2-36[K4,RYYSA19-23]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake

Regulatory Peptides

Volumn 87, Issue 1-3, 2000, Pages 47-58

  McCrea, Karen ^a   Wisialowski, Todd ^a   Cabrele, Chiara ^b   Church, Bret ^a   Beck Sickinger, Annette ^b   Kraegen, Edward ^a   Herzog, Herbert ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ETH ZURICH   (Switzerland)

Author keywords

Alanine mutants; Chimeric peptides; NPY; PYY

Indexed keywords

NEUROPEPTIDE Y DERIVATIVE; NEUROPEPTIDE Y5 RECEPTOR; PANCREAS POLYPEPTIDE; PEPTIDE; ALANINE; DRUG DERIVATIVE; HYBRID PROTEIN; LIGAND; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; EMBRYO; FEEDING; FEEDING BEHAVIOR; FOOD INTAKE; HUMAN; HUMAN CELL; KIDNEY CELL; LIGAND BINDING; MALE; MUTANT; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL LINE; DRUG EFFECT; EATING; GENETIC TRANSFECTION; GENETICS; METABOLISM; WISTAR RAT;

ALANINE; ANIMALS; CELL LINE; EATING; FEEDING BEHAVIOR; HUMANS; LIGANDS; MALE; NEUROPEPTIDE Y; PEPTIDES; RATS; RATS, WISTAR; RECEPTORS, NEUROPEPTIDE Y; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0033621998     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(99)00108-1     Document Type: Article

References (36)

1. Tatemoto K., Carlquist M., Mutt V. Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 296:1982;659-660.
2. Tatemoto K. Complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA. 79:1982;5485-5489.
3. Kimmel J.R., Hayden L.J., Pollock H.G. Isolation and characterization of a new pancreatic polypeptide hormone. J Biol Chem. 250:1975;9369-9376.
4. Minakata H., Taylor J.W., Walker M.W., Miller R.J., Kaiser E.T. Characterization of amphiphilic secondary structures in neuropeptide Y through the design, synthesis, and study of model peptides. J Biol Chem. 264:1989;7907-7913.
5. Blomqvist A., Herzog H. Y-receptor subtypes - how many more [review]. Trends Neurosci. 20:1997;294-298.
6. Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci USA. 89:1992;5794-5798.
7. Larhammar D., Blomqvist A.G., Yee F., Jazin E., Yoo H., Wahlestedt C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J Biol Chem. 267:1992;10935-10938.
8. Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., Kodukula K., Kienzle B., Seethala R. Cloning and functional expressing of a cDNA encoding a human type 2 neuropeptide Y receptor. J Biol Chem. 270:1995;22661-22664.
9. Lundell L., Blomqvist A.G., Berglund M.M., Schober D.A., Johnson D., Statnick M.A., Gadski R.A., Gehlert D.R., Larhammar D. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J Biol Chem. 270:1995;29123-29128.
10. Hu Y., Bloomquist B.T., Cornfield L.J., DeCarr L.B., Flores-Riveros J.R., Friedman L., Jiang P., Lewis-Higgins L., Sadlowski Y., Schaefer J., Velazquez N., McCaleb M.L. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behaviour. J Biol Chem. 271:1996;26315-26319.
11. Rose P.M., Lynch J.S., Frazier S.T., Fisher S.M., Chung W., Battaglino P., Fahti Z., Leibel R., Fernandes P. Molecular genetic analysis of a human neuropeptide Y receptor - the human homolog of the murine Y5 receptor may be a pseudogene. J Biol Chem. 272:1997;3622-3627.
12. Wahlestedt C., Yanaihara N., Håkanson R. Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul Pept. 13:1986;307-318.
13. 1 receptor agonist. Proc Natl Acad Sci USA. 87:1990;182-186.
14. Gerald C., Walker M.W., Criscione L., et al. A receptor subtype involved in neuropeptide Y-induced food intake. Nature. 372:1996;168-171.
15. Beck-Sickinger A.G., Jung G., Gaida W., Köppen H., Schnorrenberg G., Lang R. Structure/activity relationships of C-terminal neuropeptide Y peptide segments and analogues composed of sequence 1-4 linked to 25-36. Eur J Biochem. 194:1990;449-456.
16. Krstenansky J.L., Owen T.J., Buck S.H., Hagaman K.A., McLean L.R. Centrally truncated and stabilized porcine neuropeptide Y analogues: design, synthesis and mouse brain receptor binding. Proc Natl Acad Sci USA. 86:1989;4377-4381.
17. Dodds H.N., Wienen W., Entzeroth M., Rudolf K., Eberlin W., Engel W., Wieland H.A. Centrally truncated and stabilized porcine neuropeptide Y analogues: design, synthesis and mouse brain receptor binding. J Pharm Exp Ther. 275:1995;136-142.
18. Gal C.S.-L., Valette G., Rouby P.-E., Pellet A., Oury-Donat F., Brossard G., Lespy L., Marty E., Neliat G., de Coinet P., Maffrand J.-P., Le Fur G. SR1208198A, an orally-active and selective neuropeptide Y1 receptor antagonist. FEBS Lett. 362:1995;192-196.
19. Wright J., Bolton G., Creswell M., Downing D., Georgic L., Heffner T., Hodges J., MacKenzie R., Wise L. 8-Amino-6(aryl-sulfonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett. 6:1996;1809.
20. Grouzmann E., Buclin T., Martire M., Cannizzaro C., Dörner B., Razaname A., Mutter M. Characterisation of a selective antagonist of neuropeptide Y at the Y2 receptor - synthesis and pharmacological evaluation of a Y2 antagonist. J Biol Chem. 272:1997;7699-7706.
21. Morgan D.G., Small C.J., Abusnana S., Turton A.M., Gunn I., Heath M., Rossi M., Goldstone A.P., O'Shea D., Meeran K., Ghatei M., Smith D.M., Bloom S. Regul Pept. 75-76:1998;377-382.
22. Daniels A.J., Matthews J.E., Slepetis R.J., Jansen M., Viveros O.H., Tadepalli A., Harrington W., Heyer D., Landavazo A., Leban J.J., Spaltenstein A. High-affinity neuropeptide Y receptor antagonists. Proc Natl Acad Sci USA. 92:1995;9067-9071.
23. 4) receptor. Peptides. 19:1997;537-542.
24. 2 receptors with distinguished conformations. Eur J Biochem. 225:1994;947-958.
25. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein - dye binding. Anal Biochem. 72:1976;248-254.
26. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 1997;Academic Press, San Diego.
27. Munson P.J., Rodbard D. Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem. 107:1980;220-239.
28. Cheng Y.C., Prusoff W.H. Biochem Pharmacol. 22:1973;3099-3108.
29. Grundemar L., Kahl U., Callréus T., Langel Ü., Bienert M., Beyermann M. Ligand binding and functional effects of systematic double D-amino acid residue substituted neuropeptide Y analogs on Y1 and Y2 receptor types. Regul Pept. 62:1996;131-136.
30. 2-like systems. Regul Pept. 75-76:1998;3-8.
31. Monks S.A., Karagianis G., Howlett G.J., Norton R.S. Solution structure of human neuropeptide Y. J Biomol NMR. 8:1996;379-390.
32. Glover I., Haneef I., Pitts J., Wood S., Moss D., Tickle I., Blundell T. Conformational flexibility in a small globular hormone: X-ray analysis of avian pancreatic polypeptide at 0.98-Å resolution. Biopolymers. 22:1983;293-304.
33. Li X., Sutcliffe M.J., Schwartz T.W., Dobson C.M. Biochemistry. 31:1992;1245-1253.
34. 2 receptors. J Biol Chem. 265:1990;11706-11712.
35. Parker R.M.C., Herzog H. Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci. 11:1999;1431-1448.
36. Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics. 41:1997;315-319.