Function of the inv(16) fusion gene CBFB-MYH11

Current Opinion in Hematology

Volumn 8, Issue 4, 2001, Pages 201-205

  Kundu, Mondira ^a   Liu, Pu Paul ^a,b  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CBFB MYH11 PROTEIN; CORE BINDING FACTOR; DNA FRAGMENT; HYBRID PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CHROMOSOME INVERSION; CHROMOSOME INVERSION 16; CHROMOSOME REARRANGEMENT; DNA DAMAGE; EOSINOPHIL; GENE FUNCTION; GENE FUSION; HEMATOPOIESIS; HEMATOPOIETIC CELL; IN VITRO STUDY; INTRACELLULAR TRANSPORT; LEUKEMOGENESIS; MYELOID LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW; TRANSACTIVATION;

ANIMALS; CORE BINDING FACTOR ALPHA SUBUNITS; CORE BINDING FACTOR BETA SUBUNIT; DNA-BINDING PROTEINS; HEMATOPOIESIS; INVERSION, CHROMOSOME; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MICE; ONCOGENE PROTEINS, FUSION; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS;

EID: 0034886626     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200107000-00004     Document Type: Review

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8. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
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20. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta
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24. Lineage- and stage-specific expression of runt box polypeptides in primitive and definitive hematopoiesis
25. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11
26. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
27. Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage
28. The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia
29. Mutations which accelerate G1 cooperate with Cbfb-SMMHC to induce acute myeloid leukemia
30. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
31. p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
32. The leukemogenic function of the inv(16) fusion gene CBFB-MYH11
33. Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells
34. Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF
35. Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia- related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation
36. The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates
37. The PEBP2beta/CBF beta-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16
38. The core binding factor (CBF) alpha interaction domain and the smooth muscle myosin heavy chain (SMMHC) segment of CBFbeta-SMMHC are both required to slow cell proliferation
39. Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit
40. Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail
41. The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation
42. The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor
43. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
44. CBF beta-SMMHC, expressed in M4Eo AML reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells
45. CBF oncoproteins slow the G1 to S phase cell cycle transition by decreasing CDK4 RNA levels
46. Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - A model for overcoming inhibition of proliferation by CBF oncoproteins
47. CBFbeta-SMMHC, expressed in M4eo acute myeloid leukemia, reduces p53 induction and slows apoptosis in hematopoietic cells exposed to DNA- damaging agents
48. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin- proteosome-mediated degradation