Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo

European Journal of Pharmacology

Volumn 303, Issue 1-2, 1996, Pages 61-69

  Zagvazdin, Yuri ^a   Sancesario, Giuseppe ^c   Wang, Yi Xin ^a   Share, Leonard ^a   Fitzgerald, Malinda E C ^a,b   Reiner, Anton ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b CHRISTIAN BROTHERS UNIVERSITY   (United States)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

7 Nitroindazole; Acetylcholine; Arterial pressure, systemic; Nitric oxide (NO) synthase; Sodium nitroprusside

Indexed keywords

7 NITROINDAZOLE; ACETYLCHOLINE; ARGININE; CHLORALOSE; HALOTHANE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; URETHAN;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DEPRESSOR RESPONSE; DOSE TIME EFFECT RELATION; DRUG INHIBITION; HEART RATE; HYPOTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

EID: 0029898108     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00106-9     Document Type: Article

References (36)

1. Aisaka, K., S.S. Gross, O.W. Griffith and R. Levi, 1989, L-Arginine availability determines the duration of acetylcholine induced systemic vasodilation in vivo, Biochem. Biophys. Res. Commun. 163, 710.
2. Babbedge, R.C., P.A. Bland-Ward, S.L. Hart and P.K. Moore, 1993, Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles, Br. J. Pharmacol. 110, 225.
3. Biaise, G., Q. To, M. Parent, B. Legarde, F. Asenjo, R. Sauve, 1994, Does halothane interfere with the release, action or stability of endothelium-derived relaxing factor/nitric oxide?, Anesthesiology 80, 417.
4. Calver, A., J. Collier and P. Vallance, 1993, Nitric oxide and cardiovascular control, Exp. Physiol. 78, 303.
5. Cholet, N., G. Bonvento and J. Seylaz, 1995, Effect of neuronal nitric oxide synthase inhibition on cerebrovascular response to somatosensory stimulation, Abstr. Soc. Neurosci. 21, 433.
6. ω-nitro-L-arginine methyl ester on arterial pressure and on vasodilator and vasoconstrictor responses: influence of initial vascular tone, Eur. J. Pharmacol. 212, 159.
7. Dinerman, J.L., C.J. Lowenstein and S.H. Snyder, 1993, Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease, Circ. Res. 73, 217.
8. Forstermann, U., J.S. Pollock and M. Nakane, 1993, Nitric oxide synthases in the cardiovascular system, Trends Cardiovasc. Med. 3, 104.
9. g-nitro-L-arginine methyl ester, Br. J. Pharmacol. 101, 632.
10. s-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5′-N-ethylcarboxamidoadenosine or salbutamol in conscious rats, Br. J. Pharmacol. 103, 1725.
11. Globus, M.Y.-T., W.D. Dietrich, S. Kraydieh, I. Garcia and R. Busto, 1995, Effects of postischemic treatment with specific and non-specific nitric oxide synthase inhibitors on histopathological outcome following transient global ischemia, J. Cereb. Blood Flow Metab. 15 (Suppl. 1), S440.
12. Greenblatt, E.P., A.L. Loeb and D.E. Longnecker, 1993, Marked regional heterogeneity in the magnitude of EDRF/NO-mediated vascular tone in awake rats, J. Cardiovasc. Pharmacol. 21, 235.
13. Grome, J.J., P.A.T. Kelly and I.M. Ritchie, 1995, Effects of the atypical nitric oxide synthase inhibitor, 7-nitroindazole (7-NI) on cerebral blood flow-metabolism coupling and infarct size, J. Cereb. Blood Flow Metab. 15 (Suppl. 1), S142.
14. Huang, Z., P.L. Huang, N. Panahian, T. Dalkara., M.C. Fishman and M.A. Moskowitz, 1994, Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase, Science 265, 1883.
15. Huang, P.L., Z. Huang, H. Mashimo, K.D. Bloch, M.A. Moskowitz, J.A. Bevan and M.C. Fishman, 1995, Hypertension in mice lacking the gene for endothelial nitric oxide synthase, Nature 377, 239.
16. Kamii, H., S. Mikawa, H. Kinouchi, T. Yoshimoto, L. Reola, E. Carlson, C.J. Epstein and P.H. Chan, 1995, Effects of nitric oxide synthase inhibition on brain infarction in SOD-1 transgenic mice following transient focal cerebral ischemia, J. Cereb. Blood Flow Metab. 15 (Suppl. 1), S89.
17. Kelly, P.A.T., I.M. Ritchie and G.W. Arbuthnott, 1995, Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: effects upon local cerebral blood flow and glucose use in the rat, J. Cereb. Blood Flow Metab. 15, 766.
18. Kovach, A.G.B., Z. Lohinai, J. Marczis, M. Reivich, T.M. Dawson and S.H. Snyder, 1994, The effect of hemorrhagic hypotension and retransfusion and 7-nitro-indazole on rCBF, NOS catalytic activity and cortical NO content in the cat, Ann. NY Acad. Sci. 738, 348.
19. Moncada, S., R.M.J. Palmer and E.A. Higgs, 1991, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43, 109.
20. Montecot, C., E. Pinard, S. Peres, J. Borredon and J. Seylaz, 1995, 7-nitroindazole (7-NI), a neuronal NO synthase (NOS) inhibitor, blocks the cortical hyperemia in kainate-induced seizures, J. Cereb. Blood Flow Metab. 15 (Suppl. 1), S436.
21. Moore, P.K., P. Wallace, Z. Gaffen, S.L. Hart and R.C. Babbedge, 1993, Characterization of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects, Br. J. Pharmacol. 110, 219.
22. ω-nitro-L-arginine methyl ester administration, J. Cardiovasc. Pharmacol. 23, 765.
23. O'Shaugnessey, K.M., C.M. Newman and J.B. Warren, 1992, Inhibition in the rat of nitric oxide synthesis in vivo does not not attenuate the hypotensive action of acetylcholine, ATP or bradykinin, Exp. Physiol. 77, 285.
24. Pegoraro, A.A., O.A. Carretero, D.H. Sigmon and W.H. Beirwaltes, 1992, Sympathetic modulation of endothelium-derived relaxing factor, Hypertension 19, 643.
25. 2 responsiveness of the cerebral and spinal cord vessels of the cat, J. Cereb. Blood Flow. Metab. 14, 49.
26. Sigmon, D.H., I. Florentino-Pineda, R.A. Van Dyke and W. Beirwaltes, 1995, Halothane impairs the hemodynamic influence of endothelium-derived nitric oxide, Anesthesiology 82, 135.
27. Umans, J.G. and R. Levi, 1995, Nitric oxide in the regulation of blood flow and arterial pressure, Annu. Rev. Physiol. 57, 771.
28. g-nitro-L-arginine methyl ester in rats and cats, Br. J. Pharmacol. 103, 1899.
29. g-Nitro-L-arginine methyl ester: systemic and pulmonary haemodynamics, tissue blood flow and arteriovenous shunting in the pig, Naunyn-Schmied. Arch. Pharmacol. 348, 417.
30. Wang, Y.X., and C.C.Y. Pang, 1993, Halothane inhibits the pressor effect of diphenyleneiodonium, Br. J. Pharmacol. 109, 1186.
31. g-nitro-L-arginine, Eur. J. Pharmacol. 198, 183.
32. g-nitro-L-arginine by halothane, J. Cardiovasc. Pharmacol. 22, 571.
33. g-nitro-L-arginine methyl ester in vitro and in vivo, J. Pharmacol. Exp. Ther. 267, 1091.
34. Yoshida, T., V. Limmroth, K. Irikura and M.A. Moskowitz, 1994, The NO synthase inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. J. Cereb. Blood Flow Metab. 14, 924.
35. Zagvazdin, Y., G. Sancesario, M.E.C. Fitzgerald and A. Reiner, 1994, The effect of 7-nitroindazole, an inhibitor of brain nitric oxide synthase (NOS), on basal cortical blood flow and on vasodilation induced by whisker stimulation, Abstr. Soc. Neurosci. 2, 999.
36. Zagvazdin, Y., M.E.C. Fitzgerald, G. Sancesario and A. Reiner, 1996, Neural nitric oxide mediates Edinger-Westphal nucleus evoked increase in choroidal blood flow in pigeon, Invest. Ophthalmol. Visual Sci. 37, 666.