p53 oncogene mutations in three human prostate cancer cell lines

The Prostate

Volumn 23, Issue 2, 1993, Pages 123-134

  Carroll, Alan G ^a   Voeller, H James ^a   Sugars, Lavencia ^a   Gelmann, Edward P ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

DU 145; LNCaP; p53; PC 3; suppressor oncogene

Indexed keywords

PROTEIN P53;

ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CHROMOSOME 17P; CHROMOSOME ANALYSIS; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; PROSTATE CANCER; REGULATOR GENE; TUMOR GROWTH;

EID: 0027494237     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.2990230206     Document Type: Article

References (27)

1. Genetic analysis of human esophageal tumors from two high incidence geographic areas: Frequent p53 base substitutions and absence of ras mutations
2. Mutational hotspot in the p53 gene in human hepatocellular carcinomas
3. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
4. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens
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6. Alterations of the p53 gene are associated with the progression of a human prostate carcinoma
7. Carcinoma of the prostate
8. Establishment and characterization of a human prostatic carcinoma cell line (PC‐3)
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11. LNCaP model of human prostatic carcinoma
12. Aberrant response in vitro of hormone‐responsive prostate cancer cells to antiandrogens
13. v‐ras‐H expression confers hormone‐independent in vitro growth to LNCaP prostate carcinoma cells
14. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
15. p53 Gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
16. A mapped set of DNA markers for human chromosome 17
17. Deletion mapping of the medulloblastoma locus on chromosome 17p
18. Mutations in the p53 gene occur in diverse human tumour types
19. Detection of point mutations in type I collagen by R Nase digestion of RNA/RNA hybrids
20. Activating mutations for transformation by p53 produce a gene product that forms an hsc70‐p53 complex with an altered half‐life
21. Growth suppression of human breast cancer cells by the introduction of a wild‐type p53 gene
22. Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing
23. A nonsense mutation causing decreased levels of insulin receptor mRNA: Detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction
24. Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes
25. p53 Mutations, ras mutations, and p53‐heat shock 70 protein complexes in human lung carcinoma cell lines
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