Animal models of inherited complement deficiency

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 18, Issue 2, 2001, Pages 135-148

  Linton, S ^a  

^a NEVILL HALL HOSPITAL   (United Kingdom)

Author keywords

Animal models; Complement deficiency; Membrane attack complex; Xenotransplantation

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C6;

CLINICAL FEATURE; COMPLEMENT DEFICIENCY; DISEASE ACTIVITY; DISEASE ASSOCIATION; INFECTION RISK; KIDNEY DISEASE; NONHUMAN; PATHOGENESIS; REVIEW;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BACTERIAL INFECTIONS; COMPLEMENT FACTOR H; COMPLEMENT PATHWAY, CLASSICAL; COMPLEMENT SYSTEM PROTEINS; DISEASE MODELS, ANIMAL; GENETIC DISEASES, INBORN; MEMBRANE PROTEINS; PARASITIC DISEASES; RECEPTORS, COMPLEMENT;

EID: 0034931801     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:18:2:135     Document Type: Review

References (84)

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2. Linkage of total deficiency of the second component (C2) of the complement system and of genetic C2-polymorphism to the major histocompatibility complex of the guinea pig
3. Genetically controlled total deficiency of the fourth component of complement in the guinea pig
4. In vitro studies of complement function in sera of C4-deficient guinea pigs
5. Biosynthesis of the MHC-linked complement proteins (C2, C4 and factor B) by mononuclear phagocytes
6. Guinea pigs deficient in C2, C4, C3 or the C3a receptor
7. Influence of genetically inherited complement deficiencies on humoral immune response in guinea pigs
8. Guinea pigs with inherited deficiencies of complement components C2 or C4 have characteristics of immune complex disease
9. IgG and complement-mediated tissue damage in the absence of C2: Evidence of a functionally active C2-bypass pathway in a guinea pig model
10. Differences in susceptibility to infection with Treponema pallidum Nichols between five strains of guinea pigs
11. The time-dependent clearance of virulent Treponema pallidum in susceptible and resistant strains of guinea pigs is significantly different
12. Complement C3 deficiency: Human, animal and experimental models
13. C3-independent glomerulonephritis in guinea pigs: Dependence upon primary humoral response
14. Prolongation of survival of rat heart xenografts in C3 deficient guinea pigs
15. Genetically determined deficiency of the third component of complement in the dog
16. Molecular analysis of the third component of canine complement (C3) and identification of the mutation responsible for hereditary canine C3 deficiency
17. Membranoproliferative glomerulonephritis in dogs with a genetically determined deficiency of the third component of complement
18. The third component of complement protects against Eschericia Coli endotoxin-induced shock and multiple organ failure
19. Complement and neutrophil activation during cardioplumonary bypass: A study in the complement-deficient dog
20. Hereditary C3 hypocomplementemia in the rabbit
21. Distribution, inheritance and properties of an antigen, MuB1, and its relation to haemolytic complement
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23. Mice deficient in C5
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26. Myasthenia gravis: Study of humoral immune mechanisms by passive transfer to mice
27. C5 gene influences the development of murine myasthenia gravis
28. Hereditary absence of complement C5 in adult mice influences Wallerian degeneration, but not retrograde responses, following injury to peripheral nerve
29. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration
30. Cardiac xenotransplantation into complement-5-deficient mice
31. A major role for neutrophils in experimental bullous pemphigoid
32. Deficiency of complement factor C5 reduces early mortality but does not prevent organ damage in an animal model of multiple organ dysfunction syndrome
33. Two chemotactic factors, C5a and MIP-1α, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1α has a protective role
34. Neutrophil mediated remote organ injury after lower torso ischaemia and reperfusion is selectin and complement dependent
35. The role of the complement system in shock and tissue injury induced by tumour necrosis factor and endotoxin
36. Complement component C5 modulates the systemic tumor necrosis factor response in murine endotoxic shock
37. Genetic control of susceptibility to collagen-induced arthritis in T-cell receptor β-chain transgenic mice
38. A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis
39. Lung defenses against Pseudomonas aeruginosa in C5-deficient mice with different genetic backgrounds
40. Hypersusceptibility of A/J mice to tuberculosis is in part due to deficiency of the fifth complement component
41. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: Investigation of the role of host complement in poxvirus pathogenesis
42. Pathogenicity of Saccharomyces cerevisiae in complement factor five-deficient mice
43. Deficiency of the sixth component of complement in rabbits with an inherited complement defect
44. Hereditary C6 deficiency in a strain of PVG/c rats
45. Genetic control of C6 polymorphism and C6 deficiency in rabbits
46. Acute serum sickness in normal and C6 deficient rabbits: Role of membrane attack complex
47. Influence of the terminal complement-complex on reperfusion injury, no-reflow and arrythmias: A comparison between C6-competent and C6-deficient rabbits
48. Attenuation of interleukin-8 expression in C6-deficient rabbits after myocardial ischaemia/reperfusion
49. Complement C6-deficiency protects against diet-induced atherosclerosis in rabbits
50. Role of late complement components in experimental autoimmune thyroiditis
51. Role of complement pathway in accelerated autologous antiglomerular basement membrane nephritis
52. Characterisation of complement C6 deficiency in a PVG/c rat strain
53. Endotoxin-induced lung inflammation is independent of the complement membrane-attack complex
54. Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis
55. Extrahepatic C6 is as effective as hepatic C6 in the generation of renal C5b-9 complexes
56. The contribution of terminal complement components to acute and hyperacute allograft rejection in the rat
57. Complement contributes to the rejection of complete and class I major histocompatibility complex- incompatible cardiac allografts
58. The cellular basis of cardiac allograft rejection: VIII. Mechanisms underlying delayed allograft rejection in PVG C6-deficient rats
59. Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat
60. Use of C6-deficient rats to evaluate the mechanism of hyperacute rejection of discordant cardiac xenografts
61. Natural killer cells, antibody-dependent cellular cytotoxicity and complement synthesis by the xenograft itself play a role in xenograft rejection
62. The role of CD11b/CD18 mediated neutrophil adhesion in complement deficient xenograft recipients
63. Posttransplant nonfunction of canine islets in PVG rats deficient in complement component C6
64. Prolonged discordant xenograft survival by inhibition of the intrinsic coagulation pathway in complement C6-deficient recipients
65. Hyperacute rejection in the guinea pig-to-rat model without formation of the membrane attack complex
66. Mouse-to-rabbit xenotransplantation: A new small animal model of hyperacute rejection mediated by the classical complement pathway
67. Deoxyspergualin delays xenograft rejection in the guinea pig-to-C6-deficient rat heart transplantation model
68. The effect of macrophage depletion on delayed xenograft rejection studies in the guinea pig-to-C6-deficient rat heart transplantation model
69. Cyclosporine induces long-term xenograft survival in the mouse-to-C6-deficient rat heart transplantation model
70. Induction of accommodation in the hamster-to-rat model requires inhibition of the membrane attack complex of complement
71. Complement-and xenoantibody-independent discordant xenograft rejection in a guinea pig to rat model
72. Prolonged survival of guinea pig-to-rat heart xenografts following complement depletion and B-cell-directed immunosuppression by malononitrilamide
73. Renal microvascular injury induced by antibody to glomerular endothelial cells is mediated by C5b-9
74. C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis
75. Complement membrane attack complex (C5b-9) mediates interstitial disease in experimental nephrotic syndrome
76. C6 polymorphism and C6 deficiency in site strains of the mutation-prone Peru-Coppock mice
77. Predominant role for C5b-9 in renal ischaemia/reperfusion injury
78. Genetic deficiency of the α-γ subunit of the eighth complement component in the rabbit
79. Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit
80. Gene responsible for deficient activity of the β subunit of C8, the eighth component of complement, is located on mouse chromosome 4
81. Hereditary porcine membranoproliferative glomerulonephritis type II is caused by Factor H deficiency
82. Characterisation of C3a receptor-proteins on guinea pig platelets and human polymorphonuclear leukocytes
83. Minor role of the C3a receptor in systemic anaphylaxis in the guinea pig
84. The role of C3a and C5a in hyperacute rejection of guinea pig-to-rat cardiac xenografts