Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II)

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 2, 1998, Pages 231-238

  Tamamura, Hirokazu ^a   Arakaki, Rieko ^b   Funakoshi, Hanae ^a   Imai, Makoto ^a   Otaka, Akira ^a   Ibuka, Toshiro ^a   Nakashima, Hideki ^b   Murakami, Tsutomu ^c   Waki, Michinori ^d   Matsumoto, Akiyoshi ^d   Yamamoto, Naoki ^c   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d SEIKAGAKU CORPORATION   (Japan)

Author keywords

Anti HIV peptide; Low cytotoxicity; T22; Tachyplesin; TW70

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ARGININE; CITRULLINE; DRUG ANALOG; GLUTAMIC ACID; LYSINE; POLYPHEMUSIN II[5 TYROSINE 12 TYROSINE 7 LYSINE]; SYNTHETIC PEPTIDE; TACHYPLESIN; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CELL FUSION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-HIV AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL SURVIVAL; CELLS, CULTURED; CIRCULAR DICHROISM; DNA-BINDING PROTEINS; HIV-1; HUMANS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; PEPTIDES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION;

EID: 0031839563     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)10037-2     Document Type: Article

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