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Volumn 4, Issue 4, 1999, Pages 395-401

The apoptosis-inducing activity of the two protein phosphatase inhibitors, tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A (Review)

Author keywords

Apoptosis inducing activity; Phosphatase inhibitors; Tautomycin; Thyrsiferyl 23 acetate

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN INHIBITOR; TAUTOMYCIN; THYRSIFERYL 23 ACETATE; UNCLASSIFIED DRUG; ANTIFUNGAL AGENT; ENZYME INHIBITOR; PYRAN DERIVATIVE; SPIRO COMPOUND; THYRSIFERYL 23-ACETATE;

EID: 0033209692     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.4.4.395     Document Type: Article
Times cited : (8)

References (26)
  • 1
    • 0027272945 scopus 로고
    • Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds
    • Fujiki H and Suganuma M: Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. Adv Cancer Res 61: 143-194, 1993.
    • (1993) Adv Cancer Res , vol.61 , pp. 143-194
    • Fujiki, H.1    Suganuma, M.2
  • 2
    • 0343414631 scopus 로고
    • Inhibitors of eukaryotic protein (serine/threonine) phosphatases: Environmental toxins prove useful in the laboratory
    • MacKintosh C and MacKintosh RW: Inhibitors of eukaryotic protein (serine/threonine) phosphatases: environmental toxins prove useful in the laboratory. Adv Prot Phosphatases 8: 343-354, 1994.
    • (1994) Adv Prot Phosphatases , vol.8 , pp. 343-354
    • MacKintosh, C.1    MacKintosh, R.W.2
  • 3
    • 0030911275 scopus 로고    scopus 로고
    • Tumor promoter and TNF - A gene expression by the okadaic acid class tumor promoters
    • Fujiki H, Sueoka E, Komori A and Suganuma M: Tumor promoter and TNF - A gene expression by the okadaic acid class tumor promoters. Environ Carcinog Rev 15c: 1-40, 1997.
    • (1997) Environ Carcinog Rev , vol.15 C , pp. 1-40
    • Fujiki, H.1    Sueoka, E.2    Komori, A.3    Suganuma, M.4
  • 7
    • 0033584156 scopus 로고    scopus 로고
    • The spiroketal compounds containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity
    • Mitsuhashi S, Shima H, Kawamura T, Kikuchi K, Oikawa M, Ichihara H and Oikawa H: The spiroketal compounds containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity. Bioorg Med Chem Lett 9: 2007- 2012, 1999.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 2007-2012
    • Mitsuhashi, S.1    Shima, H.2    Kawamura, T.3    Kikuchi, K.4    Oikawa, M.5    Ichihara, H.6    Oikawa, H.7
  • 8
    • 0021960098 scopus 로고
    • Teurilene and thyrsiferyl-23-acetate, meso and remarkably cytotoxic compounds from the marine red alga Laurecia obtusa (Hudson) Lamouroux
    • Suzuki T, Suzuki M, Furusaki A, Matsumoto T, Kurosawa E, Kato A and Imanaka Y: Teurilene and thyrsiferyl-23-acetate, meso and remarkably cytotoxic compounds from the marine red alga Laurecia obtusa (Hudson) Lamouroux. Tetrahedron Lett 26: 1329-1332, 1985.
    • (1985) Tetrahedron Lett , vol.26 , pp. 1329-1332
    • Suzuki, T.1    Suzuki, M.2    Furusaki, A.3    Matsumoto, T.4    Kurosawa, E.5    Kato, A.6    Imanaka, Y.7
  • 10
    • 0025340581 scopus 로고
    • The structure of tautomycin, a regulator of eukaryotic cell growth
    • Ubukata M, Cheng XC and Isono K: The structure of tautomycin, a regulator of eukaryotic cell growth. J Chem Soc Chem Commun : 244-246, 1990.
    • (1990) J Chem Soc Chem Commun , pp. 244-246
    • Ubukata, M.1    Cheng, X.C.2    Isono, K.3
  • 11
    • 0025334393 scopus 로고
    • The structure of tautomycin, a dialkylmaleic anhydride antibiotic
    • Cheng XC, Ubukata M and Isono K: The structure of tautomycin, a dialkylmaleic anhydride antibiotic. J Antibiot 43: 809-819, 1990.
    • (1990) J Antibiot , vol.43 , pp. 809-819
    • Cheng, X.C.1    Ubukata, M.2    Isono, K.3
  • 12
    • 0025635610 scopus 로고
    • Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A
    • MacKintosh C and Klumpp S: Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS Lett 277: 137-140, 1990.
    • (1990) FEBS Lett , vol.277 , pp. 137-140
    • MacKintosh, C.1    Klumpp, S.2
  • 13
    • 0025732992 scopus 로고
    • A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle
    • Hori M, Magae J, Han YG, Hartshorne DJ and Karaki H: A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle. FEBS Lett 285: 145-148, 1991.
    • (1991) FEBS Lett , vol.285 , pp. 145-148
    • Hori, M.1    Magae, J.2    Han, Y.G.3    Hartshorne, D.J.4    Karaki, H.5
  • 14
    • 0028806466 scopus 로고
    • Tautomycin: An inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach
    • Suganuma M, Okabe S, Sueoka E, Nishiwaki R, Komori A, Uda N, Isono K and Fujiki H: Tautomycin: an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach. J Cancer Res Clin Oncol 121:621-627, 1995.
    • (1995) J Cancer Res Clin Oncol , vol.121 , pp. 621-627
    • Suganuma, M.1    Okabe, S.2    Sueoka, E.3    Nishiwaki, R.4    Komori, A.5    Uda, N.6    Isono, K.7    Fujiki, H.8
  • 15
    • 0023778309 scopus 로고
    • Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated Guinea-pig cardiac myocytes
    • Hescheler J, Mieskes G, Ruegg JC, Takai A and Trautwein W: Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes. Pflugers Arch 412: 248-252, 1988.
    • (1988) Pflugers Arch , vol.412 , pp. 248-252
    • Hescheler, J.1    Mieskes, G.2    Ruegg, J.C.3    Takai, A.4    Trautwein, W.5
  • 17
    • 0025823502 scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
    • Boe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M and Doskeland SO: The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 195: 237-246, 1991.
    • (1991) Exp Cell Res , vol.195 , pp. 237-246
    • Boe, R.1    Gjertsen, B.T.2    Vintermyr, O.K.3    Houge, G.4    Lanotte, M.5    Doskeland, S.O.6
  • 19
    • 0024361302 scopus 로고
    • An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues
    • Cohen P, Klumpp S and Schelling DL: An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues. FEBS Lett 250: 596-600, 1989.
    • (1989) FEBS Lett , vol.250 , pp. 596-600
    • Cohen, P.1    Klumpp, S.2    Schelling, D.L.3
  • 21
    • 0029965136 scopus 로고    scopus 로고
    • The molecular biology of apoptosis
    • Vaux DL and Strasser A: The molecular biology of apoptosis. Proc Natl Acad Sei USA 93: 2239-2244, 1996.
    • (1996) Proc Natl Acad Sei USA , vol.93 , pp. 2239-2244
    • Vaux, D.L.1    Strasser, A.2
  • 22
    • 0028878377 scopus 로고
    • Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia?
    • Simon HU and Blaser K: Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia? Immunol Today 16: 53-55, 1995.
    • (1995) Immunol Today , vol.16 , pp. 53-55
    • Simon, H.U.1    Blaser, K.2
  • 23
    • 0026539293 scopus 로고
    • Increase in potential activities of protein phosphatases PP1 and PP2A in lymphoid tissues of autoimmune MRL/MpJ-lpr/Ipr mice
    • Matsuzawa S, Tamura T, Mizuno Y, Kobayashi S, Okuyama H, Tsukitani Y, Uemura D and Kikuchi K: Increase in potential activities of protein phosphatases PP1 and PP2A in lymphoid tissues of autoimmune MRL/MpJ-lpr/Ipr mice. J Biochem 111: 472-477, 1992.
    • (1992) J Biochem , vol.111 , pp. 472-477
    • Matsuzawa, S.1    Tamura, T.2    Mizuno, Y.3    Kobayashi, S.4    Okuyama, H.5    Tsukitani, Y.6    Uemura, D.7    Kikuchi, K.8
  • 26
    • 0030035016 scopus 로고    scopus 로고
    • Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor
    • Sugiyama Y, Ohtani I, Isobe M, Takai A, Ubukata M and Isono K: Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor. Bioorg Med Chem 6: 3-8, 1996.
    • (1996) Bioorg Med Chem , vol.6 , pp. 3-8
    • Sugiyama, Y.1    Ohtani, I.2    Isobe, M.3    Takai, A.4    Ubukata, M.5    Isono, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.