Mutations in SID2, a novel gene in saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase

Genetics

Volumn 159, Issue 1, 2001, Pages 17-33

  Jacobson, Matthew D ^a,b   Muñoz, Claudia X ^b   Knox, Kirstin S ^b   Williams, Beth E ^b   Lu, Lenette L ^b   Cross, Frederick R ^a   Vallen, Elizabeth A ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b SWARTHMORE COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; DNA;

ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; DNA CONTENT; DNA DAMAGE; DNA REPLICATION; FLUORESCENCE ACTIVATED CELL SORTER; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVE MUTANT; YEAST;

ALLELES; ANAPHASE; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL SEPARATION; CHROMOSOMES; CLONING, MOLECULAR; CYTOPLASM; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; FUNGAL PROTEINS; GENE DELETION; GENE LIBRARY; GENETIC COMPLEMENTATION TEST; HYDROXYUREA; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENOTYPE; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; S PHASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STAPHYLOCOCCAL PROTEIN A; TEMPERATURE; TIME FACTORS; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

SACCHAROMYCES CEREVISIAE;

EID: 0034814765     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle
2. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
3. Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein
4. Duplication of spindle plaques and integration of the yeast cell cycle
5. 'Marker swap' plasmids: Convenient tools for budding yeast molecular genetics
6. The yeast Cln3 protein is an unstable activator of Cdc28
7. Specialization and targeting of B-type cyclins
8. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state
9. Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase a
10. Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells
11. CLB5-dependent activation of late replication origins in S. cerevisiae
12. SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae
13. CyclinB-Cdk1 kinase stimulates ORC-and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts
14. CLB5: A novel B cyclin from budding yeast with a role in S phase
15. Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae
16. Cellular responses to DNA damage in yeast
17. DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae
18. A group of interacting yeast DNA replication genes
19. A ten minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of E. coli
20. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system
21. Disruption of six novel yeast genes reveals three genes essential for vegetative growth and one required for growth at low temperatures
22. The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase
23. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis
24. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae
25. The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle
26. Regulation of nuclear localization: A key to a door
27. A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5
28. SICJ
29. Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit
30. A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle
31. Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities
32. Cell cycle control in S. cerevisiae
33. The inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells
34. G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at start in the yeast cell cycle
35. CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication
36. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
37. CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage
38. A genetic system for detection of protein nuclear import and export
39. Preparation of yeast spindle pole bodies
40. Linkage of replication to start by the Cdk inhibitor Sic1
41. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
42. Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis
43. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae
44. The B-type cyclin kinase inhibitor p40S1C1 controls the G1 to S phase transition in S. cerevisiae
45. Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae
46. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
47. Cell cycle control of DNA replication
48. Destruction of the Cdc28/Clb mitotic kinase is not required for the metaphase to anaphase transition in budding yeast
49. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
50. The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase
51. Interaction between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in Saccharomyces cerevisiae
52. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase
53. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
54. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
55. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
56. Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage
57. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint
58. A new family of yeast nuclear pore complex proteins
59. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae
60. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex
61. Mass spectrometric analysis of the anaphase-promoting complex from yeast: Identification of a subunit related to cullins
62. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin
63. CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication