Calcitonin receptor-mediated growth suppression of HEK-293 cells is accompanied by induction of p21(WAF1/CIP1) and G2/M arrest

Molecular Endocrinology

Volumn 13, Issue 10, 1999, Pages 1738-1750

  Evdokiou, Andreas ^a   Raggatt, Liza Jane ^a   Atkins, Gerald J ^a   Findlay, David M ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CALCITONIN RECEPTOR; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL GROWTH; CELL PROLIFERATION; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOSIS INDEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM;

EID: 0033305327     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.10.0359     Document Type: Article

References (44)

1. Calcitonin alters behaviour of isolated osteoclasts
2. Calcitonin
3. Hormone receptors
4. G protein-coupled receptor systems involved in cell growth and oncogenesis
5. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia
6. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
7. Identification of brain isoforms of the rat calcitonin receptor
8. Cloning and characterization of an abundant subtype of the human calcitonin receptor
9. Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript
10. Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line
11. 2+ transients
12. Calcitonin binding and degradation in two cultured human breast cancer lines (MCF-7 and T47D)
13. Calcitonin and 1,25-dihydroxyvitamin D receptors in human breast cancer cell lines
14. Calcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers
15. Calcitonin effects on growth and on selective activation of type II isoenzyme of cyclic adenosine 3';5'-monophosphate-dependent protein kinase in T47D human breast cancer cells
16. Cell signalling pathway involved in PACAP-induced AR4-2J cell proliferation
17. Vasoactive intestinal peptide enhances immunoglobulin production and growth in human plasma cells via mechanisms that may involve protein kinase C
18. Regulation of c-fos and c-jun expression by calcitonin in human breast cancer cells
19. Calcitonin directly acts on mouse osteoblastic MC3T3-E1 cells to stimulate mRNA expression of c-fos, insulin-like growth factor-1 and osteoblastic phenotypes (type I collagen and osteocalcin)
20. Expression of p(27Kip1) in osteoblast-like cells during differentiation with parathyroid hormone
21. Genetic determinants of p53-induced apoptosis and growth arrest
22. Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases
23. The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation
24. Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation
25. Expression cloning and receptor pharmacology of human calcitonin receptors from MCF-7 cells and their relationship to amylin receptors
26. Universal control mechanism regulating onset of M phase
27. Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity
28. Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation
29. Parathyroid hormone inhibits mitogen-activation in osteosarcoma cells via a protein kinase A-dependent pathway
30. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development
31. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
32. Mitogenic signalling via G protein-coupled receptors
33. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
34. New functional activities for the p21 family of CDK inhibitors
35. p21 Is a universal inhibitor of cyclin kinases
36. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21
37. Cyclins and cyclin-dependent kinases: Take your partners
38. Animal cell cycles and their control
39. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line
40. Activation of p53-p21(waf1) pathway in response to disruption of cell-matrix interactions
41. Mechanisms of regulation of WAF1/ Cip1 gene expression in human breast carcinoma: Role of p53-dependent and independent signal transduction pathways
42. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
43. The effect of calcitonin on the prechordal mesoderm, neural plate and neural crest of Xenopus embryo
44. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells