Adenovirus gene transfer vectors inhibit growth of lymphatic tumor metastases independent of a therapeutic transgene

Human Gene Therapy

Volumn 12, Issue 13, 2001, Pages 1639-1649

  Korst, R J ^a   Ailawadi, M ^a   Lee, J M ^a   Lee, S ^a   Yamada, R ^a   Mahtabifard, A ^a   Crystal, R G ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYTOSINE DEAMINASE; FLUCYTOSINE; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; ESCHERICHIA COLI; FOOT PAD; GENE CASSETTE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; LYMPH NODE; LYMPH NODE METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NATURAL KILLER CELL; NONHUMAN; TRANSGENE; VIRUS GENE; VIRUS INACTIVATION;

ADENOVIRIDAE; ANIMALS; CELL DIVISION; FLOW CYTOMETRY; GENE THERAPY; GENETIC VECTORS; INTERFERON TYPE II; KILLER CELLS, NATURAL; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MICE; MICE, INBRED C3H; SEQUENCE DELETION; TIME FACTORS; TRANSGENES; TUMOR CELLS, CULTURED;

EID: 0034808150     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340152528138     Document Type: Article

References (47)

1. A first step in the development of gene therapy for colorectal carcinoma: Cloning, sequencing, and expression of Escherichia coli cytosine deaminase
2. Adenovirus vectors for gene delivery
3. Gene transfer by adenovectors
4. A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4
5. Respiratory disease and the adenoviruses
6. Lymph node metastases. Indicators, but not governors of survival
7. Role of E4 in eliciting CD4 T-cell and B-cell responses to adenovirus vectors delivered to murine and nonhuman primate lungs
8. Immune responses to adenovirus and adeno-associated virus in humans
9. Immunosuppression by melanoma cells as a factor in the generation of metastatic disease
10. In situ use of suicide genes for cancer therapy
11. A single intramuscular injection with an adenovirus-expressing IL-12 protects Balb/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice
12. Biology of adenovirus vectors with E1 and E4 deletions deletions for liver-directed gene therapy
13. Gene therapy for cancer
14. Generation of an adenovirus vector lacking E1, E2a, E3 and all of E4 except open reading frame 3
15. Sophisticated strategies for information encounter in the lymph node. The reticular network as a conduit of soluble information and a highway for cell traffic
16. - adenovirus gene transfer vector
17. Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs
18. Modulation of gene expression after replication deficient recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector
19. Epidemiologic investigations with respiratory disease virus RI-67
20. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine
21. -E3 and inactivated E4 by Gal4-TATA promoter replacement
22. Evidence for the systemic delivery of a transgene product from salivary glands
23. Gene therapy strategies for tumor antiangiogenesis
24. Adenoviral vectors for gene transfer
25. The inhibitory effect of preoperative immunochemotherapy on the lymph node metastasis of murine MM48 tumor
26. Adenovirus vector-mediated gene transfer to regional lymph nodes
27. Interleukin-2: Developing additional cytokine gene therapies using fibroblasts of dendritic cells to enhance tumor immunity
28. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
29. NK cells mediate the anti-tumor effects of E1-deleted, type 5 adenovirus in a human tumor xenograft model
30. Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver
31. A case for cytokines as effector molecules in the resolution of virus infection
32. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
33. Gene replacement strategies for lung cancer
34. Adenoviridae: The viruses and their replication
35. Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors
36. Pharmacological expression in rat hepatocytes of a gene transferred by an adenovirus vector enabled by a chimeric promoter containing multiple cyclic adenosine monophosphate response elements
37. Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice
38. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws
39. The role of natural killer cells in immune surveillance of cancer
40. Adenoviruses as gene-delivery vehicles
41. Upregulation of class I major histocompatibility antigens by IFN-γ is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo
42. Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs
43. Immune responses to viral antigens versus transgene products in the elimination of recombinant adenovirus-infected hepatocytes in vivo
44. Studies on lymphatic metastasis. I. Primary immunoregulatory role of regional lymph nodes in the establishment of lymphatic metastases