FokI polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal italian women

Journal of Bone and Mineral Research

Volumn 14, Issue 8, 1999, Pages 1379-1386

  Gennari, Luigi ^a   Becherini, Lucia ^a   Mansani, Riccardo ^a   Masi, Laura ^a   Falchetti, Alberto ^a   Morelli, Annamaria ^a   Colli, Emanuela ^a   Gonnelli, Stefano ^b   Cepollaro, Chiara ^b   Brandi, Maria Luisa ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BONE ATROPHY; BONE DENSITY; CALCIUM INTAKE; CONTROLLED STUDY; DENSITOMETRY; FEMALE; FEMUR NECK; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LUMBAR VERTEBRA; MAJOR CLINICAL STUDY; OSTEOPENIA; OSTEOPOROSIS; POSTMENOPAUSE; TRANSLATION INITIATION; VERTEBRA FRACTURE;

AGED; ANALYSIS OF VARIANCE; BONE DENSITY; BONE DISEASES, METABOLIC; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; GENOTYPE; HUMANS; ITALY; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; POLYMORPHISM, GENETIC; POSTMENOPAUSE; RECEPTORS, CALCITRIOL; SPINAL FRACTURES;

EID: 0032812623     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.8.1379     Document Type: Article

References (33)

1. Smith DM, Nance WE, Kang KW, Christian JC, Johnston CC 1972 Genetic factors in determining bone mass. J Clin Invest 52:2800-2808.
2. Hansen MA, Hassager C, Jensen SB, Christiansen C 1992 Is heritability a risk factor for postmenopausal osteoporosis? J Bone Miner Res 7:1037-1043.
3. Seeman E, Hopper JL, Bach LA, Cooper ME, Parkinson E, McKay J, Jerums G 1989 Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 320:554-558.
4. Morrison NA, Cheng JQI, Akifumi T, Kelly PJ, Krofts L, Nguyen TV, Sambrook PN, Eisman JA 1994 Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287.
5. Matsuyama T, Ishii S, Yabuta K, Yamamori S, Morrison NA, Eisman JA 1995 Vitamin D receptors and bone mineral density. Lancet 345:1239-1240.
6. Fleet JC, Harris SS, Wood RJ, Dawson-Hughes B 1995 The BsmI vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 10:985-990.
7. Riggs BL, Nguyen TV, Melton LJ, Morrison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs JM, Eisman JA 1995 The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 10:991-996.
8. Sainz J, Van Tornut JM, Loro ML, Sayre J, Roe TF, Gilsanz V 1997 Vitamin D receptor gene polymorphisms and bone density in prepubertal American girls of Mexican descent. N Engl J Med 337:77-82.
9. Gennari L, Becherini L, Masi L, Mansani R, Gonnelli S, Cepollaro C, Martini S, Montagnani A, Lentini G, Becorpi AM, Brandi ML 1998 Vitamin D and estrogen receptor allelic variants in postmenopausal women: Evidence of multiple gene contribution on bone mineral density. J Clin Endocrinol Metab 83:939-944.
10. Looney JE, Yoon HK, Fischer M, Farley SM, Parley JR, Wergedal JE, Baylink DJ 1995 Lack of a high prevalence of the BB vitamin D receptor genotype in severely osteoporotic women. J Clin Endocrinol Metab 80:2158-2162.
11. Lim SK, Park YS, Park JM, Song YD, Lee EJ, Kim KR, Lee HL, Huh KB 1995 Lack of association between vitamin D receptor genotypes and osteoporosis in Korean. J Clin Endocrinol Metab 80:3677-3681.
12. Garnero P, Borel P, Sornay-Rendu E, Arlot ME, Delmas PD 1996 Vitamin D receptor gene polymorphisms are not related to bone turnover, rates of bone loss and bone mass in post-menopausal women: The OFELY study. J Bone Miner Res 11:827-834.
13. Vandevyver C, Wylin T, Cassiman JJ, Raus J, Geusens P 1997 Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. J Bone Miner Res 12:241-247.
14. Gross C, Eccleshall TR, Malloy PJ, Luz Villa M, Marcus R, Feldman D 1996 The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res 11:1850-1855.
15. Arai H, Miyamoto KI, Taketani Y, Yamamoto H, Iemori Y, Monta K, Tonai T, Nishisho T, Mori S, Takeda E 1997 A vitamin D receptor gene polymorphism in the translation initiation codon: Effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 12:915-921.
16. Harris SS, Eccleshall TR, Gross C, Dawson-Hughes B, Feldman D1997 The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women. J Bone Miner Res 12:1043-1048.
17. Eccleshall TR, Garnero P, Gross C, Delmas PD, Feldman D 1998 Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: The OFELY study. J Bone Miner Res 13:31-35.
18. Ferrari S, Rizzoli R, Manan D, Slosman D, Bonjour JP 1998 Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density: interaction with age, dietary calcium, and 3′-end region polymorphisms. J Bone Miner Res 13:925-930.
19. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N 1994 The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141.
20. McCloskey EV, Spector TD, Eyres KS, Fern ED, O'Rourke N, Vasikaran S, Kanis JA 1993 The assessment of vertebral deformity: A method for use in population studies and clinical trials. Osteoporos Int 3:138-147.
21. Orwoll ES, Oviatt SK, Mann T 1990 The impact of osteophytic and vascular calcification on vertebral mineral density measurements in men. J Clin Endocrinol Metab 70:1202-1207.
22. Masud T, Keen R, Nandra D, Jawed S, Doyle DV, Spector TD 1996 Facet joint osteoarthritis and bone density measurements. In: Papapoulos SE, Lips P, Pols HAP, Johnston CC, Delmas PD (eds.) Osteoporosis 1996. Elsevier Science, Amsterdam, The Netherlands, pp. 167-170.
23. Khoury MJ, Beaty TH, Cohen BH 1993 Foundamental of genetic epidemiology. Oxford University Press NY, New York, U.S.A., pp. 49-54.
24. Morrison NA, Yeoman R, Kelly PJ, Eisman JA 1992 Contribution of trans-acting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphisms and circulating osteocalcin. Proc Natl Acad Sci USA 89:6665-6669.
25. Mundy JR 1994 Boning up on genes. Nature 367:284-287.
26. Garnero P, Arden NK, Griffiths G, Delmas PD, Spector TD 1996 Genetic influence on bone turnover in postmenopausal twins. J Clin Endocrinol Metab 81:140-146.
27. Eisman JA, Kelly P, Morrison NA, Tokita A, Pocock NA, Yeoman R, Ristelli J, Birmingham J, Sambrook PN 1992 Genetic and environmental interaction on bone mass. In: Cohn DV, Gennari C, Tashijan AH (eds.) Calcium regulating hormones. Elsevier Science Publishers, Amsterdam, The Netherlands, pp. 376-383.
28. Krall EA, Parry P, Lichter JB, Dawson-Hughes B 1995 Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake. J Bone Miner Res 10:978-984.
29. Dawson-Hughes B, Harris S, Finneran S 1996 Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab 80:3657-3661.
30. Salamone LM, Glynn NW, Black DM, Ferrell RE, Palermo L, Epstein RS, Kuller LH, Cauley JA 1996 Determinants of premenopausal bone mineral density: The interplay of genetic and lifestyle factors. J Bone Miner Res 11:1557-1565.
31. Ferrari SL, Rizzoli R, Slosman DO, Bonjour JP 1998 Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms? J Bone Miner Res 13:363-370.
32. O'Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ, the European Vertebral Osteoporosis Study Group 1996 The prevalence of vertebral deformity in European men and women: The European vertebral osteoporosis study. J Bone Miner Res 11:1010-1018.
33. Brandi ML, Bianchi ML, Eisman JA, Glorieux F, Adami S, Flore CE, Nuti R, Ortolani S 1994 Genetics of osteoporosis. Calcif Tissue Int 55:161-163.