Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizer

Development

Volumn 128, Issue 15, 2001, Pages 2975-2987

  Yao, J ^a   Kessler, D S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Goosecoid; Homeobox; Repression; Spemann's organizer; Transcription; Wnt; Xenopus

Indexed keywords

ACTIVIN; ETOPOSIDE; HOMEODOMAIN PROTEIN; PROTEIN INHIBITOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; WNT PROTEIN;

ANIMAL TISSUE; ANTERIOR POSTERIOR AXIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; EMBRYO AXIS; EMBRYO CELL; EMBRYO DEVELOPMENT; EXPLANT; GENETIC TRANSCRIPTION; HEAD; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRUNK; VERTEBRATE; XENOPUS;

ANIMALS; CULTURE TECHNIQUES; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GOOSECOID PROTEIN; HEAD; HERPES SIMPLEX VIRUS PROTEIN VMW65; HOMEODOMAIN PROTEINS; NERVOUS SYSTEM; ORGANIZERS, EMBRYONIC; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TAIL; TRANSCRIPTION FACTORS; WNT PROTEINS; XENOPUS; ZEBRAFISH PROTEINS;

ANIMALIA; VERTEBRATA;

EID: 0034883270     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (98)

1. -/- mutants due to a defective anterior neuroectoderm specification during gastrulation
2. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
3. Interaction of goosecoid and brachyury in Xenopus mesoderm patterning
4. Anterior patterning in mouse
5. Axis development and early asymmetry in mammals
6. The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants
7. Anterior neurectoderm is progressively induced during gastrulation: The role of the Xenopus homeobox gene orthodenticle
8. Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation
9. Gastrulation in the mouse: The role of the homeobox gene goosecoid
10. Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1
11. Organizer-specific homeobox genes in Xenopus laevis embryos
12. Ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin
13. Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra
14. The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
15. Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid
16. Isolation of cDNAs partially encoding four Xenopus wnt-1/int-1 related proteins and characterization of their transient expression during embryonic development
17. Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus
18. Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
19. Bone Morphogenetic Protein 4: A ventralizing factor in Xenopus development
20. Negative autoregulation of the organizer-specific homeobox gene goosecoid
21. The evolution of vertebrate gastrulation
22. The establishment of Spemann's organizer and patterning of the vertebrate embryo
23. Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis
24. Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus
25. On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo
26. Antimorphic goosecoids
27. Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis
28. Xwnt-8 and lithium can act upon either dorsal mesodermal or neurectodermal cells to cause a loss of forebrain in Xenopus embryos
29. Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall
30. Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus
31. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo
32. Functional domains of the Drosophila Engrailed protein
33. DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9
34. Formation and function of Spemann's organizer
35. Cephalic expression and molecular characterization of Xenopus En-2
36. Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP-2 and BMP-4
37. Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos
38. BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm
39. MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos
40. The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm
41. Active repression of transcription by the engrailed homeodomain protein
42. DVR-4 (Bone Morphogenetic Protein-4) as a posteroventralizing factor in Xenopus mesoderm induction
43. Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos
44. Siamois is required for formation of Spemann's organizer
45. Monoclonal antibodies identify blastemal cells derived from dedifferentiating muscle in newt limb regeneration
46. The first cleavage furrow demarcates the dorsal-ventral axis in Xenopus embryos
47. Opl: A zinc finger protein that regulates neural determination and patterning in Xenopus
48. The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins
49. Goosecoid and mix.1 repress Brachyury expression and are required for head formation in Xenopus
50. The vertebrate organizer: Structure and molecules
51. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
52. Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators
53. Uber die Induktionsfahigkeit der verschiedenen Bezirke der Neurula von Urodelen
54. The specificity of homeotic gene function
55. Mouse Otx2 functions in the formation and patterning of rostral head
56. Structural and functional analysis of the BMP-4 promoter in early embryos of Xenopus laevis
57. Head in the WNT: The molecular nature of Spemann's head organizer
58. Reorganizing the organizer 75 years on
59. Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm
60. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
61. Gradual refinement of activin-induced thresholds requires protein synthesis
62. Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
63. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
64. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors
65. Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development
66. Xenopus embryos regulate the nuclear localization of XMyoD
67. GAL4-VP16 is an unusually potent transcriptional activator
68. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
69. Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo
70. The homeodomain transcription factor Xvent-2 mediates autocatalytic regulation of BMP-4 expression in Xenopus embryos
71. Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos
72. Requirement for Lim1 in head-organizer function
73. A conserved region of engrailed, shared among en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active repression in vivo
74. Analysis of Dishevelled signalling pathways during Xenopus development
75. Uber Induktion von Embryonanlagen durch Implantation artfremder Organisatoren
76. Uber den Anteil von Implantat und Wirtskeim an der Orientierung and Beschaffenheit der induzierten Embryonalanlage
77. Xenopus axis formation: Induction of goosecoid by injected Xwnt-8 and activin mRNAs
78. The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: A loss-of-function study using antisense RNA
79. A truncated BMP receptor affects dorsal-ventral patterning in the early Xenopus embryo
80. Analysis of competence and of Brachyury autoinduction by use of hormone-inducible Xbra
81. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo
82. Post-transcriptional regulation of Xwnt-8 expression is required for normal myogenesis during vertebrate embryonic development
83. A single amino acid can determine the DNA binding specificity of homeodomain proteins
84. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
85. Blastomere derivation and domains of gene expression in the Spemann Organizer of Xenopus laevis
86. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
87. Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts-3A, -5A, or -11
88. Cooperative dimerization of paired class homeo domains on DNA
89. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication
90. Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death
91. Nasal and pharyngeal abnormalities caused by the mouse goosecoid gene mutation
92. Mesoderm induction in Xenopus: Oocyte expression system and animal cap assay
93. Malformation of trachea and pelvic region in goosecoid mutant mice
94. Goosecoid regulates the neural inducing strength of the mouse node
95. The Spemann organizer of Xenopus is patterned along its anteroposterior axis at the earliest gastrula stage