Insights into apolipoprotein B biology from transgenic and gene-targeted mice

Journal of Nutrition

Volumn 129, Issue 2 SUPPL., 1999, Pages

  Véniant, Murielle M ^a   Kim, Edward ^a   McCormick, Sally ^a   Borén, Jan ^a   Nielsen, Lars Bo ^a   Raabe, Martin ^a   Young, Stephen G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Heart; Hypobetalipoproteinemia; Metabolism; Protein structure function; Yolk sac endoderm

Indexed keywords

APOLIPOPROTEIN B;

ATHEROGENESIS; CONFERENCE PAPER; EMBRYO DEVELOPMENT; GENE TARGETING; HEART DEVELOPMENT; HEART MUSCLE CELL; HUMAN; LIPOPROTEIN METABOLISM; NONHUMAN; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE;

MAMMALIA; MUS MUSCULUS;

EID: 0345003924     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.2.451s     Document Type: Conference Paper

References (37)

1. Baserga, S. J. & Benz, E. J., Jr. (1988) Nonsense mutations in the human β-globin gene affect mRNA metabolism. Proc. Natl. Acad. Sci. U.S.A. 85: 2056-2060.
2. Baserga, S. J. & Benz, E. J., Jr. (1992) β-Globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability. Proc. Natl. Acad. Sci. U.S.A. 89: 2935-2939.
3. Borén, J., Véniant, M. M. & Young, S. G. (1998) ApoB100-containing lipoproteins are secreted by the heart. J. Clin. Investig. 101: 1197-1202.
4. Callow, M. J. & Rubin, E. M. (1995) Site-specific mutagenesis demonstrates that cysteine 4326 of apolipoprotein B is required for covalent linkage with apolipoprotein(a) in vivo. J. Biol. Chem. 270: 23914-23917.
5. Callow, M. J., Stoltzfus, L. J., Lawn, R. M. & Rubin, E. M. (1994) Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 91: 2130-2134.
6. Davidson, N. O. (1994) RNA editing of the apolipoprotein B gene. A mechanism to regulate the atherogenic potential of intestinal lipoproteins? Trends Cardiovasc. Med. 4: 231-235.
7. Farese, R. V., Jr., Cases, S., Ruland, S. L., Kayden, H. J., Wong, J. S., Young, S. G. & Hamilton, R. L. (1996a) A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice. J. Lipid Res. 37: 347-360.
8. Farese, R. V., Jr., Garg, A., Pierotti, V. R., Vega, G. L., & Young, S. G. (1992) A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia. J. Lipid Res. 33: 569-577.
9. Farese, R. V., Jr., Ruland, S. L., Flynn, L. M., Stokowski, R. P. & Young, S. G. (1995) Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc. Natl. Acad. Sci. U.S.A. 92: 1774-1778.
10. Farese, R. V., Jr., Véniant, M. M., Cham, C. M., Flynn, L. M., Pierotti, V., Loring, J. F., Traber, M., Ruland, S., Stokowski, R. S., Huszar, D. & Young, S. G. (1996b) Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc. Natl. Acad. Sci. U.S.A. 93: 6393-6398.
11. Goldberg, I. J. (1996) Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 37: 693-707.
12. Gordon, D. A., Jamil, H., Gregg, R. E., Olofsson, S.-O. & Borén, J. (1996) Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J. Biol. Chem. 271: 33047-33053.
13. Gordon, D. A., Jamil, H., Sharp, D., Mullaney, D., Yao, Z., Gregg, R. E. & Wetterau, J. (1994) Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc. Natl. Acad. Sci. U.S.A. 91: 7628-7632.
14. Greeve, J., Altkemper, I., Dieterich, J.-H., Greten, H. & Windler, E. (1993) Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins. J. Lipid Res. 34: 1367-1383.
15. Havel, R. J. & Kane, J. P. (1995) Introduction: structure and metabolism of plasma lipoproteins. In: The Metabolic and Molecular Bases of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D., eds.), pp. 1841-1851. McGraw-Hill, New York, NY.
16. Homanics, G. E., Smith, T. J., Zhang, S. H., Lee, D., Young, S. G. & Maeda, N. (1993) Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc. Natl. Acad. Sci. U.S.A. 90: 2389-2393.
17. Huang, L.-S., Voyiaziakis, E., Markenson, D. F., Sokol, K. A., Hayek, T. & Breslow, J. L. (1995) Apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. J. Clin. Investig. 96:2152-2161.
18. Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E. & Herz, J. (1993) Hypercholesterolemia in low density lipoprotein receptor knock-out mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Investig. 92: 883-893.
19. Kane, J. P. & Havel, R. J. (1989) Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. In: The Metabolic Basis of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D., eds.) pp. 1139-1164. McGraw-Hill, New York, NY.
20. Kessler, O. & Chasin, L. A. (1996) Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA. Mol. Cell. Biol. 16: 4426-4435.
21. Kim, E., Cham, C. M., Véniant, M. M., Ambroziak, P. & Young, S. G. (1998) Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene. J. Clin. Investig. 101: 1468-1477.
22. Li, X., Catalina, F., Grundy, S. M. & Patel, S. (1996) Method to measure apolipoprotein B-48 and B-100 secretion rates in an individual mouse: evidence for a very rapid turnover of VLDL and preferential removal of B-48-relative to B-100-containing lipoproteins. J. Lipid Res. 37: 210-220.
23. Linton, M. F., Farese, R. V., Jr., Chiesa, G., Grass, D. S., Chin, P., Hammer, R. E., Hobbs, H. H. & Young, S. G. (1993a) Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). J. Clin. Investig. 92: 3029-3037.
24. Linton, M. F., Farese, R. V., Jr. & Young, S. G. (1993b) Familial hypobetalipoproteinemia. J. Lipid Res. 34: 521-541.
25. Maquat, L. E. (1995) When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA 1: 453-465.
26. McCormick, S.P.A., Linton, M. F., Hobbs, H. H., Taylor, S., Curtiss, L. K. & Young, S. G. (1994) Expression of human apolipoprotein B90 in transgenic mice. Demonstration that apolipoprotein B90 lacks the structural requirements to form lipoprotein(a). J. Biol. Chem. 269: 24284-24289.
27. McCormick, S.P.A., Ng, J. K., Cham, C. M., Taylor, S., Marcovina, S. M., Segrest, J. P., Hammer, R. E. & Young, S. G. (1997) Transgenic mice expressing human apoB95 and apoB97. Evidence that sequences within the carboxylterminal portion of human apoB100 are important for the assembly of lipoprotein(a). J. Biol. Chem. 272: 23616-23622.
28. McCormick, S.P.A., Ng, J. K., Taylor, S., Flynn, L. M., Hammer, R. E. & Young, S. G. (1995) Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a). Proc. Natl. Acad. Sci. U.S.A. 92: 10147-10151.
29. McCormick, S.P.A., Peterson, K. R., Hammer, R. E., Clegg, C. H. & Young, S. G. (1996) Generation of transgenic mice from yeast artificial chromosome DNA that has been modified by gene targeting. Trends Cardiovasc. Med. 6: 16-24.
30. Nielsen, L. B., Kahn, D., Duell, T., Weier, H.-U. G., Taylor, S. & Young, S. G. (1998a) Apolipoprotein β gene expression in a series of apoB transgenic mice generated with recA-assisted restriction endonuclease cleavage-modified bacterial artificial chromosomes: an intestine-specific enhancer element is located between 54 and 62 kilobases 5′ to the structural gene. J. Biol. Chem. 273: 21800-21807.
31. Nielsen, L. B., McCormick, S.P.A., Pierotti, V., Tam, C., Gunn, M. D., Shizuya, H. & Young, S. G. (1997) Human apolipoprotein B transgenic mice generated with 207-and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5′-element confers appropriate transgene expression in the intestine. J. Biol. Chem. 272: 29752-29758.
32. Nielsen, L. B., Véniant, M., Hamilton, R. L., Borén, J., Wong, J. S., Tam, C., Flynn, L, Gunn, M. D., Sanan, D., Goldberg, I. & Young, S.G. (1998b) The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: indications that the heart has capacity to synthesize and secrete lipoproteins. Circulation 98: 13-16.
33. Parhofer, K. G., Daugherty, A., Kinoshita, M. & Schonfeld, G. (1990) . Enhanced clearance from plasma of low density lipoproteins containing a truncated apolipoprotein, apoB-89. J. Lipid Res. 31: 2001-2007.
34. Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M. & Maeda, N. (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 89: 4471-4475.
35. Purcell-Huynh, D. A., Farese, R. V., Jr., Johnson, D. F., Flynn, L. M., Pierotti, V., Newland, D. L., Linton, M. F., Sanan, D. A. & Young, S. G. (1995) Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. J. Clin. Investig. 95, 2246-2257.
36. Wetterau, J. R. & Zilversmit, D. B. (1986) Localization of intracellular triacylglycerol and cholesteryl ester transfer activity in rat tissues. Biochim. Biophys. Acta 875: 610-617.
37. Young, S. G. (1990) Recent progress in understanding apolipoprotein B. Circulation 82: 1574-1594.