Measuring electrophysiological changes in transgenic mouse models of cardiovascular disease

Cardiovascular Research

Volumn 51, Issue 4, 2001, Pages 630-632

  Eisenberg, Carol A ^a   Eisenberg, Leonard M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Connexin; Electrophysiology; Heart; Optical mapping

Indexed keywords

CONNEXIN 40; CONNEXIN 43; CONNEXIN 45;

CARDIOVASCULAR DISEASE; EDITORIAL; ELECTROCARDIOGRAM; HEART ARREST; HEART ARRHYTHMIA; HEART CYCLE; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HEART MUSCLE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; TRANSGENIC MOUSE;

ANIMALS; CARDIOVASCULAR DISEASES; CONNEXIN 43; CONNEXINS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; HEART; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION;

EID: 0034862181     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00397-2     Document Type: Editorial

References (26)

1. Diverse functions of vertebrate gap junctions
2. Genetic diseases and gene knockouts reveal diverse connexin functions
3. The cardiac muscle cell
4. Electrophysiological effects of remodeling cardiac gap junctions and cell size: Experimental and model studies of normal cardiac growth
5. Connexins and impulse propagation in the mouse heart
6. Gap junctions and heart development
7. Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system
8. Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
9. Connexin45 (α6) expression delineates an extended conduction system in embryonic and mature rodent heart
10. Antisera directed against Connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues
11. Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium
12. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
13. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block
14. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities and osteoblast dysfunction
15. Expression of connexin 43 (Cx43) is critical for normal hematopoiesis
16. Cardiac malformation in neonatal mice lacking connexin43
17. Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development
18. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation
19. High resolution optical mapping reveals conduction slowing in connexin43 deficient mice
20. + channel activity and connexin expression in Cx43-deficient myocytes
21. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: Evidence for chamber-specific molecular determinants of conduction
22. Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping
23. Optical mapping approaches to cardiac electrophysiological functions
24. Invasive cardiac electrophysiology in the mouse: Techniques and applications
25. Unique and shared functions of different connexins in mice
26. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43