CBF - A biophysical perspective

Seminars in Cell and Developmental Biology

Volumn 11, Issue 5, 2000, Pages 377-382

  Bushweller, John H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

AML1; CBF; Core binding factor; Hematopoiesis; Leukemia; Runx; Structure

Indexed keywords

CORE BINDING FACTOR; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX; UNCLASSIFIED DRUG;

BINDING AFFINITY; BINDING SITE; BIOPHYSICS; DNA BINDING; HEMATOPOIESIS; HUMAN; LEUKEMIA; LEUKEMOGENESIS; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; STOICHIOMETRY; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

EID: 0034489975     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.2000.0182     Document Type: Article

References (35)

1. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α
2. PEBP2/PEA2 represents a new family of transcription factor homologous to the products of the Drosophila runt and the human AML1 gene
3. The Runt-domain identifies a new family of heteromeric DNA-binding transcriptional regulatory proteins
4. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
5. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
6. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
7. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
8. Indirect and direct disruption of transcriptional regulation in cancer, E2F, and AML-1
9. Biochemical and biophysical properties of the CBFα2 (AML1) DNA-binding domain
10. Biophysical characterization of interactions between the core binding factor α and β subunits and DNA
11. Overexpression, purification, and biophysical characterization of the heterodimerization domain of core-binding factor β subunit
12. CBFB and CBFB-SMMHC function in definitive hematopoiesis
13. The leukemic protein core binding factor B (CBFB)-smooth-muscle myosin heavy chain sequesters CBFA2 into cytoskeletal filaments and aggregates
14. Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein2/core binding factor α subunit revealed in the presence of the β subunit
15. Auto-inhibition and partner proteins, CBFβ and Ets-1, modulate DNA binding by CBFα2(AML1)
16. Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains
17. Solution structure of core binding factor β and map of the CBFα binding site
18. Molecular insights into PEBP2/CBFB-SMMHC associated leukemia revealed from the structure of PEBP2/CBFB
19. The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig fold DNA binding domains
20. Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
21. A simple screening for mutant DNA binding proteins: Application to murine transcription factor PEBP2α subunit, a founding member of the Runt domain protein family
22. Functional dissection of the α and β subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity
23. Functional domains of the t(8;21) fusion protein, AML-1/ETO
24. Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt
25. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core binding factor
26. Crystal structure of the nuclear matrix targeting signal of the transcription factor Acute Myelogenous Leukemia-1/Polyoma Enhancer-binding Protein 2αB/Core Binding Factor α2
27. Multiprotein-DNA complexes in transcriptionalregulation
28. Auto-inhibition and partner proteins, CBFβ and Ets-1, modulate DNA binding by CBFα2(AML1)
29. Multiple functional domains of AML1: PU.1 and C/EBPα synergize with different regions of AML1
30. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRα function
31. Transcriptional repression by AML1 and LEF-I is mediated by the TLE/Groucho corepressors
32. Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dc13 by ear-2, mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO (MTG8)
33. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
34. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFβ