Aberrant cell cycle checkpoint function in transformed hepatocytes and WB-F344 hepatic epithelial stem-like cells

Carcinogenesis

Volumn 22, Issue 8, 2001, Pages 1257-1269

  Kaufmann, William K ^a,b   Behe, Cynthia I ^a   Golubovskaya, Vita M ^a   Byrd, Laura L ^a   Albright, Craig D ^c   Borchet, Kristen M ^a   Presnell, Sharon C ^a   Coleman, William B ^a,b   Grisham, Joe W ^a,b   Smith, Gary J ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c IL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; PROTEIN P53;

AGE; ANIMAL CELL; ARTICLE; ATTENUATION; CARCINOGENICITY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL FRACTIONATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; EPITHELIUM CELL; GENOME; HYPOTHESIS; IONIZING RADIATION; LIVER CARCINOGENESIS; LIVER CELL; MITOSIS; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL;

EID: 0034898215     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.8.1257     Document Type: Article

References (72)

1. DNA damage and cell cycle checkpoints
2. Checkpoints: Controls that ensure the order of cell cycle events
3. Cell cycle checkpoints
4. Enhanced phosphorylation of p53 by ATM in response to DNA damage
5. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
6. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
7. 1 arrest
8. 1 cyclin-dependent kinases
9. Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7
10. Regulation of the hepatocyte cell cycle
11. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
12. Universal control mechanism regulating onset of M-phase
13. Animal cell cycles and their control
14. Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation
15. 2 checkpoint function in cells from individuals with familial cancer syndromes
16. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
17. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
18. 2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
19. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
20. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
21. Sacharomyces cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
22. Feedback control of mitosis in budding yeast
23. Mutations of mitotic checkpoint genes in human cancers
24. A p53-dependent mouse spindle checkpoint
25. Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage
26. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
27. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
28. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: Aneuploidy and immortalization
29. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins
30. Defining the molecular mechanisms of human cell immortalization
31. Ataxia telangiectasia: A human mutation with abnormal radiation sensitivity
32. High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia
33. In vitro colonization ability appears soon after initiation of hepatocarcinogenesis in the rat
34. Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations
35. Derivation of phenobarbital-responsive immortal rat hepatocytes
36. TGF-α sustains clonal expansion by promoter-dependent, chemically initiated rat hepatocytes
37. Phenobarbital modulates the type of cell death by rat hepatocytes during deprivation of serum in vitro
38. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells
39. Genomic fluidity is a necessary event preceding the acquisition of tumorigenicity during spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells
40. Telomere shortening, telomerase expression and chromosome instability in rat hepatic epithelial stem-like cells
41. Establishment of a functional HGF/C-MET autocrine loop in spontaneous transformants of WB-F344 rat liver stem-like cells
42. Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium
43. Tumorigenicity of simian virus 40-hepatocyte cell lines: Effect of in vitro and in vivo passage on expression of liver-specific genes and oncogenes
44. 2 checkpoint function and chromosomal destabilization are linked in human fibroblasts expressing human papillomavirus type 16 E6
45. Characterization of cell lines derived from formaldehyde-induced nasal tumors in rats
46. p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions
47. p53-dependent signaling sustains DNA replication and enhances clonogenic survival in 254 nm ultraviolet-irradiated human fibroblasts
48. DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
49. Human cell transformation by simian virus 40. Biologic features of cloned lines
50. 2 checkpoint function precedes human cell immortalization
51. Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene
52. Liver tumor promoter phenobarbital: A biphasic modulator of hepatocyte proliferation
53. DNA synthesis, apoptosis and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion
54. 1 checkpoint function by the non-genotoxic carcinogen phenobarbital
55. Phenotypic and karyotypic changes induced in cultured rat hepatic epithelial cells that express the 'oval' cell phenotype by exposure to N-methyl-N'-nitro-N-nitrosoguanidine
56. Hepatocarcinomas, cholangio-carcinomas and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells. A light- and electron-microscopic analysis
57. Emergence of neoplastic transformants spontaneously or after exposure to N-methyl-N-pm-nitro-N-nitrosoguanidine in populations of rat liver epithelial cells cultured under selective and nonselective conditions
58. A diploid rat liver cell culture. III. Characterization of the heteroploid morphological variants which develop with time in culture
59. Expression of telomerase in normal and malignant rat hepatic epithelia
60. p53 mutations in human cancers
61. Primary cilia cycle in PtK1 cells: Effects of colcemid and taxol on cilia formation and resorption
62. Cell cycle control, DNA repair and initiation of carcinogenesis
63. 1 checkpoint function is not required for induction of apoptosis by acute choline deficiency in immortalized rat hepatocytes in culture
64. Factors influencing the initiation by γ rays of hepatocarcinogenesis in the rat
65. Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia
66. Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment
67. Carcinogenesis in tissue culture. 8. Spontaneous malignant transformation of rat liver cells in long-term culture
68. Hot-spot mutations in the p53 gene of liver nodules induced in rats fed DL-ethionine with a methyl-deficient diet
69. Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein
70. Immune response to cyclin B1 in hepatocellular carcinoma
71. 2 cycle checkpoint in mammalian cells