A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 6497-6501

  Brough, Douglas E ^a   Lizonova, Alena ^a   Hsu, Chi ^a   Kulesa, Victoria A ^a   Kovesdi, Imre ^a  

^a GENVEC INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE TRANSFER; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VIRUS REPLICATION;

EID: 0029838375     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.6497-6501.1996     Document Type: Article

References (46)

1. Anderson, K. P., and D. F. Klessig. 1984. Altered mRNA splicing in monkey cells infected with human adenovirus may be responsible for inefficient synthesis of the virion fiber polypeptide. Proc. Natl. Acad. Sci. USA 81:4023-4027.
2. Bridge, E., and G. Ketner. 1989. Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63:631-638.
3. Brough, D. E., C. Hsu, A. Lizonova, and I. Kovesdi. Unpublished data.
4. Brough, D. E., V. Cleghon, and D. F. Klessig. 1992. Construction, characterization, and utilization of cell lines which inducibly express the adenovirus DNA-binding protein. Virology 190:624-634.
5. Brough, D. E., G. Droguett, M. S. Horwitz, and D. F. Klessig. 1993. Multiple functions of the adenovirus DNA-binding protein are required for efficient viral DNA synthesis. Virology 196:269-281.
6. Cleghon, V., A. Piderit, D. E. Brough, and D. F. Klessig. 1993. Phosphorylation of the adenovirus DNA-binding protein and epitope mapping of monoclonal antibodies against it. Virology 197:564-575.
7. Dix, I., and K. N. Leppard. 1993. Regulated splicing of adenovirus type 5 E4 transcripts and regulated cytoplasmic accumulation of E4 mRNA. J. Virol. 67:3226-3231.
8. Engelhardt, J. F., X. Ye, B. Doranz, and J. M. Wilson. 1994. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases immune response in mouse liver. Proc. Natl. Acad. Sci. USA 91:6196-6200.
9. Freyer, G. A., Y. Katoh, and R. J. Roberts. 1984. Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing. Nucleic Acids Res. 12:3503-3519.
10. Halbert, D. N., J. R. Cutt, and T. Shenk. 1985. Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J. Virol. 56:250-257.
11. Hemström, C., K. Nordqvist, U. Pettersson, and A. Virtanen. 1988. Gene product of E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides. J. Virol. 62:3258-3264.
12. Hemström, C., A. Virtanen, E. Bridge, G. Ketner, and U. Petlersson. 1991. Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition. J. Virol. 65:1440-1449.
13. Hirt, B. 1967. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:365-369.
14. Huang, M. M., and P. Hearing. 1989. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. J. Virol. 63:2605-2615.
15. Huang, M. M., and P. Hearing. 1989. The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex. Genes Dev. 3:1699-1710.
16. Javier, R., K. Raska, Jr., G. J. Macdonald, and T. Shenk. 1991. Human adenovirus type 9-induced rat mammary tumors. J. Virol. 65:3192-3203.
17. Javier, R., K. Raska, Jr., and T. Shenk. 1992. Requirement for the adenovirus type 9 E4 region in production of mammary tumors. Science 257:1267-1271.
18. Javier, R. T. 1994. Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats. J. Virol. 68:3917-3924.
19. Ketner, G., E. Bridge, A. Virtanen, C. Hemström, and U. Pettersson. 1989. Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids. Nucleic Acids Res. 17:3037-3048.
20. Kleinberger, T., and T. Shenk. 1993. Adenovirus E4orf4 protein hinds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription. J. Virol. 67:7556-7560.
21. Klessig, D. F. 1977. Isolation of a variant of human adenovirus serotype 2 that multiplies efficiently in monkey cells. J. Virol. 21:1243-1246.
22. Klessig, D. F., D. E. Brough, and V. Cleghon. 1984. Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell. Mol. Cell. Biol. 4:1354-1362.
23. Kovesdi, I., R. Reichel, and J. R. Nevins. 1986. E1A transcription induction: enhanced binding of a factor to upstream promoter sequences. Science 231:719-722.
24. Kovesdi, I., R. Reichel, and J. R. Nevins. 1986. Identification of a cellular transcription factor involved in E1A trans-activation. Cell 45:219-228.
25. Krougliak, V., and F. L. Graham. 1995. Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants. Hum. Gene Ther. 6:1575-1586.
26. La Thangue, N. B. 1994. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108-114.
27. Marton, M. J., S. B. Bairn, D. A. Ornelles, and T. Shenk. 1990. The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA. J. Virol. 64:2345-2359.
28. Müller, U., T. Kleinberger, and T. Shenk. 1992. Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1. J. Virol. 66:5867-5878.
29. Neill, S. D., C. Hemström, A. Virtanen, and J. R. Nevins. 1990. An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc. Natl. Acad. Sci. USA 87:2008-2012.
30. Nordqvist, K., and G. Akusjärvi. 1990. Adenovirus early region 4 stimulates mRNA accumulation via 5′ introns. Proc. Natl. Acad. Sci. USA 87:9543-9547.
31. Nordqvist, K., K. Ohman, and G. Akusjärvi. 1994. Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs. Mol. Cell. Biol. 14:437-445.
32. Obert, S., R. J. O'Connor, S. Schmid, and P. Hearing. 1994. The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex. Mol. Cell. Biol. 14:1333-1346.
33. Öhman, K., K. Nordqvist, and G. Akusjärvi. 1993. Two adenovirus proteins with redundant activities in virus growth. Virology 194:50-58.
34. Pilder, S., M. Moore, J. Logan, and T. Shenk. 1986. The adenovirus E1B-55K. transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol. Cell. Biol. 6:470-476.
35. Raychaudhuri, P., S. D. Bagchi, S. Neill, and J. R. Nevins. 1990. Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product. J. Virol. 64:2702-2710.
36. Rice, S. A., and D. F. Klessig. 1984. The function(s) provided by the adenovirus-specified, DNA-binding protein required for viral late gene expression is independent of the role of the protein in viral DNA replication. J. Virol. 49:35-49.
37. Richardson, W. D., and H. Westphal. 1981. A cascade of adenovirus early functions is required for expression of adeno-associated virus. Cell 27:133-141.
38. Sandier, A. B., and G. Keiner. 1989. Adenovirus early region 4 is essential for normal stability of late nuclear RNAs. J. Virol. 63:624-630.
39. Stewart, P. L., R. M. Burnett, M. Cryklaff, and S. D. Fuller. 1991. Image reconstruction reveals the complex molecular organization of the adenovirus. Cell 67:145-154.
40. Stowe, N. D. 1981. Cloning of a DNA fragment from the left-hand terminus of the adenovirus type 2 genome and its use in site-directed mutagenesis. J. Virol. 37:171-180.
41. Tigges, M. A., and H. J. Raskas. 1984. Splice junctions in adenovirus 2 early region 4 mRNAs: multiple splice sites produce 18 to 24 RNAs. J. Virol. 50:106-117.
42. Virtanen, A., P. Gilardi, A. Näslund, J. M. LeMoullec, U. Pettersson, and M. Perricaudet. 1984. mRNAs from human adenovirus 2 early region 4. J. Virol. 51:822-831.
43. Wang, Q, X.-C. Jia, and M. H. Finer. 1995. A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions. Gene Ther. 2:775-783.
44. Weinberg, D. H., and G. Ketner. 1986. Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression. J. Virol. 57:833-838.
45. Yeh, P., J. F. Dedieu, C. Orsini, E. Vigne, P. Denefle, and M. Perricaudet. 1996. Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J. Virol. 70:559-565.
46. Yew, P. R., X. Liu, and A. J. Berk. 1994. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8:190-202.