The role of CD11b/CD18 mediated neutrophil adhesion in complement deficient xenograft recipients

Clinical Transplantation

Volumn 11, Issue 5 II, 1997, Pages 516-521

  Jakobs, Frank M ^a   Davis, Elizabeth A ^a   Qian, Zhiping ^a   Liu, David Y ^b   Baldwin III, William M ^a   Sanfilippo, Fred ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCIOS INC   (United States)

Author keywords

C6 deficiency; CD18; Hyperacute rejection; Leumedin; Nactin; Neutrophil adhesion; Xenotransplantation

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; COMPLEMENT; COMPLEMENT MEMBRANE ATTACK COMPLEX;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; COMPLEMENT ACTIVATION; COMPLEMENT DEFICIENCY; CONTROLLED STUDY; ENDOTHELIUM INJURY; GRAFT REJECTION; GUINEA PIG; HEART TRANSPLANTATION; HISTOLOGY; INFLAMMATION; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; XENOGRAFT;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGENS, CD11; ANTIGENS, CD18; BLOOD COAGULATION FACTORS; CELL ADHESION; COMPLEMENT ACTIVATION; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; ENDOTHELIUM, VASCULAR; GRAFT REJECTION; GRAFT SURVIVAL; GUINEA PIGS; HEART TRANSPLANTATION; HEMORRHAGE; IMMUNOSUPPRESSIVE AGENTS; LEUCINE; MALE; NEUTROPHILS; RATS; RATS, INBRED STRAINS; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HETEROTOPIC;

EID: 0030731342     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. BRAUER RB, BALDWIN WM III, DAHA MR, PRUITT SK, SANFILIPPO F. Use of C6-deficient rats to evaluate the mechanism of hyperacute rejection of discordant cardiac xenografts. J Immunol 1993: 151: 7240-8.
2. DAVIS EA, LAM TT, QIAN ZP, IBRAHIM S, BALDWIN WM III, SANFILIPPO F. Inhibition of neutrophil adhesion and the membrane attack complex of complement synergistically prolongs cardiac xenograft survival. J Heart Lung Transpl 1995: 14: 973-80.
3. ONO K, LINDSEY ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969. 57: 225-9.
4. MCCURRY KR, KOOYMAN DL, ALVARADO CG, et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1995: 1: 423.
5. GERWURZ H, CLARK DS, COOPER MD, VARCO RL, GOOD RA. Effect of cobra venom-induced inhibition of complement activity on allograft and xenograft rejection reactions. Transplantation 1967: 5: 1296-1303.
6. PRUITT SK, BALDWIN WM III, MARSH HC JR, LIN SS, YEH CG, BOLLINGER RR. The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. Transplantation 1991: 52: 868-73.
7. BRAUER RB, BALDWIN WM III, WANG D, PRUITT SK, KLEIN AS, SANFILIPPO F. Functional activity of anti-C6 antibodies elicited in C6-deficient rats reconstituted by liver allografts. Ability to inhibit hyperacute rejection of discordant cardiac xenografts. Transplantation 1996: 61: 588.
8. LEVENTHAL JR, SAKIYALAK P, WITSON J, et al. The synergistic effect of combined antibody and complement depletion on discordant xenograft survival in nonhuman primates. Transplantation 1994: 57: 974.
9. BLAKELY ML, VAN DER WERF WJ, BERNDT MC, DALMASSO AP, BACH FH, HANCOCK WW. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 1994: 58: 1059.
10. BACH FH, ROBSON SC, FERRAN C, et al. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev 1994: 141: 5.
11. DAVIS EA, PRUITT SK, GREENE PS, et al. Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts. Transplantation 1996: 62: 1018-23.
12. ZEHR KJ, HERSKOWITZ A, LEE PC, POSTON RS, GILLINOV AM, BAUMGARTNER WA. Neutrophil adhesion inhibition prolongs survival of cardiac allografts with hyperacute rejection. J Heart Lung Transplant 1993: 12: 837-45.
13. ZEHR KJ, HERSKOWITZ A, LEE PC, KUMAR P, GILLINOV AM, BAUMGARTNER WA. Neutrophil adhesion and complement inhibition prolongs survival of cardiac xenografts in discordant species. Transplantation 1994: 57: 900-6.
14. KISHIMOTO TK, HOLLANDER N, ROBERTS TM, ANDERSON DC, SPRINGER TA. Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte deficiency. Cell 1987: 50: 193-202.
15. WEISS SJ. Tissue destruction by neutrophils. N Engl J Med 320: 365-76.
16. HARLAN JM, WINN RK, VEDDER NB, DOERSCHUK CM, RICE CL. In vivo models of leukocyte adherence to endothelium. In: HARLAN JM, LIU DY, eds. Adhesion: Its role in inflammatory disease, p. 130, New York: WH Freeman and Co., 1992.
17. BRAUER RB, BALDWIN WM III, PRUITT SK, SANFILIPPO F. Survival of guinea pig cardiac xenografts in Co-deficient PVG rats treated with monoclonal antibody to CD18. Transplant Proc 1994: 26: 1251.
18. 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1. J Pharmacol Exp Ther 1996: 276(1): 5-12.
19. ALTIERI DC, BADER R, MANNUCCI PM, EDGINGTON TS. Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen. J Cell Biol 1988: 107: 1893-1900.
20. ALTIERI DC, EDGINGTON TS. The saturable high affinity association of Factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor. J Biol Chem 1988: 263: 7007-15.