Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 1, 2001, Pages 351-357

  Wenzel, Uwe ^a   Kuntz, Sabine ^a   Daniel, Hannelore ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Institute of Nutritional Sciences   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACACETIN; AURANTIIN; CARRIER PROTEIN; CEFIXIME; CHRYSIN; DIOSMIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; FLAVONOID; GENISTEIN; HYDROGEN COUPLED INTESTINAL PEPTIDE TRANSPORTER 1; PROTEIN TYROSINE KINASE INHIBITOR; QUERCETIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; CELL PH; CELL STRAIN CACO 2; DOSE RESPONSE; DRUG ABSORPTION; DRUG UPTAKE; FOOD; FOOD DRUG INTERACTION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; PRIORITY JOURNAL; PROTON MOTIVE FORCE; PROTON SODIUM EXCHANGE;

CACO-2 CELLS; CARRIER PROTEINS; CEFIXIME; ENZYME INHIBITORS; EPITHELIAL CELLS; FLAVONOIDS; FLUORESCEINS; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SYMPORTERS; TYRPHOSTINS;

EID: 0034813330     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Genistein, a specific inhibitor of tyrosine-specific protein kinases
2. Drug interactions with grapefruit juice
3. Forbidden fruit
4. Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
5. Grapefruit juice-felodipine interaction: Mechanism, predictability, and effect of naringin
6. Grapefruit juice-drug interactions
7. Pharmacokinetics of beta-lactam antibiotics
8. Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors
9. Inadequacy of high K+/nigericin for calibrating BCECF. II. Intracellular pH dependence of the correction
10. Intestinal transport of beta-lactam antibiotics: Analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux
11. Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein
12. Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein
13. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components
14. Influence of dietary components on the gastrointestinal metabolism and transport of drugs
15. Absolute bioavailability of cefixime in man
16. Hyperosmolality inhibits bicarbonate absorption in rat medullary thick ascending limb via a protein-tyrosine kinase-dependent pathway
17. Hyposmolality stimulates Na(+)/H(+) exchange and HCO(3)(-) absorption in thick ascending limb via PI 3-kinase
18. Angiotensin II inhibits HCO-3 absorption via a cytochrome P-450-dependent pathway in MTAL
19. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands
20. Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein
21. Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of Caco-2 cells
22. Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways
23. Drug-grapefruit juice interactions
24. Brush border phosphatidylinositol 3-kinase mediates epidermal growth factor stimulation of intestinal NaCl absorption and Na+/H+ exchange
25. Regulation of apical membrane Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe
26. Effect of bioflavonoids on vincristine transport across blood-brain barrier
27. Active hexose transport across cultured human Caco-2 cells: Characterisation and influence of culture conditions
28. Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance
29. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2
30. Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2
31. A general pattern for substrate recognition by P-glycoprotein
32. Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: A comparison
33. H(+)-Coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics
34. H(+)/Solute-induced intracellular acidification leads to selective activation of apical Na(+)/H(+) exchange in human intestinal epithelial cells
35. Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic
36. Use of a pharmacophore model for the design of EGFR tyrosine kinase ihibiters: Isoflavones and 3-phenyl-4(IH)-quinolones
37. Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis
38. Efflux of dietary flavonoid quercetin 4′-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2
39. Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells
40. Stereoselective uptake of beta-lactam antibiotics by the intestinal peptide transporter
41. Overexpression of csk inhibits acid-induced activation of NHE-3