Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 2, 1999, Pages 705-709

  Sawada, Kyoko ^a   Terada, Tomohiro ^a   Saito, Hideyuki ^a   Hashimoto, Yukiya ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMINO ACID; CARRIER PROTEIN; ESTER; VALACICLOVIR; VALINE;

ARTICLE; BIOAVAILABILITY; CELL CULTURE; CONTROLLED STUDY; ESTERIFICATION; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ACYCLOVIR; AMINO ACIDS; ANIMALS; CARRIER PROTEINS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; LLC-PK1 CELLS; PRODRUGS; RATS; SWINE; TRANSFECTION; VALINE;

EID: 0032695909     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Balimane PV, Tamai I, Guo A, Nakanishi T, Kitada H, Leibach FH, Tsuji A and Sinko PJ (1998) Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir. Biochem Biophys Res Commun 250:246-251.
2. Beauchamp LM, Orr GF, de Miranda P, Burnette T and Krenitsky TA (1992) Amino acid ester prodrugs of acyclovir. Antiviral Chem Chemother 3:157-164.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Daniel H and Herget M (1997) Cellular and molecular mechanisms of renal peptide transport. Am J Physiol 273:F1-F8.
5. Döring F, Walter J, Will J, Föcking M, Boll M, Amasheh S, Clauss W and Daniel H (1998a) Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J Clin Invest 101:2761-2767.
6. Döring F, Will J, Amasheh S, Clauss W, Ahlbrecht H and Daniel H (1998b) Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter. J Biol Chem 273:23211-23218.
7. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V and Leibach FH (1995) Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT1 and PEPT2. J Biol Chem 270:25672-25677.
8. Ganapathy ME, Huang W, Wang H, Ganapathy V and Leibach FH (1998) Valacyclovir: A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun 246:470-475.
9. Han HK, de Vrueh RLA, Rhie JK, Covitz KMY, Smith PL, Lee CP, Oh DM, Sadée W and Amidon GL (1998a) 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res 15:1154-1159.
10. Han HK, Oh DM and Amidon GL (1998b) Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter. Pharm Res 15:1382-1386.
11. Hu M, Subramanian P, Mosberg HI and Amidon GL (1989) Use of the peptide carrier system to improve the intestinal absorption of L-α-methyldopa: Carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-α-methyldopa. Pharm Res 6:66-70.
12. + coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes. J Pharmacol Exp Ther 260:482-486.
13. Leibach FH and Ganapathy V (1996) Peptide transporters in the intestine and the kidney. Anna Rev Nutr 16:99-119.
14. + coupled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes. J Biol Chem 261:14130-14134.
15. Perry CM and Faulds D (1996) Valacyclovir: A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in herpesvirus infections. Drugs 52:754-772.
16. Ramamoorthy S, Liu W, Ma YY, Yang-Feng TL, Ganapathy V and Leibach FH (1995) Proton/peptide cotransporter (PEPT2) from human kidney: Functional characterization and chromosomal localization. Biochim Biophys Acta 1240:1-4.
17. +/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther 275:1631-1637.
18. Saito H, Terada T, Okuda M, Sasaki S and Inui K (1996) Molecular cloning and tissue distribution of rat peptide transporter PEPT2. Biochim Biophys Acta 1280: 173-177.
19. Temple CS, Stewart AK, Meredith D, Lister NA, Morgan KM, Collier ID, Vaughan-Jones RD, Boyd CAR, Bailey PD and Bronk JR (1998) Peptide mimics as substrates for the intestinal peptide transporter. J Biol Chem 273:20-22.
20. +/peptide cotransporter PEPT1: Localization of PEPT1 and transport of β-lactam antibiotics. J Pharmacol Exp Ther 281:1415-1421.
21. 1 cells. Am J Physiol 273:F706-F711.
22. Tsuji A, Tamai I, Nakanishi M and Amidon GL (1990) Mechanism of absorption of the dipeptide α-methyldopa-Phe in intestinal brush-border membrane vesicles. Pharm Res 7:308-309.