IgG and complement-mediated tissue damage in the absence of C2: Evidence of a functionally active C2-bypass pathway in a guinea pig model

Journal of Immunology

Volumn 163, Issue 6, 1999, Pages 3549-3558

  Wagner, Eric ^a   Platt, Jeffrey L ^b   Howell, David N ^a,c   Marsh Jr , Henry C ^d   Frank, Michael M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

^d AVANT Immunotherapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C4; EGTAZIC ACID; FORSSMAN ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; MAGNESIUM DERIVATIVE; RECOMBINANT RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DEPENDENT CYTOTOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SIMULATION; GUINEA PIG; HEMOLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; SERUM; SHEEP ERYTHROCYTE; SHOCK;

ANAPHYLAXIS; ANIMALS; ANTIBODIES, HETEROPHILE; COMPLEMENT ACTIVATION; COMPLEMENT C2; COMPLEMENT C4; COMPLEMENT PATHWAY, ALTERNATIVE; COMPLEMENT PATHWAY, CLASSICAL; GUINEA PIGS; HEMOLYSIS; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; LUNG; MODELS, IMMUNOLOGICAL; PULMONARY EDEMA;

EID: 0033568192     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Morgan, B. P., and M. J. Walport. 1991. Complement deficiency and disease. Immunol. Today 12:301.
2. May, J. E., and M. M. Frank. 1973. A new complement-mediated cytolytic mechanism: the C1-bypass activation pathway. Proc. Natl. Acad. Sci. USA 70:649.
3. Matsushita, M., and H. Okada. 1986. Alternative complement pathway activation by C4b deposited during classical pathway activation. J. Immunol. 136:2994.
4. Steuer, K. L. K., L. B. Sloan, T. J. Oglesby, T. C. Farries, M. W. Nickells, P. Densen, J. B. Harley, and J. P. Atkinson. 1989. Lysis of sensitized sheep erythrocytes in human sera deficient in the second component of complement. J. Immunol. 143:2256.
5. May, J. E., and M. M. Frank. 1973. Hemolysis of sheep erythrocytes in guinea pig serum deficient in the fourth component of complement. I. Antibody and serum requirements. J. Immunol. 111:1661.
6. May, J. E., and M. M. Frank. 1973. Hemolysis of sheep erythrocytes in guinea pig serum deficient in the fourth component of complement. II. Evidence for involvement of C1 and components of the alternate complement pathway. J. Immunol. 111:1668.
7. Farries, T. C., K. L. K. Steuer, and J. P. Atkinson. 1990. The mechanism of activation of the alternative pathway of complement by cell-bound C4b. Mol. Immunol. 27:1155.
8. Deguchi, M., F. D. Gillin, and I. Gigli. 1987. Mechanism of killing of Giardia lamblia trophozoites by complement. J. Clin. Invest. 79:1296.
9. Ballow, M., G. W. Ward, M. E. Gershwin, and N. K. Day. 1975. C1-bypass complement activation pathway in patients with chronic urticaria and angio-oedema. Lancet 2:248.
10. Nolin, L., S. O'Regan, M. Pelletier, G. E. Rivard, J.-G. Mongeau, and P. Robitaille. 1979. Possible C1q bypass loop activation in the haemolytic uraemic syndrome. Clin. Exp. Immunol. 35:107.
11. Traustadóttir, K. H., B. O. Rafnar, K. Steinsson, H. Valdimarsson, and K. Erlendsson. 1998. Participation of factor B in residual immune complex red cell binding activity observed in serum from a C2-deficient systemic lupus erythematosus patient may delay the appearance of clinical symptoms. Arthritis Rheum. 41:427.
12. May, J. E., and M. M. Frank. 1972. Complement-mediated tissue damage: contribution of the classical and alternative pathways in the Forssman reaction. J. Immunol. 108:1517.
13. Gaither, T. A., and M. M. Frank. 1988. Complement. In Clinical Diagnosis and Management by Laboratory Methods. J. B. Henry, ed. Saunders, Philadelphia, p. 830.
14. Pangburn, M. K. 1988. Alternative pathway of complement. Methods Enzymol. 162:639.
15. Weisman, H. F., T. Bartow, M. K. Leppo, H. C. Marsh, Jr., G. R. Carson, M. F. Concino, M. P. Boyle, K. H. Roux, M. L. Weisfeldt, and D. T. Fearon. 1990. Soluble complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 249:146.
16. Scesney, S. M., S. C. Makrides, M. L. Gosselin, P. J. Ford, B. M. Andrews, E. G. Hayman, and H. C. Marsh, Jr. 1996. A soluble deletion mutant of the human complement receptor type 1, which lacks the C4b binding site, is a selective inhibitor of the alternative complement pathway. Eur. J. Immunol. 26:1729.
17. Murohara, T., J.-P. Guo, J. A. Delyani, and A. M. Lefer. 1995. Cardioprotective effects of selective inhibition of the two complement activation pathways in myocardial ischemia and reperfusion injury. Methods Find. Exp. Clin. Pharmacol. 17:499.
18. Bitter-Suermann, D., T. Hoffman, R. Burger, and U. Hadding. 1981. Linkage of total deficiency of the second component (C2) of the complement system and of genetic C2-polymorphism to the major histocompatibility complex of the guinea pig. J. Immunol. 127:608.
19. Ellman, L., I. Green, and M. M. Frank. 1970. Genetically controlled total deficiency of the fourth component of complement in the guinea pig. Science 170:74.
20. Gaither, T. A., D. W. Ailing, and M. M. Frank. 1974. A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement. J. Immunol. 113:574.
21. Ngan, B.-Y., E. W. Gelfand, and J. O. Minta. 1977. A simple one-step hemolytic assay for C2 with C2-deficient human serum. J. Immunol. 118:736.
22. McKinney, M. M., and A. Parkinson. 1987. A simple, non-chromatographic procedure to purify immunoglobulins from serum and ascites fluid. J. Immunol. Methods 96:271.
23. Mayer, M. M. 1961. Complement and complement fixation. In Experimental Immunochemistry. E. A. Kabat and M. M. Mayer, eds. Thomas, Springfield, IL, p. 133.
24. Bauman, N., and W. J. Elliott. 1972. The relative efficacies of 7S and 19S Forssman antibody in producing lesions in the guinea pig. Proc. Soc. Biol. Med. 139: 670.
25. Frank, M. M., R. R. Dourmashkin, and J. H. Humphrey. 1970. Observations on the mechanism of immune hemolysis: importance of immunoglobulin class and source of complement on the extent of damage. J. Immunol. 104:1502.
26. Moore, F. D., Jr., D. T. Fearon, and K. F. Austen. 1981. IgG on mouse erythrocytes augments activation of the human alternative complement pathway by enhancing deposition of C3b. J. Immunol. 126:1805.
27. Reilly, B. D., S. C. Makrides, P. J. Ford, H. C. Marsh, and C. Mold. 1994. Quantitative analysis of C4b dimer binding to distinct sites on the C3b/C4b receptor (CR1). J. Biol. Chem. 269:7696.
28. Krych, M., L. Clemenza, D. Howdeshell, R. Hauhart, D. Hourcade, and J. P. Atkinson. 1994. Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor, CD35) by substitution mutagenesis. J. Biol. Chem. 269:13273.
29. Frank, M. M., J. E. May, T. A. Gaither, and L. Ellman. 1971. In vitro studies of complement function in sera of C4-deficient guinea pigs. J. Exp. Med. 134:176.
30. Birmingham, D. J. 1995. Erythrocyte complement receptors. Crit. Rev. Immunol. 15:133.
31. Turner, M. W. 1998. Mannose-binding lectin (MBL) in health and disease. Immunobiology 199:327.
32. Malhotra, R., M. R. Wormald, P. M. Rudd, P. B. Fisher, R. A. Dwek, and R. B. Sim. 1995. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat. Med. 1:237.
33. Suankratay, C., X.-H. Zhang, Y. Zhang, T. F. Lint, and H. Gewurz. 1998. Requirement for the alternative pathway as well as C4 and C2 in complement-dependent hemolysis via the lectin pathway. J. Immunol. 160:3006.
34. Farries, T. C., K. L. K. Steuer, and J. P. Atkinson. 1990. Evolutionary implications of a new bypass activation pathway of the complement system. Immunol. Today 11:78.
35. Ochs, H. D., R. J. Wedgwood, M. M. Frank, S. R. Heller, and S. W. Hosea. 1983. The role of complement in the induction of antibody responses. Clin. Exp. Immunol. 53:208.
36. Böttger, E. C., T. Hoffmann, U. Hadding, and D. Bitter-Suermann. 1985. Influence of genetically inherited complement deficiencies on humoral immune response in guinea pigs. J. Immunol. 135:4100.
37. Ochs, H. D., R. J. Wedgwood, S. R. Heller, and P. G. Beatty. 1986. Complement, membrane glycoproteins, and complement receptors: their role in regulation of the immune response. Clin. Immunol. Immunopathol. 40:94.