Reverse transcription of retroviruses and LTR retrotransposons

Cellular and Molecular Life Sciences

Volumn 58, Issue 9, 2001, Pages 1246-1262

  Wilhelm, M ^a   Wilhelm, F X ^a  

^a CNRS   (France)

Author keywords

IN RT fusion protein; Retrotransposons; Retroviruses; Reverse transcriptase; Saccharomyces cerevisiae; Ty

Indexed keywords

HYBRID PROTEIN; RNA DIRECTED DNA POLYMERASE;

ENZYME ACTIVITY; NONHUMAN; RETROPOSON; RETROVIRUS; REVIEW; RNA REPLICATION; SACCHAROMYCES CEREVISIAE;

PROKARYOTA; SACCHAROMYCES CEREVISIAE; UNIDENTIFIED RETROVIRUS;

EID: 0034858093     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000937     Document Type: Review

References (100)

1. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements
2. Origin and evolution of retroelements based upon their reverse transcriptase sequences
3. Poised for contagion: Evolutionary origins of the infectious abilities of invertebrate retroviruses
4. Retrotransposon reverse transcription
5. Yeast transposable elements
6. Ty element transposition: Reverse transcriptase and virus-like particles
7. Reverse transcriptase activity and Ty RNA are associated with virus-like particles in yeast
8. The functions and relationships of Ty-VLP proteins in yeast reflects those of mammalian retroviral proteins
9. The DNA intermediate in yeast Ty1 element transposition copurifies with virus-like particles: Cell-free Ty1 transposition
10. Localization of sequences required in cis for yeast Ty1 element transposition near the long terminal repeats: Analysis of mini-Ty1 elements
11. Characterization of products of Ty1-mediated reverse transcription in Saccharomyces cerevisiae
12. Biochemical and electron microscope analyses of the DNA reverse transcripts present in the virus-like particles of the yeast transposon Ty1. Identification of a second origin of Ty1 DNA plus-strand synthesis
13. Characterization of active reverse transcriptase and nucleoprotein complexes of the yeast retrotransposon Ty3 in vitro
14. Interaction of p55 reverse transcriptase from the Saccharomyces cerevisiae retrotransposon Ty3 with conformationally distinct nucleic acid duplexes
15. Expression of an active form of recombinant Ty1 reverse transcriptase in Escherichia coli: A fusion protein containing the C-terminal region of the Ty1 integrase linked to the reverse transcriptase-RNase H domain exhibits polymerase and RNase H activities
16. Yeast retrotransposons and tRNAs
17. Priming of HIV replication by tRNA(Lys3): Role of reverse transcriptase
18. Initiator methionine tRNA is essential for Ty1 transposition in yeast
19. tRNAs as primer of reverse transcriptases
20. Primer tRNAs for reverse transcription
21. Hyperprocessing of tRNA by the catalytic RNA of RNase P. Cleavage of a natural tRNA within the mature tRNA sequence and evidence for an altered conformation of the substrate tRNA
22. The yeast retrotransposon Ty5 uses the anticodon stem-loop of the initiator methionine tRNA as a primer for reverse transcription
23. In vitro hyperprocessing of Drosophila tRNAs by the catalytic RNA of RNase P the cloverleaf structure of tRNA is not always stable?
24. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis
25. An unusual mechanism of self-primed reverse transcription requires the RNase H domain of reverse transcriptase to cleave an RNA duplex
26. A complex structure in the mRNA of Tf1 is recognized and cleaved to generate the primer of reverse transcription
27. Reverse transcription of a self-primed retrotransposon requires an RNA structure similar to the U5-IR stem-loop of retroviruses
28. Regulation of initiation of reverse transcription of retroviruses
29. Lys (template/primer) complex
30. Structural basis for the specificity of the initiation of HIV-1 reverse transcription
31. Yeast Ty1 retrotransposon: The minus-strand primer binding site and a cis-acting domain of the Ty1 RNA are both important for packaging of primer tRNA inside virus-like particles
32. Met and genomic RNA of the yeast Ty1 retrotransposon
33. Interactions between Ty1 retrotransposon RNA and the T and D regions of the tRNA(i)(Met) primer are required for initiation of reverse transcription in vivo
34. Multiple molecular determinants for retrotransposition in a primer tRNA
35. The yeast Ty3 retrotransposon contains a 5′-3′ bipartite primer-binding site and encodes nucleocapsid protein NCp9 functionally homologous to HIV-1 NCp7
36. Structural requirements for the binding of tRNA Lys3 to reverse transcriptase of the human immunodeficiency virus type 1
37. Lys
38. His
39. Essential regions of the tRNA primer required for HIV-1 infectivity
40. Lys interactions inhibiting primer utilization by retroviral reverse transcriptases
41. Lys in vitro: Studies of viral RNA molecules mutated in regions that flank the primer binding site
42. First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses
43. Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: Significance for viral replication
44. Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA
45. HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA
46. Roles of the human immuno deficiency virus type 1 nucleocapsid protein in annealing and initiation versus elongation in reverse transcription of viral negative-strand strong-stop DNA
47. The GAG-like protein of the yeast Ty1 retrotransposon contains a nucleic acid chaperone domain analogous to retroviral nucleocapsid proteins
48. Roles of ribonuclease H in reverse transcription
49. Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H
50. Polypurine tract primer generation and utilization by Moloney murine leukemia virus reverse transcriptase
51. Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases
52. HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: Implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA
53. Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase
54. High-frequency deletion between homologous sequences during retrotransposition of Ty elements in Saccharomyces cerevisiae
55. A second origin of DNA plus-strand synthesis is required for optimal immunodeficiency virus replication
56. Plus-strand DNA synthesis of the yeast retrotransposon Ty1 is initiated at two sites, PPT1 next to the 3′ LTR and PPT2 within the pol gene. PPT1 is sufficient for Ty1 transposition
57. Characterization of (+) strand initiation and termination sequences located at the center of the equine infectious anemia virus genome
58. HIV-1 genome nuclear import is mediated by a central DNA flap
59. Analysis of polypurine tract-associated DNA plus-strand priming in vivo utilizing a plant pararetroviral vector carrying redundant ectopic priming elements
60. Effects of 3′ untranslated region mutations on plus-strand priming during Moloney murine leukemia virus replication
61. Selection of optimal polypurine tract region sequences during Moloney murine leukemia virus replication
62. A sequence immediately upstream of the plus-strand primer is essential for plus-strand DNA synthesis of the Saccharomyces cerevisiae Ty1 retrotransposon
63. Identification of a sequence element immediately upstream of the polypurine tract is essential for replication of simian immunodeficiency virus
64. HIV-1 reverse transcription: A brief overview focused on structure-function relationships among molecules involved in initiation of the reaction
65. The primer tRNA sequence is not inherited during Ty1 retrotransposition
66. Plus-strand strong-stop DNA synthesis in retrotransposon Ty1
67. Plus strand strong-stop DNA transfer in yeast Ty retrotransposons
68. Proteolytic processing of pol-TYB proteins from the yeast retrotransposon Ty1
69. Ty1 proteolytic cleavage sites are required for transposition: All sites are not created equal
70. Proteolytic processing of Ty3 proteins is required for transposition
71. Ten-kilodalton domain in Ty3 Gag3-Po13p between PR and RT is dispensable for Ty3 transposition
72. Catalytic features of the recombinant reverse transcriptase of bovine leukemia virus expressed in bacteria
73. RNase H domain mutations affect the interaction between moloney murine leukemia virus reverse transcriptase and its primer-template
74. Reverse transcriptase of mouse mammary tumour virus: Expression in bacteria, purification and biochemical characterization
75. Alternative modes of polymerization distinguish the subunits of equine infectious anemia virus reverse transcriptase
76. Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization
77. Expression and partial purification of enzymatically active recombinant Ty1 integrase in Saccharomyces cerevisiae
78. Human T-cell leukemia virus type 1 reverse transcriptase (RT) originates from the pro and pol open reading frames and requires the presence of RT-RNase H (RH) and RT-RH-Integrase proteins for its activity
79. Ty3 integrase mutants defective in reverse transcription or 3′-end processing of extrachromosomal Ty3 DNA
80. Mutations in nonconserved domains of Ty3 integrase affect multiple stages of the Ty3 life cycle
81. Structural characterization of the avian retrovirus reverse transcriptase and endonuclease domains
82. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 å resolution shows bent DNA
83. Crystal structure at 3.5 å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
84. Structure of covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
85. Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybrids
86. Human immunodeficiency virus type 1 reverse transcriptase: Spatial and temporal relationship between the polymerase and RNase H activities
87. Mechanism and fidelity of HIV reverse transcriptase
88. Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal
89. Reverse transcriptase-RNase H from the human immunodeficiency virus
90. Evolutionary history of reverse transcriptase
91. Functional organization of the retrotransposon Ty from Saccharomyces cerevisiae: Ty protease is required for transposition
92. The genomic RNA in Ty1 virus-like particles is dimeric
93. Ordered interstrand and intrastrand DNA transfer during reverse transcription
94. Retroviral recombination and reverse transcription
95. The first strand transfer during HIV-1 reverse transcription can occur either intramolecularly or intermolecularly
96. Reverse transcription of the yeast Ty1 retrotransposon: The mode of first strand transfer is either intermolecular or intramolecular
97. In vivo Ty1 reverse transcription can generate replication intermediates with untidy ends
98. Replication errors during in vivo Ty1 transposition are linked to heterogeneous RNase H cleavage sites