Telomere shortening, telomerase expression, and chromosome instability in rat hepatic epithelial stem-like cells

Molecular Carcinogenesis

Volumn 24, Issue 3, 1999, Pages 209-217

  Golubovskaya, Vita M ^a,b   Filatov, Leonid V ^a,b   Behe, Cynthia I ^a,b   Presnell, Sharon C ^a   Hooth, Michelle J ^a,b   Smith, Gary J ^a,b   Kaufmann, William K ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Hepatocarcinogenesis; Rat; Stem cell; Telomerase; Telomere

Indexed keywords

TELOMERASE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER GENETICS; CELL AGING; CHROMOSOME ANALYSIS; CYTOGENETICS; ENZYME ACTIVITY; ENZYME REPRESSION; EPITHELIUM CELL; FLUORESCENCE IN SITU HYBRIDIZATION; LIVER CANCER; LIVER CARCINOGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SOUTHERN BLOTTING; STEM CELL; TELOMERE; TRINUCLEOTIDE REPEAT;

ANIMALS; CELL AGING; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; CHROMOSOMES; EPITHELIAL CELLS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER; RATS; RATS, INBRED F344; STEM CELLS; TELOMERASE; TELOMERE;

ANIMALIA; RATTUS RATTUS;

EID: 0032903984     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199903)24:3<209::AID-MC7>3.0.CO;2-F     Document Type: Article

References (52)

1. Zakian VA. Telomeres: Beginning to understand the end. Science 1995;270:1601-1606.
2. Blackburn EH. Structure and function of telomeres. Nature 1991;350:569-573.
3. n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 1988;85:6622-6626.
4. Kipling D, Cooke HJ. Hypervariable ultra-long telomeres in mice. Nature 1990;347:400-402.
5. Makarov VL, Lejnine S, Bedoyan J, Langmore JP. Nucleosomal organization of telomere-specific chromatin in rat. Cell 1993;73:775-787.
6. 3 repeats. Proc Natl Acad Sci USA 1997;94:7423-7428.
7. Olovnikov AM. Principle of marginotomy in template synthesis of polynucleotides. Doklady Biochemistry 1971;201:394-397.
8. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460.
9. Counter CM, Avilion AA, LeFeuvre CE, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992;11:1921-1929.
10. Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985;43:405-413.
11. Blackburn EH. Telomerases. Annu Rev Biochem 1992;61:113-129.
12. Zakian VA. Life and cancer without telomerase. Cell 1997;91:1-3.
13. Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995;269:1236-1241.
14. Gilley D, Blackburn EH. Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase. Mol Cell Biol 1996;16:66-75.
15. Counter CM, Meyerson M, Eaton EN, Weinberg RA. The catalytic subunit of yeast telomerase. Proc Natl Acad Sci USA 1997;94:9202-9207.
16. Lingner J, Hughes TR, Shevchenco A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 1997;276:561-567.
17. Meyerson M, Counter CM, Eaton EN, et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997;90:785-795.
18. Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997;277:955-959.
19. Bodnar AG, Ouellett M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-352.
20. Van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997;385:740-743.
21. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.
22. Harley CB, Kim NW, Prowse KR, et al. Telomerase, cell immortality, and cancer. Cold Spring Harbor Symp Quant Biol 1994; LIX:307-315.
23. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:4240-4248.
24. Rogan EM, Bryan TM, Hukku B, et al. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol Cell Biol 1995;15:4745-4753.
25. Golubovskaya VM, Presnell SC, Hooth MJ, Smith GJ, Kaufmann WK. Expression of telomerase in normal and malignant rat hepatic epithelia. Oncogene 1997;15:1233-1240.
26. Lee LW, Tsao MS, Grisham JW, Smith GJ. Emergence of neoplastic transformants spontaneously or after exposure to N-methyl-N′-nitro-N-nitrosoguanidine in populations of rat liver epithelial cells cultured under selective and nonselective conditions. Am J Pathol 1989;135:63-71.
27. Tsao MS, Smith JD, Nelson KG, Grisham JW. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. Exp Cell Res 1984;154:38-52.
28. Hooth MJ, Vincent JL, Coleman WB, Presnell SC, Grisham JW, Smith GJ. Genomic fluidity is a necessary event preceding the acquisition of tumorigenicity during spontaneous transformation of WB-F344 rat liver epithelial cells. Hepatology 1998;28:78-85.
29. Filatov L, Golubovskaya V, Hurt JC, Byrd LL, Phillips JM, Kaufmann WK. Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein. Oncogene 1998;16:1825-1838.
30. Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
31. Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F. TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 1997;88:875-884.
32. Lansdorp PM, Verwoerd NP, van de Rijke FM, et al. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 1996;5:685-691.
33. Grisham JW, Coleman WB, Smith GJ. Isolation, culture, and transplantation of rat hepatocytic precursor (stem-like) cells. PSEBM 1993;204:270-279.
34. Sargent L, Dragan Y, Xu YH, Sattler G, Wiley J, Pitot HC. Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat. Cancer Res 1996;56:2985-2991.
35. Tsao MS, Grisham JW. Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells. Am J Pathol 1987;127:168-181.
36. Shay JW, Wright WE. The reactivation of telomerase activity in cancer progression. Trends Genet 1996;12:129-131.
37. Greaves M. Is telomerase activity in cancer due to selection of stem cells and differentiation arrest? Trends Genet 1996; 12:127-128.
38. Ohashi K, Tsutsumi M, Kobitsu K, et al. Shortened telomere length in hepatocellular carcinomas and corresponding background liver tissues of patients infected with hepatitis virus. Jpn J Cancer Res 1996;87:419-422.
39. Lee H-W, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998;392:569-574.
40. Nüda N, Matsumoto T, Satoh H, et al Severe growth defect in mouse cells lacking the telomerase RNA component. Nat Genet 1998;19:203-206.
41. Wynford-Thomas D, Kipling D. Cancer and the knockout mouse. Nature 1997;389:551-552.
42. Bryan TM, Marusic L, Bacchetti S, Numba M, Reddel RR. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum Mol Genet 1997;6:921-926.
43. Kaufmann WK, Schwartz JL, Hurt JC, et al. Inactivation of G2 checkpoint function and chromosomal destabilization are linked in human fibroblasts expressing human papillomavirus type 16 E6. Cell Growth Differ 1997;8:1105-1114.
44. Yoshida Y, Kanematsu T, Korenaga D, Sonoda T, Sugimachi K. DNA ploidy of primary hepatocellular carcinoma and pulmonary metastases. Clin Exp Metastasis 1992;10:337-344.
45. n telomeric sequence in vertebrate chromosomes. Chromosoma 1990;99:3-10
46. Wells RA, Germino GG, Krishna S, Buckle VJ, Reeders ST. Telomere-related sequences at interstitial sites in the human genome. Genomics 1998;8:699-704.
47. n. Mamm Genome 1991;1:211-216.
48. Balajee AS, Dominguez I, Bohr VA, Natarajan AT. Analysis of restriction enzyme-induced chromosome aberrations in the interstitial telomeric repeat sequences of CHO and CHE cells by FISH. Mutat Res 1996;372:163-172.
49. Hastie ND, Allshire RC. Human telomeres: Fusion and interstitial sites. Trends Genet 1989;5:326-331.
50. Ashley T, Ward DC. A "hot spot" of recombination coincides with an interstitial telomeric sequence in the Armenian hamster. Cytogenet Cell Genet 1993;62:169-171.
51. Vermeesch JR, Petit P, Speleman F, Devriendt K, Fryns JP, Marynen P. Interstitial telomeric sequences at the junction site of a jumping translocation. Hum Genet 1997;99:735-737.
52. Yamada H, Kuramato T, Serikawa T. A rat genetic linkage map and comparative maps for mouse or human homologous rat genes. Mamm Genome 1994;5:83-88.