Regulation of gelatinase-A (MMP-2) production by ovine intervertebral disc nucleus pulposus cells grown in alginate bead culture by transforming growth factor-β1 and insulin like growth factor-I

Cell Biology International

Volumn 25, Issue 7, 2001, Pages 679-689

  Pattison, Scott T ^a   Melrose, James ^a   Ghosh, Peter ^a   Taylor, Thomas K F ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Alginate bead cultures; Gelatinase A; Intervertebral disc; Matrix metalloproteinases; MMP 2; MT1 MMP; Nucleus pulposus; TIMP 2

Indexed keywords

CONCANAVALIN A; GELATINASE A; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL INTERACTION; CELL MIGRATION; CELL REGENERATION; CELL SURFACE; CONNECTIVE TISSUE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FIBROBLAST; HEALING; IN VITRO STUDY; INTERVERTEBRAL DISK; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DETERMINATION; SHEEP; ZYMOGRAPHY;

OVIS;

EID: 0034917290     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1006/cbir.2000.0718     Document Type: Article

References (60)

1. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3
2. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumour angiogenesis
3. IGF-I: A mitogen also involved in differentiation processes in mammalian cells Int.
4. Insulin-like growth factor (IGF) binding proteins and insulin-like growth factor secretion by cultured chondrocyte cells: Identification, characterization and ontogeny during cell differentiation
5. Proteolytic remodelling of extracellular matrix
6. Induction of proliferation or hypertrophy of chondrocytes in serum-free culture: The role of insulin-like growth factor-I, insulin or thyroxine
7. Re-expression of cartilage specific genes by de-differentiated human articular chondrocytes cultured in alginate beads
8. Spine update. Ageing and degeneration of the human intervertebral disc
9. The TIMP-2 membrane type I metalloproteinase "receptor" regulates the concentration and efficient activation of pro-gelatinase A
10. Neovascularization induced by annulus and its inhibition by cartilage endplate
11. Identification of heterogeneous cell populations in normal human intervertebral discs
12. Metabolism of the extracellular matrix formed by intervertebral disc cells cultured in alginate
13. Transforming growth factor-beta (TGF-β)
14. Matrix metalloproteinases in the human intervertebral disc: Role in disc degeneration and scoliosis
15. Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor
16. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylene blue
17. Transforming growth factor b1 inhibits cytokine-mediated induction of human metalloelastase in macrophages
18. Nerve in-growth into the diseased intervertebral disc in chronic back pain
19. Actions of insulin-like growth factors
20. Matrix metalloproteinases: The clue to intervertebral disc degeneration
21. Culture and differentiation of chondrocytes entrapped in alginate gels
22. Human intervertebral disc cells from the annulus: Three dimensional culture in agarose or alginate and responsiveness to TGF-β1
23. Growth factor responsiveness of human articular chondrocytes: Distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts
24. Culture and growth characteristics of chondrocytes encapsulated in alginate beads
25. The Australian and New Zealand experiences with arm-pain and back ache in the work place
26. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads
27. Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads
28. Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface
29. Immunohistochemical study of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in human intervertebral discs
30. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2
31. Fluorometric assay of DNA in cartilage explants using Hoechst 33258
32. A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases
33. Dedifferentiated chondrocytes cultured in alginate beads: Restoration of the differentiated phenotype and of the metabolic responses to interleukin-1β
34. Identification of human intervertebral disc stromelysin and its involvement in matrix degradation
35. Initial characterisation of the metabolism of intervertebral disc cells encapsulated in microspheres
36. Metalloproteinases and their inhibitors in matrix remodeling
37. The involvement of matrix metalloproteinases and inflammation in lumbar disc degeneration
38. Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage
39. Topographical variation in the catabolism of aggrecan in an ovine annular lesion model of experimental disc degeneration
40. Differential expression of proteoglycan epitopes by ovine intervertebral disc cells grown in alginate bead culture
41. Differential expression of proteoglycan epitopes and growth characteristics of ovine intervertebral disc cells grown in alginate bead culture
42. Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes
43. The regulation of neovascularization by matrix metalloproteinases and their inhibitors
44. Matrix metalloproteinases and their inhibitors
45. Mechanisms of tissue repair: From wound healing to fibrosis
46. Matrix metalloproteinases
47. Activation mechanisms of matrix metalloproteinases
48. Transforming growth factor βs and wound healing
49. Autocrine/paracrine mechanism of insulin-like growth factor-I secretion, and the effect of insulin-like growth factor-I on proteoglycan synthesis in bovine intervertebral discs
50. Concanavalin A produces a matrix-degradative phenotype in human fibroblasts
51. Nucleus pulposus regeneration after chemonucleolysis with chymopapain?
52. Manipulating Angiogenesis
53. Tumor-associated angiogenesis: Mechanisms, clinical implications, and therapeutic strategies
54. Detection of viable and non-viable cells in connective tissue explants using the fixable fluoroprobes 5-chloromethylfluorescein diacetate and ethidium homodimer-1
55. Extracellular collagen modulates the regulation of chondrocytes by transforming growth factor-β1
56. Measurement of protein using bicinchononic acid
57. Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2
58. Stimulation of mature canine intervertebral disc by growth factors
59. Development and degeneration of the intervertebral disc
60. The family of matrix metalloproteinases