Analysis of cyclin E and CDK2 in ovarian cancer: Gene amplification and RNA overexpression

International Journal of Cancer

Volumn 75, Issue 1, 1998, Pages 34-39

  Marone, Maria ^a   Scambia, Giovanni ^a   Giannttelli, Cecilia ^a   Ferrandina, Gabriella ^a   Masciullo, Valeria ^a   Bellacosa, Alfonso ^a,b   Benedetti Panici, Pierluigi ^a   Mancuso, Salvatore ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN E;

ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CARCINOGENESIS; FEMALE; GENETIC ANALYSIS; GENETIC LINKAGE; GROWTH REGULATION; HUMAN; MAJOR CLINICAL STUDY; METASTASIS POTENTIAL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ADULT; AGED; CDC2-CDC28 KINASES; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; FEMALE; GENE AMPLIFICATION; HUMANS; MIDDLE AGED; OVARIAN NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RNA;

EID: 0032484533     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980105)75:1<34::AID-IJC6>3.0.CO;2-2     Document Type: Article

References (25)

1. BELLACOSA, A., and 14 OTHERS, Molecular alterations of the AKT2 oncogene in ovarian and breast carcinoma. Int. J. Cancer, 64, 280-285 (1995).
2. BUCKLEY, M.F., SWEENEY, K.J.E., HAMILTON, J.A., SINI, R.L., MANNING, D.L., NICHOLSON, R.L., DE FAZIO, A., WATTS, C.K.W., MUSGROVE, E.A. and SUTHERLAND, K.L., Expression and amplification of cyclin genus in human breast cancer. Oncogene, 8, 2127-2133 (1993).
3. Kipl protein: prognostic implications in primary breast cancer. Nature (Med). 3, 227-230 (1997).
4. CHOMCZYNSKI, P. and SACCHI, N., Single step method of RNA isolation by guanidium-thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159 (1987).
5. COURJAL, F., LOUASON, G., SPEISER, P., KATSAROS, D., ZEILLINGER, R. and THEILLET, C., Cyclin gene amplification and overexpression in breast and ovarian cancers: evidence for selection of cyclin D1 in breast and cyclin E in ovarian tumors. Int. J. Cancer. 69, 247-253 (1996).
6. DEMETRICK, D.J., MATSUMOTO, S., HANNON, C.J., OKAMOTO, K., XIONG, Y., ZHANG, H. and BEACH, D.H., Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). Cancer Genet. Cytogenet., 69, 190-192 (1995).
7. INK4A in ovarian cancer is associated with progression and unfavourable prognosis. Int. J. Cancer, 74, 57-63 (1997).
8. EORTC BREAST CANCER COOPERATIVE GROUP, Revision of the standards for the assessment of hormone receptor in human breast cancer. Europ. J. Cancer, 16, 1515-1517 (1980).
9. KEYOMARSI, K., O'LEARY, N., MOLNAR, G., LEES, E., FINGERT, H.J. and PARDEE, A.B., Cyclin E, a potential prognostic marker for breast cancer. Cancer Res., 54, 380-385 (1994).
10. KEYOMARSI, K. and PARDEE. A.B., Redundant cyclin overexprcssion and gene amplification in breast cancer cells. Proc. nat. Arad. Sci. (Wash.), 90, 1112-1116 (1993).
11. KITAHARA, K., YASUI, W., KUNIYASU, H., YOKOZAKI, H., AKAMA, Y., YUNOTANI, S., HISATSUGU, T. and TAHARA, E., Concurrent amplification of cyclin E and cdk2 genes in colorectal carcinomas. Int. J. Cancer, 62, 25-28 (1995).
12. LEES, E., FAHA, B., DULIC, V., REED, S.I. and HARLOW, E., Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Develop., 6, 1874-1885 (1992).
13. LODA, M., CIJKOR, B., TAM, S.W., LAVIN, P., FIORENTINO, M., DRAETTA, G.F. JESSUP, J.M. and PAGANO, M., Increased proteasome-dependent degradation of cyclin-dependent kinase inhibitor p27 in aggressive colorectal cancer. Nature (Med.), 3, 231-234 (1997).
14. MACLACHLAN, T.K., SANG, N. and GIORDANO, A., Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer. Crit. Rev. Eukaryotic Gene Expression, 5, 127-156 (1995).
15. MASCIULLO, V., SCAMBIA, G., MARONE, M., GIANNTTELLI, C., FERRANDINA, G., BELLACOSA, A., BENEDEITI-PANICI, P. and MANCUSO, S., Altered expression of cyclin D1 and cdk4 genes in ovarian carcinomas. Int. J. Cancer, (1997) in press.
16. MUMBERG, D., HAAS, K., MÖRÖY, T., NIEDENTHAL, R., HEGEMANN, J.H., FUNK, M. and MÜLLER, R., Uncoupling of DNA replication and cell cycle progression by human cyclin E. Oncogene. 13, 2943-2947 (1996).
17. 1-to-S transition. Mol. cell. Biol., 15, 3463-3469 (1995).
18. ROSENBERG, C.L., KIM, H.G., SHOWS, T.B., KRONENBERG, H.M. and ARNOLD, A., Rearrangement and overexprcssion of D11S287E, a candidate oncogcne on chromosome 11q13 in benign parathyroid tumors. Oncogene, 6, 449-453 (1991).
19. SAMBROOK, J., FRITSCH, E.F. and MANIATIS, T., Molecular Cloning. A Laboratory Manual. (2nd ed.), Cold Spring Harbor, New York (1989).
20. SCAMBIA, G., BENEDETTI-PANICI, P., BATTAGLIA, F., FERRANDINA, G., BAIOCCHI, G., GREGGI, S., DE VINCENZO, R. and MANCUSO, S., Significance of epidermal growth factor receptor in advanced ovarian cancer. J. clin. Oncol., 10, 529-535 (1992).
21. SEROV, S.F. and SCULLY, R.E., International histological classification of tumors. Histological typing of ovarian tumors. WHO. Geneva (1979).
22. SHERR, C.J., Cancer cell cycle. Science, 274, 1672-1677 (1996).
23. VAN ROY, N., FORUS, A., MYKLEBOST, O., CHING CHENG, N., VERSTEEG, R. and SPELEMAN, F., Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP. Cancer Genet. Cytogenet., 82, 151-154 (1995).
24. WORLD HEALTH ORGANIZATION. WHO handbook for reporting results of cancer treatment, 48, 16-21 WHO, Geneva (1979).
25. WORSLEY, S.D., PONDER, B.A.J. and DAVIES, B.R., Overexpression of Cyclin D1 in epithelial ovarian cancers. Gynecol. Oncol., 64, 189-195 (1997).