Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2- Trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 3, 1998, Pages 281-287

  Escott, Katherine J ^b   Beech, John S ^a   Haga, Kristin K ^a   Williams, Steve C R ^a   Meldrum, Brian S ^a   Bath, Philip M W ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

1 (2 Trifluoromethylphenyl)imidazole; 7 Nitro indazole; Nitric oxide synthase; Rat; Transient middle cerebral artery occlusion

Indexed keywords

1 (2 TRIFLUOROMETHYLPHENYL)IMIDAZOLE; 7 NITROINDAZOLE; ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031940409     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199803000-00006     Document Type: Article

References (49)

1. Ashwal S, Cole DJ, Osborne TN, Pearce WJ (1993) Low dose L-NAME reduces infarct volume in the rat MCAO/reperfusion model. J Neurosurq Anesthesiol 5:241-259
2. Babbedge RC, Bland-Ward PA, Hart SL, Moore PK (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br J Pharmacol 110:225-228
3. Bath PMW, Hassall DG, Gladwin AM, Palmer RMJ, Martin JF (1991) Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis adhesion to endothelium in vitro. Arterioscler Thromb 11:254-260
4. Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM (1986a) Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17:1304-1308
5. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986b) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476
6. Buisson A, Margaill I, Callebert J, Plotkine M, Boulu RG (1993) Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia. J Neurochem 61:690-696
7. Butterworth RJ, Bath PMW (1996) The effect of nitric oxide on platelet function in acute ischaemic stroke (Abstr). Cerebrovasc Dis 6(Suppl 2):6
8. Chen H, Chopp M, Zhang ZG, Garcia JH (1992) The effect of hypothermia on the transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 12:621-628
9. Dalkara T, Moskowitz MA (1994) The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol 4:49-57
10. Dalkara T, Yoshida T, Irikura K, Moskowitz MA (1994) Dual role of nitric oxide in focal cerebral ischemia. Neuropharmacology 33: 1447-1452
11. Dawson DA (1994) Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome. Cerebrovasc Brain Metab Rev 6:299-324
12. Dawson VL, Dawson TMD, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368-6371
13. Escott KJ, Beech JS, Meldrum BS, Williams SCR, Bath PMW (1997) Delayed treatment of reversible focal cerebral ischaemia with 7-nitroindazole in rats. J Hum Hypertens (in press)
14. 19F MRS to the evaluation of a trifluorinated, nitric oxide synthase inhibitor in a rodent model of focal cerebral ischaemia. Submitted to Proceedings of the International Society for Magnetic Resonance in Medicine, 5th Scientific meeting, Vancouver, 1997, pp 1267
15. Hamberg LM, Huang Z, Hunter GJ, Caramia F, Moskowitz MA, Rosen BR (1993) Time effects of L-arginine on cerebral hemodynamics and ischemic volume during acute focal ischemia demonstrated by dynamic MRI. In: Proceedings of the Society of Magnetic Resonance in Medicine, 12th Annual Scientific Meeting, August 1993, New York, Vol. 1, pp 397
16. Handy RLC, Harb HL, Wallace P, Gaffen ZA, Whitehead KJ, Moore PK (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects: Br J Pharmacol 119:423-431
17. Handy RLC, Wallace P, Gaffen ZA, Whitehead KJ, Moore PK (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol 116:2349-2350
18. Hara H, Huang PL, Panahian N, Fishman MC, Moskowitz MA (1996) Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J Cereb Blood Flow Metab 16:605-611
19. Huang, Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885
20. Huang Z, Huang PL, Fishman MC, Moskowitz MA (1996) Focal cerebral ischemia in mice deficient in either endothelial (eNOS) or neuronal nitric oxide (nNOS) synthase (Abstr). Stroke 27:173
21. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA (1994) Nitricoxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 14:175-192
22. Iadecola C, Zhang F, Zu S (1995a) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage Am J Phvsiol 268:R286-R292
23. Iadecola C, Zhang F, Zu S, Casey R, Ross ME (1995b) Inducible nitricoxide synthase expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 15:378-384
24. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema: 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8:1-8
25. Kumura E, Kosaka H, Shiga T, Yoshimine T, Hayakawa T (1994) Elevation of plasma nitric oxide end products during focal cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab 14:487-491
26. Malinski T, Bailey F, Zhang ZG, Chopp M (1993) Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 13:355-358
27. Manzoni O, Prezeau L, Marin P, Deshager S, Bockaert J, Fagni L (1992) Nitric oxide-induced blockade of NMDA receptors. Neuron 8:653-662
28. Meldrum BS (1996) The role of nitric oxide in ischemic damage. In: Advances in Neurology. Vol. 17: Cellular and Molecular Mechanisms of Ischemic Brain Damage (Siesjö BK, Wieloch T, eds), Philadelphia, Lippincott-Raven, pp 355-363
29. Moncada S, Palmer MJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142
30. Moore PK, Babbedge RC, Wallace P, Gaffen ZA, Hart SL (1993a) 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol 108:296-297
31. Moore PK, Wallace P, Gaffen ZA, Hart SL, Babbedge RC (1993b) Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol 110:219-224
32. Morikawa E, Huang Z, Moskowitz MA (1992a) L-Arginine decreases infarct size caused by middle cerebral artery occlusion in SHR. Am J Physiol 263:H1632-H1635
33. Morikawa E, Rosenblatt S, Moskowitz MA (1992b) L-Arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischemia. Br J Pharmacol 107:905-907
34. Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dalkara T (1994) L-Arginine promotes nitric oxide-dependent vasodilation. increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 25:429-435
35. ω-nitro-L-arginine mitigates ischemic brain edema and subsequent cerebral infarction in rats. Neurosci Lett 147:159-162
36. Nowicki JP, Duval D, Poignet H, Scatton B (1991) Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur J Pharmacol 204:339-340
37. Prado R, Watson BD, Zhao W, Yao H, Busto R, Dietrich WD, Ginsberg MD (1996) L-Arginine does not improve cortical perfusion or histological outcome in spontaneously hypertensive rats subjected to distal middle cerebral artery photothrombotic occlusion. J Cereb Blood Flow Metab 16:612-622
38. Radi R, Beckman JS, Bush KM, Freeman BA (1991) Peroxynitrite oxidation of sulfhydryls. J Biol Chem 266:4244-4250
39. Radomski MW, Palmer RMJ, Moncada S (1987) Endogenous nitric-oxide inhibits human platelet adhesion to vascular endothelium. Lancet 2:1057-1058
40. Rees DD, Palmer RMJ, Moncada S (1991) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86:3375-3378
41. Smith SE, Man CM, Yip PK, Tang E, Chapman AG, Meldrum, BS (1996) Anticonvulsant effects of 7-nitro indazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation. Br J Pharmacol 119:165-173
42. Stadler J, Billiar TR, Curran RD, Stuehr DJ, Ochoa JB, Simmons RL (1991) Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol 260:C910-C916
43. Yoshida T, Limmroth V, Irikura K, Moskowitz MA (1994) The NOS inhibitor. 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. J Cereb Blood Flow Metab 14:924-929
44. Zea Longa E, Weinstein PR, Carlson A, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
45. Zhang F, Iadecola C (1993) Nitroprusside improves blood flow and reduces brain damage after focal ischemia. Neuroreport 4:559-562
46. Zhang F, Iadecola C (1994) Reduction of focal cerebral ischemic damage by delayed treatment with nitric oxide donors. J Cereb Blood Flow Metab 14:574-580
47. Zhang F, White JG, Iadecola C (1994) Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab 14:217-226
48. Zhang F, Casey RM, Ross ME, Iadecola C (1996a) Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. Stroke 27:317-323
49. Zhang ZG, Reif D, Macdonald J, Tang WX, Kamp DK, Gentile RJ, Shakespeare WC, Murray RJ, Chopp M (1996b) ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient cerebral artery occlusion in rats. J Cereb Blood Flow Metab 16:599-604