Genetic manipulation of the renin-angiotensin system

Current Opinion in Nephrology and Hypertension

Volumn 10, Issue 4, 2001, Pages 483-491

  Doan, Thanh N ^a   Gletsu, Nana ^a   Cole, Justin ^a   Bernstein, Kenneth E ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSINOGEN; DNA; RENIN;

BLOOD PRESSURE REGULATION; CONCEPTION; EMBRYO CELL; GENETIC ENGINEERING; GENETIC RECOMBINATION; HEMATOCRIT; KIDNEY DEVELOPMENT; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; STEM CELL;

ANEMIA; ANIMALS; BLOOD PRESSURE; FEMALE; FERTILITY; HUMANS; KIDNEY; KIDNEY CONCENTRATING ABILITY; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RENIN-ANGIOTENSIN SYSTEM; SEX CHARACTERISTICS;

EID: 0034924853     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200107000-00002     Document Type: Review

References (48)

1. Understanding hypertension through genetic manipulation in mice
2. Targeted gene replacement
3. Targeted interruption of the renin-angiotensin system
4. Genetic control of blood pressure and the angiotensinogen locus
5. A mouse view of hypertension
6. Gene targeting approaches to analyzing hypertension
7. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility
8. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice
9. Targeting genes for self-excision in the germline
10. Normotensive blood pressure in mice with a disrupted renin Ren-1d gene
11. Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology
12. Mouse angiotensin receptor genes Agtr1a and Agtr1b map to chromosome 13 and 3
13. Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)
14. Angiotensinogen-deficient mice with hypotension
15. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth regulation
16. Rescue of angiotensinogen-knockout mice
17. Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice
18. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
19. Mouse angiotensin I-converting enzyme is a protein composed of two homologous domains
20. Male-female differences in fertility and blood pressure in ACE-deficient mice
21. Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene
22. Transgenic mice demonstrate a testis-specific promoter for angiotensin-converting enzyme
23. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
24. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
25. A noninvasive computerized tail-cuff system for measuring blood pressure in mice
26. Regulation of blood pressure by the type 1A angiotensin II receptor gene
27. Targeting deletion of angiotensin type 1B receptor gene in the mouse
28. 2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II
29. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes
30. 1B receptors in blood pressure regulation
31. 2) angiotensin receptor
32. 2 null mutant mice
33. Nephrogenesis and renovascular development in angiotensinogen-deficient mice
34. Pathologic characterization of hypotensive C57BL/6J-agt: Angiotensin-deficient C57BL/6J mice
35. Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme
36. Renin-angiotensin system in neonatal rats: Induction of renal abnormality in response to ACE inhibition or angiotensin II antagonism
37. An intact renin-angiotensin system is a prerequisite for normal renal development
38. Angiotensin II regulates nephrogenesis and renal vascular development
39. Angiotensin induces the urinary peristaltic machinery during the perinatal period
40. 1A receptors for angiotensin II
41. 1A receptor null mice
42. Abnormal water metabolism in mice lacking the type 1A receptor for AngII
43. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice
44. Concentration of the angiotensin-converting enzyme in tissues of rat
45. Sperm-specific expression of angiotensin-converting enzyme (ACE) is mediated by a 91-base-pair promoter containing a CRE-like element
46. Expression of testis angiotensin-converting enzyme is mediated by a cyclic AMP responsive element
47. Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme
48. Angiotensin-converting enzyme and male fertility