Cell cycle-independent regulation of p21(Waf1)/(Cip1) and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of bax protein in human breast carcinoma cells

Cell Growth and Differentiation

Volumn 7, Issue 12, 1996, Pages 1599-1607

  Saeed Sheikh, M ^a   Garcia, Marcel ^b   Zhan, Qimin ^a   Liu, Yusen ^c   Fornace Jr , Albert J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INSERM   (France)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL CYCLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ETIOLOGY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA DAMAGE; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; OKADAIC ACID; PHOSPHORIC MONOESTER HYDROLASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

HUMAN PAPILLOMA VIRUS; MINK CELL FOCUS-FORMING VIRUS; PAPILLOMAVIRUS;

EID: 10544250250     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Isaac, J. T. Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer. Curr. Opin. Oncol., 6: 82-89, 1994.
2. Mikulski, S. M. Pathogenesis of cancer in view of mutually opposing apoptotic and anti-apoptotic growth signals. Int. J. Oncol., 4: 1257-1263, 1994.
3. Cleveland, J. L., and Ihle, J. N. Contenders in FasL/TNF death signaling. Cell, 81: 479-482, 1995.
4. Stanger, B. Z., Leeder, P., Lee, T. H., Kim, E., and Seed, B. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell, 81: 513-523, 1995.
5. Cohen, P., Holmes, C. F. B., and Tsukitani, Y. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci., 15: 98-102, 1990.
6. Boe, R., Gjertsen, B. T., Vintermyr, O. K., Houge, G., Lanotte, M., and Doskeland, S. O. The protein phosphatase inhibitor okadaic acid induces morphological changes of typical of apoptosis in mammalian cells. Exp. Cell Res., 195: 237-246, 1991.
7. Kiguchi, K., Glesne, D., Chubb, C. H., Fujiki, H., and Huberman, E. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Cell Growth & Differ., 5: 995-1004, 1994.
8. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
9. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75: 805-816, 1993.
10. Xiong, Y., Hannon, G. J., Zhang, H., Casso, D., Kobayashi, R., and Beach, D. p21 is universal inhibitor of cyclin kinases. Nature (Lond.), 366: 701-704, 1993.
11. Reed, S. I., Bailly, E., Dulic, V., Hengst, L., Resnitzky, D., and Slingerland, J. G1 control in mammalian cells. J. Cell Sci., 18 (Suppl.): 69-73, 1994.
12. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J., Jr. A mammalian cell cycle checkpoint utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell, 71: 587-597, 1992.
13. Hockenbery, D. M. bcl-2 in cancer, development and apoptosis. J. Cell Sci., 18 (Suppl.): 51-55, 1994.
14. Oltavi, Z. N., Miliman, C. L., and Korsmeyer, S. J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74: 609-619, 1993.
15. Sato, T., Hanada, M., Bodrag, S., Irie, S., Iwame, N., Boise, L. H., Thompson, C. B., Colemia, S., Fong, L., Wary, H-G., and Reed, J. Interaction among members of the bcl-2 protein family analyzed by yeast two hybrid system. Proc. Natl. Acad. Sci. USA, 91: 9238-9242, 1994.
16. Chittenden, T., Flemington, C., Houghton, A. B., Ebb, R. G., Gallo, G. J., Elangovan, B., Chinnadurai, G., and Lutz, R. J. A conserved domain in Bak, distinct from BH1 and Bh2, mediates cell death and protein binding functions. EMBO J., 14: 5589-5596, 1995.
17. Bartek, J., Iggo, R., Gannon, J., and Lane, D. P. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene, 5: 893-899, 1990.
18. Vojtesek, B. and Lane, D. P. Regulation of p53 protein expression in human breast cancer cell lines. J. Cell Sci., 105: 607-612, 1993.
19. Zhan, Q., El-Deiry, W., Bae, I., Alamo, I., Jr., Kastan, M. B., Vogelstein, B., and Fornace, A. J., Jr. Similarity of the DNA-damage responsiveness and growth-suppressive properties of WAF1 to GADD45. Int. J. Oncology, 6: 937-946, 1995.
20. Krajewski, S., Blomqvist, C., Franssila, K., Krajewska, M., Wasenius, V. M., Niskanen, E., Nordling, S., and Reed, J. C. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res., 55: 4471-4478, 1995.
21. Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. B. bclx, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74: 597-608, 1993.
22. Haldar, S., Jena, N., and Croce, C. M. Inactivation of bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. USA, 92: 4507-4511, 1995.
23. Hartwell, L. H., and Kastan, M. B. Cell cycle control and cancer. Science (Washington DC), 266: 1821-1828, 1994.
24. Zhan, Q., Fan, S., Smith, M. L., Bae, I., Yu, K., Alamo, I., Jr., O'Connor, P. M., and Fornace, A. J., Jr. Abrogation of p53 function effects the response of gadd genes to DNA base damaging agents and medium starvation. DNA Cell Biol., 15: 805-815, 1996.
25. Fan, S., Smith, M. L., Rivet, D. J., II, Duba, D., Zhan, Q., Kohn, K. W., Fornace, Jr., A. J., and O'Connor, P. M. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res., 55: 1649-1654, 1995.
26. Sheikh, M. S., Li, X. S., Chen, J. C., Shao, Z. M., Ordonez, J. V., and Fontana, J. A. Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. Oncogene, 9: 3407-3415, 1994.
27. Miyashita, T., and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995.
28. Zhan, Q., Fan, S., Bae, I., Guillouf, C., Liebermann, D. A., O'Connor, P. M., and Fornace, A. J., Jr. Induction of BAX by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene, 9: 3743-3751, 1994.
29. Michieli, P., Chedid, M., Lin, D., Pierce, J. H., Mercer, W. E., and Givol, D. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res., 54: 3391-3395, 1994.
30. Biggs, J. R., Kudlow, J. E., and Kraft, A. S. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells. J. Biol. Chem., 271: 901-906, 1996.
31. Han, Z., Chatterjee, D., He, D. M., Early, J., Pantazis, P., Wyche, J. H., and Hendrickson, E. A. Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation. Mol. Cell. Biol. 5849-5857, 1995.
32. Thomas, A., El Rouby, S., Reed, J. C., Krajewski, S., Silber, R., Potmesi, M., and Newcomb, E. W. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene, 1055-1062, 1996.
33. Knudson, C. M., Tung, K. S., Tourtellotte, W. G., Brown, G. A., and Korsmeyer, S. J. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (Washington DC), 270: 96-99, 1995.
34. Chittenden, T., Harrington, E. A., O'Connor, R., Flemington, C., Lutz, R. J., Evan, G. I., and Guild, B. Induction of apoptosis by the Bcl2 homologue Bak. Nature (Lond.), 374: 733-736, 1995.
35. Kiefer, M. C., Brauer, M. J., Powers, V. C., Wu, J. J., Umansky, S. R., Tomei, L. D., and Barr, P. J. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (Lond.), 736-739, 1995.
36. Canman, C. E., Gilmer, T. M., Coutts, S. B., and Kastan, M. B. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev., 9: 600-611, 1995.
37. Cip1. Oncogene, 11: 1675-1683, 1995.
38. Sherr, C. J., and Roberts, J. M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev., 9: 1149-1163, 1995.
39. WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene, 11: 1899-1905, 1995.