAL UNIVERSITY   (China)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; VITAMIN D RECEPTOR;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; FRACTURE; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETICS; HUMAN; INHERITANCE; OSTEOPOROSIS; PEDIGREE; POPULATION; PRIORITY JOURNAL; RANDOMIZATION; RELATIVE; RISK; SAMPLE; STATISTICAL MODEL;

ALLELES; COMPUTER SIMULATION; GENES, DOMINANT; GENES, RECESSIVE; GENOTYPE; HUMANS; LOD SCORE; MODELS, GENETIC; MODELS, STATISTICAL; OSTEOPOROSIS; RECEPTORS, CALCITRIOL; RECEPTORS, ESTROGEN;

EID: 0034943926     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0003480001008673     Document Type: Article

References (38)

1. Altshuler, D., Hirschhorn J. N., Klannemark M. & Lander E. S. (2000). The common PPARγPro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genet. 26, 76-80.
2. Armitage, P. & Berry G. (1987). Statistical methods in medical research. Oxford, Blackwell. UK.
3. Audi, L., Garcia-Ramirez, M. & Carrascosa, A. (1999). Ǵenetic determinants of Bone Mass. Hormone Research 51, 105-123.
4. Blum, K., Nobel, E. P. & Sheridan, P. J., et al. (1990). Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263, 2055-2060.
5. Blum, K., Noble, E. P. & Sheridan, P. J., et al. (1991). Association of the Al allele of the D2 Dopamine receptor gene with severe alcoholism. Alcohol 8, 409-416.
6. Chagnon, Y. C., Perusse, L. & Bouchard, C. (1998). The human obesity gene map: the 1997 update. Obes. Res. 5, 76-92.
7. Chakraborty, R. & Smouse, P. (1988). Recombination in haplotypes leads to biased estimates of admixture proportions in human populations. Proc. Natl. Acad. Sci. USA 85, 3071-3074.
8. Deng, H. W., Li, J., Li, J. L., Johnson, M., Gong, G. & Recker, R. R. (1999). Association of VDR and Estrogen Receptor Genotypes with Bone Mass in Postmenopausal Caucasian Women : Different Conclusions with Different Analyses and the Implications. Osteoporosis Intl. 9, 499-507.
9. Deng, H. W. & Chen, W. M. (2000). Re: 'Biased tests of association: comparison of allele frequencies when departing from Hardy-Weinberg proportions'. Am. J. Epidemiology 151, 335-357.
10. Deng, H. W., Chen, W. M., Recker, S., Stegman, M. R., Li, J. L., Davies, K. M., Zhou, Y., Deng, H. Y., Heaney, R. R. & Recker, R. R. (2000a). Genetic determination of Colles ' fractures and differential bone mass in women with and without Colles' fractures. J. Bone, and Mineral Research 15, 1243-1252.
11. Deng, H. W., Chen, W. M. & Recker, R. R. (2000b). QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations. Am. J. Hum. Genet. 66, 1027-1045.
12. Deng, H. W., Chen, W. M. & Recker, R. R. (2001). Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits. Genetics, 157, 885-897.
13. Edwards, J. H. (1980). Exclusion mapping. J. Med. Genet. 24, 539-543.
14. Eisman, J. A. (1995). Vitamin D receptor gene alleles and osteoporosis: An affirmative view. J. Bone. Miner. Res. 10, 1289-1293.
15. Gelernter, J., Goldman, D. & Risch, N. (1993). The Al allele at the D2 dopamine receptor gene and alcoholism. JAMA 269, 1673-1677.
16. Gennari, L., Becherini, L., Mansani, R., Masi, L., Falchetti, A., Morelli, A., Colli, E., Gonnelli, S., Cepollaro, C. & Brandi, M. L. (1999). Fokl polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal Italian women. J. Bone. Miner. Res. 14, 1379-86.
17. Gomez, C., Naves, M. L., Barrios, Y., Diaz, J. B., Fernandez, J. L., Salido, E., Torres, A. & Cannata, J. B. (1999). Vitamin D receptor gene polymorphisms, bone mass, bone loss and prevalence of vertebral fracture: differences in postmenopausal women and men. Osteoporosis Intl. 10, 175-82.
18. Gong, G., Stern, S., Cheng, S. C., Fong, F., Mordeson, N., Deng, H. W. & Recker R. R. (1999). On the association of bone mass density and Vitamin-D genotype polymorphisms. Osteoporosis Intl. 9, 55-64.
19. Hanis, C. L., Boerwinkle, E., Chakraborty, R., Ellsworth, D. L. & Bell, G. I. (1996). A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nature Genetics 13, 161-166.
20. Hartl, D. L. & Clark, A. G. (1989). Principles of population genetics. Sinauer Associates,
21. Sunderland, MA. Holden, C. (1994). A cautionary genetic tale: the sobering story of D2. Science 264, 1696-1697.
22. Houston, L. A., Grant, S. F., Reid, D. M. & Ralston, S. H. (1996). Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. Bone. 18, 249-52.
23. Khoury, M. J., Beaty, T. H. & Cohen, B. H. (1993). Fundamentals of Genetic Epidemiology Oxford University Press, NY.
24. Kruglyak, L. & Lander, E. S. (1995). Complete multipoint sib-pair analysis of qualitative and quantitaitve traits. Am. J. Hum. Genet. 57, 439-454.
25. Lander, E. S. & Schork, N. J. (1994). Genetic dissection of complex traits. Science 265, 2037-2048.
26. Lander, E. & Kruglyak, L. (1995). Genetic dissection of complex traits: guidelines for interpreting the reporting results. Nature Genetics 11, 241-247.
27. Lynch, M. & Spitze, K. (1994). Evolutionary genetics of Daphnia. Pp. 109-128 in Ecological Genetics, edited by Real L, Princeton University Press, Princeton, NJ.
28. Morton, N. E., Collins, A. (1999). Tests and estimates of allelic association in complex inheritance Proc. Natl. Acad. Sci. USA 95, 11389-11393.
29. Nei, M. (1987). Molecular population genetics and evolution. North-Holland/American Elsevier, Amsterdam.
30. Ott, J. (1999). Analysis of human genetic linkage. 3rd Ed. Johns Hopkins University Press, Baltimore.
31. Pato, C. N., Macciardi, F., Pato, M. T., et al (1993). Review of the putative association of dopamine D2 receptor and alcoholism: a meta-analysis. Am. J. Med. Genet. 48, 78-82.
32. Peacock, M. (1995). Vitamin D receptor gene alleles and osteoporosis: A contrasting view. J. Bone. Miner. Res. 10, 1294-1297.
33. Pritchard, J. K., Stephens M., Rosenherg N. A. • Donnelly P. (2000). Association mapping in structured populations. Am J Hum Genet. 67, 170-181.
34. Risch, N. • Teng, J. (1998). The relative power of famity-based and case-control designs for linkage disequilibrium studies of complex human diseases. I. DNA polling. Genome Research 8, 1273-1288.
35. Spielman, R. S., McGinnis, R. E. • Ewens, W. J. (1993). Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506-510.
36. Vandevyver, C., Vanhoof, J., Declerck, K., Stinissen, P., Vandervorst, C., Michiels, L., Cassiman, J. J., Boonen, S., Raus, J., Geusens, P. (1999). Lack of association between estrogen receptor genotypes and bone mineral density, fracture history, or muscle strength in elderly women. J. Bone. Miner. Res. 14, 1576-82.
37. Weir, B. S. (1996). Genetic data analysis II. Sinauer, Sunderland, MA.
38. Wolfram, S. (1996). The Mathemalica. Wolfram Research, Inc., Champaign, IL.