Establishment of okadaic acid resistant cell clones using a cDNA expression library

Cell Death and Differentiation

Volumn 8, Issue 7, 2001, Pages 754-766

  Sandal, T ^a   Ahlgren, R ^a   Lillehaug, J ^b   Doskeland S O ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b Department of Molecular Biology   (Norway)

Author keywords

Apoptosis; Cloning; Multidrug resistance; Okadaic acid; Protein phosphorylation; Retrovirus

Indexed keywords

CALYCULIN A; CANTHARIDIN; CASPASE 3; CASPASE 9; COMPLEMENTARY DNA; CYTOCHROME C; OKADAIC ACID; PHOSPHOPROTEIN; STAUROSPORINE; VIRUS VECTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CLONE; CELL DEATH; CELL SELECTION; CONTROLLED STUDY; CROSS RESISTANCE; DNA LIBRARY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RETROVIRUS;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CASPASES; CELL SIZE; CLONE CELLS; CLONING, MOLECULAR; CYTOCHROME C GROUP; DRUG RESISTANCE; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; FIBROBLASTS; GENE LIBRARY; HUMANS; JURKAT CELLS; MICE; MOLECULAR SEQUENCE DATA; OKADAIC ACID; PHENOTYPE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; STAUROSPORINE; TRANSFECTION;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0034915920     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400873     Document Type: Article

References (94)

1. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
2. An evolutionary perspective on apoptosis
3. Cell death: The significance of apoptosis
4. Caspases: Killer proteases
5. Caspases and caspase inhibitors
6. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
7. Caspase independent/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis
8. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
9. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
10. Mechanisms controlling cellular suicide: Role of Bcl-2 and caspases
11. BCL-2 family; regulators of cell death
12. Apoptosis and the cell cycle: The p53 connection
13. pRb and the cdks in apoptosis and the cell cycle
14. Phosphorylation-Based signaling in Fas receptor-mediated apoptosis
15. Reversible in vivo phosphorylation of tau induced by okadaic acid and by unspecific brain lesion in rat
16. Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells
17. Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid
18. Protein phosphorylation in apoptosis
19. Novel protein serine/threonine phosphatases: Variety is the spice of life
20. Protein serine/threonine phosphatases; an expanding family
21. Characterization of natural toxins with inhibitory activity against serine/threonine protein phosphatases
22. Unique features of the okadaic acid activity class of tumor promoters
23. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
24. Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line
25. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A
26. Apoptosis and mitotic arrest are two independent effects of the protein phosphatases inhibitor okadaic acid in K562 leukemia cells
27. Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein
28. Doxorubicin-resistant LoVo adenocarcinoma cells display resistance to apoptosis induction by some but not all inhibitors of ser/thr phosphatases 1 and 2A
29. Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors
30. Okadaic acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax
31. Inducible transcription factor expression in a cell culture model of apoptosis
32. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation
33. The apoptosis-inducing activity of the two protein phosphatase inhibitors, tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A
34. Different moieties of tautomycin involved in protein phosphatase inhibition and induction of apoptosis
35. Multidrug-resistant human KB carcinoma cells are highly resistant to the protein phosphatase inhibitors okadaic acid and calyculin A. Analysis of potential mechanisms involved in toxin resistance
36. Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors
37. Human leukemia K562 cell mutant (K562/OA200) selected for resistance to okadaic acid (protein phosphatase inhibitor) lacks protein kinase C-epsilon, exhibits multidrug resistance phenotype, and expresses drug pump P-glycoprotein
38. Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells
39. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells
40. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
41. Efficient screening of retroviral cDNA expression libraries
42. Applications of retrovirus-mediated expression cloning
43. Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death
44. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis
45. Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/caspase-dependent signaling pathway
46. A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity
47. Production of high-titer helper-free retroviruses by transient transfection
48. GenBank
49. DNA Data Bank of Japan in the age of information biology
50. The EMBL Nucleotide Sequence Database
51. A new 34-kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor
52. Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site
53. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation
54. Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A
55. Comparative effects of protein phosphatase inhibitors (okadaic acid and calyculin A) on human leukemia HL60, HL60/ADR and K562 cells
56. Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
57. Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells
58. Cytotoxic drugs and the CD95 pathway
59. Verapamil suppresses the emergence of P-glycoprotein-mediated multi-drug resistance
60. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
61. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
62. Apoptosis: Checkpoint at the mitochondrial frontier
63. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
64. Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis
65. Caspase inhibitors
66. Inhibition of human caspases by peptide-based and macromolecular inhibitors
67. Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors
68. Caspases: Enemies within
69. Cytochrome c: Can't live with it-can't live without it
70. Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2
71. Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release
72. Injected cytochrome c induces apoptosis
73. Caspase structure, proteolytic substrates, and function during apoptotic cell death
74. Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action
75. Ceramide accumulation precedes caspase-dependent apoptosis in CHP-100 neuroepithelioma cells exposed to the protein phosphatase inhibitor okadaic acid
76. New experimental approaches in retrovirus-mediated expression screening
77. Expression cloning of oncogenes by retroviral transfer of cDNA libraries
78. Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor
79. Expression cloning of Isc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors
80. A proinflammatory cytokine inhibits p53 tumor suppressor activity
81. Apaf1 and the apoptotic machinery
82. Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
83. Apoptosis without caspases: An inefficient molecular guillotine?
84. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death
85. Caspase-independent cell killing by Fas-associated protein with death domain
86. Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells
87. Protective effect of the insulin-like growth factor I receptor on apoptosis induced by okadaic acid
88. Insulin and IGF-I receptors signaling in protection from apoptosis
89. Characterisation of a reconstituted Mg-ATP-dependent protein phosphatase
90. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division
91. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos
92. Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction
93. Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1
94. An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases