Expression of testis angiotensin-converting enzyme is mediated by a cyclic AMP responsive element

Laboratory Investigation

Volumn 77, Issue 5, 1997, Pages 483-488

  Esther Jr , Charles R ^a   Semeniuk, Daniel ^a   Marino, Elaine M ^a   Zhou, Yudong ^a   Overbeek, Paul A ^b   Bernstein, Kenneth E ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DIPEPTIDYL CARBOXYPEPTIDASE;

ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; MALE; MALE FERTILITY; MOUSE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; SITE DIRECTED MUTAGENESIS; SPERMATOZOON MATURATION; TISSUE INDUCTION; TISSUE SPECIFICITY;

ANIMALS; BETA-GALACTOSIDASE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENES, REPORTER; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; ORGAN SPECIFICITY; PEPTIDYL-DIPEPTIDASE A; PROMOTER REGIONS (GENETICS); TESTIS;

EID: 0343035567     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bernstein KE and Berk BC (1993). The biology of angiotensin II receptors. Am J Kidney Dis 22:745-754.
2. Blendy JA, Kaestner KH, Weinbauer GF, Nieschlag E, and Schutz G (1996). Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380:162-165.
3. Bradford NA (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254.
4. Bucher P (1990). Weight matrix descriptions of four eukaryotic RNA polymerase II elements derived from 502 unrelated promoter sequences. J Mol Biol 212:563-578.
5. Corvol P, Williams TA, and Soubrier F (1995). Peptidyl dipeptidase A: Angiotensin I-converting enzyme. Methods Enzymol 248:283-305.
6. Cushman DW and Cheung HS (1971). Concentrations of angiotensin-converting enzyme in tissues of the rat. Biochim Biophys Acta 250:261-265.
7. de Groot RP, Delmas V, and Sassone-Corsi P (1993). DNA bending by transcription factors CREM and CREB. Oncogene 9:463-488.
8. Delmas V and Sassone-Corsi P (1994). The key role of CREM in the cAMP signaling pathway in the testis. Mol Cell Endocrinol 100:121-124.
9. Ehlers MR, Fox EA, Strydom DJ, and Riordan JF (1989). Molecular cloning of human testicular angiotensin-converting enzyme: The testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme. Proc Natl Acad Sci USA 86:7741-7745.
10. El-Dorry HA, Bull HG, Iwata K, Thornberry NA, Cordes EH, and Soffer RL (1982). Molecular and catalytic properties of rabbit testicular dipeptidyl carboxypeptidase. J Biol Chem 257:14128-14133.
11. Esther CR Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE (1996). Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology and reduced male fertility. Lab Invest 74:953-965.
12. Esther CR Jr, Marino EM, Howard TE, Corvol P, Capecchi MR, and Bernstein KE (1997). The critical role of tissue angiotensin converting enzyme (ACE) as revealed by gene targeting in mice. J Clin Invest 99:2375-2385.
13. Ha H, van Wijnen AJ, and Hecht NB (1997). Tissue-specific protein-DNA interactions of the mouse protamine 2 gene promoter. J Cell Biochem 64:95-105.
14. Howard TE, Balogh R, Overbeek P, and Bernstein KE (1992). Sperm specific expression of angiotensin-converting enzyme (ACE) is mediated by a 91 base pair promoter encoding a CRE-like element. Mol Cell Biol 13:18-27.
15. Howard TE, Shai S-Y, Langford KG, Martin BM, and Bernstein KE (1990). Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene. Mol Cell Biol 10:4294-4302.
16. Iannello RC, Young J, Sumarsono S, Tymms MJ, Dahl HH, Gould J, Hedger M, and Kola I (1997). Regulation of Pdha-2 expression is mediated by proximal promoter sequences and CpG methylation. Mol Cell Biol 17:612-619.
17. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, and Smithies O (1995). Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 92:2735-2739.
18. Krege JH, John SWM, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, and Smithies O (1995). Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 375:146-148.
19. Kumar RS, Kusari J, Roy SN, Soffer RL, and Sen GC (1989). Structure of testicular angiotensin converting enzyme: A segmental mosaic isozyme. J Biol Chem 264:16754-16758.
20. Lamas M, Monaco L, Zazopoulos E, Lalli E, Tamai K, Penna L, Mazzucchelli C, Nantel F, Foulkes NS, and Sassone-Corsi P (1996). CREM: A master-switch in the transcriptional response to cAMP. Philos Trans R Soc Lond Biol Sci 351:561-567.
21. Langford KG, Shai S-Y, Howard TE, Kovac MJ, Overbeek PA, and Bernstein KE (1991). Transgenic mice demonstrate a testis specific promoter for angiotensin converting enzyme (ACE). J Biol Chem 266:15559-15562.
22. Langford KG, Zhou Y, Russell LD, Wilcox JN, and Bernstein KE (1993). Regulated expression of testis angiotensin-converting enzyme during spermatogenesis. Biol Reprod 48:1210-1218.
23. Lattion A-L, Soubrier F, Allegrini J, Hubert C, Corvol P, and Alhenc-Gelas F (1989). The testicular transcript of the angiotensin I-converting enzyme encodes for the ancestral, non-duplicated form of the enzyme. FEBS Lett 252:99-104.
24. Murti JR and Schimenti JC (1991). Microwave-accelerated fixation and lac-Z activity staining of testicular cells in transgenic mice. Anal Biochem 198:92-96.
25. Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksen K, Dierich A, Parvinen M, and Sassone-Corsi P (1996). Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 380:159-162.
26. Roesler W, Vandenbark G, and Hanson R (1988). Cyclic AMP and the induction of eukaryotic gene transcription. J Biol Chem 263:9063-9066.
27. Searle PF, Davison BL, Stuart GW, Wildie TM, Norstedt G, and Palmiter RD (1984). Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol 4:1221-1230.
28. Strittmatter SM and Snyder SH (1984). Angiotensin-converting enzyme in the male rat reproductive system: Autoradiographic visualization of [3H] captopril. Endocrinology 115:2332-2341.
29. Sun Z, Sassone-Corsi P, and Means AR (1995). Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. Mol Cell Biol 15:561-571.
30. Zhou Y, Delafontaine P, Martin BM, and Bernstein KE (1995). Identification of two positive transcriptional elements within the 91-base pair promoter for mouse testis angiotensin converting enzyme (testis ACE). Dev Genet 16:201-209.
31. Zhou Y, Overbeek PA, and Bernstein KE. (1996a). Tissue specific expression of testis angiotensin converting enzyme is not determined by the -32 nonconsensus TATA motif. BBRC 223:48-53.
32. Zhou Y, Sun Z, Means AR, Sassone-Corsi P, and Bernstein KE. (1996b). CREMτ is a positive regulator of testis ACE transcription. Proc Natl Acad Sci USA 93:12262-12266.