Escherichia coli cytotoxic necrotizing factor and Pasteurella multocida toxin induce focal adhesion kinase autophosphorylation and Src association

Infection and Immunity

Volumn 69, Issue 9, 2001, Pages 5931-5935

  Thomas, W ^a   Pullinger, G D ^a   Lax, A J ^a   Rozengurt, E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CYTOTOXIC FACTOR; CYTOTOXIC NECROTIZING FACTOR; FOCAL ADHESION KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; COMPLEX FORMATION; ENZYME PHOSPHORYLATION; ESCHERICHIA COLI; NONHUMAN; PASTEURELLA MULTOCIDA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CYTOTOXINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; MICE; PASTEURELLA MULTOCIDA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SRC-FAMILY KINASES; TYROSINE;

EID: 0034877755     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.9.5931-5935.2001     Document Type: Article

References (55)

1. Identification of a putative target for Rho as the serine-threonine kinase protein kinase N
2. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
3. Focal adhesions: Contractility and signaling
4. Cytotoxic necrotizing factor production by hemolytic strains of Escherichia coli causing extraintestinal infections
5. Partial purification and characterization of ah Escherichia coli toxic factor that induces morphological cell alterations
6. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration
7. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
8. Immunochemical identification and biological characterization of cytotoxic necrotizing factor from Escherichia coli
9. Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase
10. Escherichia coli cytotoxic necrotizing factor 1: Evidence for induction of actin assembly by constitutive activation of the p21 Rho GTPase
11. Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine
12. Control of adhesion-dependent cell survival by focal adhesion kinase
13. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
14. Signaling through focal adhesion kinase
15. CAS, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
16. Pasteurella multocida toxin is a potent inducer of anchorage-independent cell growth
17. Inhibition of pp125FAK in cultured fibroblasts results in apoptosis
18. Focal adhesion kinase: At the crossroads of signal transduction
19. Reduced cell motility and enhanced focal contact formation in cells from FAK-deficient mice
20. The small GTP-binding protein Rho binds to and activates a 160-kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
21. p160/ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
22. FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells
23. rho-dependent tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 cells
24. Molecular localization of the Escherichia coli cytotoxic necrotizing factor CNF1 cell-binding and catalytic domains
25. Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: Activation of c-Jun N-terminal kinase in HeLa cells
26. The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton
27. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
28. Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin
29. Pasteurella multocida toxin selectively facilitates phosphatidylinositol 4,5-bisphosphate hydrolysis by bombesin, vasopressin, and endothelin
30. Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
31. Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways
32. Protein modules and signaling networks
33. Interaction between focal adhesion kinase and Crk-associated tyrosine substrate p130Cas
34. Rhotekin, a new putative target for rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain
35. Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells
36. Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells
37. Convergent signaling in the action of integrins, neuropeptides, growth factors and oncogenes
38. Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists
39. Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells
40. Pasteurella multocida toxin: Potent mitogen for cultured fibroblasts
41. Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells
42. The rho-deamidating cytotoxic necrotizing factor 1 from Escherichia coli possesses transglutaminase activity
43. Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1
44. q/11-dependent transactivation of the epidermal growth factor receptor
45. Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor
46. 2+ in Swiss 3T3 cells
47. Pasteurella multocida toxin, a potent mitogen, stimulates protein kinase C-dependent and -independent protein phosphorylation in Swiss 3T3 cells
48. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates
49. SH2- and SH3-mediated interactions between focal adhesion kinase and Src
50. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
51. Activity of the mitogenic Pasteurella multocida toxin requires an essential C-terminal residue
52. Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
53. qα-coupled phospholipase C-β1
54. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells
55. Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes