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of outstanding interest. Brain factor BF-1 is the only gene to date that has its expression almost entirely restricted to cells that contribute to the telencephalon. The authors demonstrate that it is also essential for normal telencephalic development.
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of special interest. Like Lim1, Otx2 is required for head development. It is interesting that along with the Empty Spiracles family of genes, Orthodenticle genes have Drosophila homologs that are also restricted to the head, suggesting that at least some of the genetic components that lead to head formation are widely conserved.
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A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
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of special interest. Although the defects in the ventral telencephalon in the distal-less Dlx-2 knock-out are comparatively minor, at least four other related distal-less genes are expressed within the ventral telencephalon. It is likely that further targetting of genes within this family will reveal that they play a major role in ventral telencephalic patterning.
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Mutation of the Emx-1 homeobox gene disrupts the corpus callosum
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Qiu M, Anderson S, Chen S, Meneses JJ, Hevner R, Kuwana E, Pedersen RA, Rubenstein JL. Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. of special interest Dev Biol. 178:1996;174-178 The first of three papers (see also [19,20]) that examines the phenotype resulting from ablation of the Emx-1 gene. The authors make the interesting observation that the major commissural projection between the cortical hemispheres is disrupted when this gene is mutated.
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of special interest. The effect fo deleting each of the two known Emx genes individually is investigated. These genes are expressed in a nested pattern within the dorsal telencephalon, and, correspondingly, defects appear to reflect regions where their expression does not overlap. As each is probably capable of substituting functionally for the other, it will be interesting to see the effects of the double knock-out when it is generated.
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Yoshida M, Suda Y, Matsuo I, Miyamoto N, Takeda N, Kuratani S, Aizawa S. Emx1 and Emx2 functions in development of dorsal telencephalon. of special interest Development. 124:1997;101-111 The effect fo deleting each of the two known Emx genes individually is investigated. These genes are expressed in a nested pattern within the dorsal telencephalon, and, correspondingly, defects appear to reflect regions where their expression does not overlap. As each is probably capable of substituting functionally for the other, it will be interesting to see the effects of the double knock-out when it is generated.
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of special interest. As in an earlier paper [18], the effect of deleting Emx-2 is restricted to the area where Emx-1 expression is absent (i.e. the hippocampus). Absence of this gene results in a very specific deletion of part of the hippocampus, a telencephalic structure in which Emx-2, b ut not Emx-1, is expressed.
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