Immunohistochemical evaluation of bcl-2 gene family expression in liver of hepatitis C and cirrhotic patients: A novel mechanism to explain the high incidence of hepatocarcinoma in cirrhotics

American Journal of Gastroenterology

Volumn 94, Issue 1, 1999, Pages 178-182

  Frommel, Thomas O ^a   Yong, Sherri ^a   Zarling, Edwin J ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN BCL X;

ANTIBODY SPECIFICITY; ARTICLE; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC RISK; HEPATITIS C; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOMA; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; PRIORITY JOURNAL; RISK ASSESSMENT;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CARCINOMA, HEPATOCELLULAR; GENES, BCL-2; HEPATITIS C; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0032895373     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.1999.00792.x     Document Type: Article

References (20)

1. Beasley R. Hepatitis B virus The major etiology of hepatocellular carcinoma . Cancer. 61:1988;1942-1956.
2. Saito I., Miyamura T., Ohbayashi A., et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA. 87:1990;6547-6549.
3. Gonzalez-Peralta R.P., Davis G.L., Lau J.Y.N. Pathogenic mechanisms of hepatocellular damage in chronic hepatitis C virus infection. J Hepatol. 21:1994;255-259.
4. Simmonds N., Rampton D. Inflammatory bowel disease - A radical view. Gut. 34:1993;865-868.
5. Buckley G. The role of oxygen free radicals in human disease processes. Surgery. 94:1983;407-411.
6. Grisham M., MacDermott R., Deitch E. Oxidant defense mechanisms in the human colon. Inflammation. 14:1990;669-680.
7. Hockenbery D., Oltvai Z., Yin X., et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 75:1993;241-251.
8. Kane D., Sarafian T., Anton R., et al. Bcl-2 inhibition of neural death Decreased generation of reactive oxygen species . Science. 262:1993;1274-1277.
9. Desoize B. Anticancer drug resistance and inhibition of apoptosis. Anticancer Res. 14:1994;2291-2294.
10. Frommel TO, Zarling EJ. Chronic inflammation and cancer: Potential role of Bcl-2 gene family members as regulators of cellular antioxidant status. Med Hyp (in press).
11. Boise L.H., Gottschalk A.R., Quintans J., et al. Bcl-2 and Bcl-2 related proteins in apoptosis regulation. Curr Topics Microbiol Immunol. 200:1995;107-121.
12. White E. Life, death and the pursuit of apoptosis. Genes Dev. 10:1996;1-15.
13. Korsmeyer S.J., Yin X., Oltvai Z.N., et al. Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. Biochim Biophys Acta. 1271:1995;63-66.
14. Ekbom A., Helmick C., Zack M., et al. Ulcerative colitis and colorectal cancer. A population based study. N Engl J Med. 323:1990;1228-1233.
15. Cameron A., Ott B., Payne W. The incidence of adenocarcinoma in columnar-lined (Barrett's) esophagus. N Engl J Med. 313:1985;857-859.
16. Parsonnet J., Hansen S., Rodriguez L., et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 330:1994;1267-1271.
17. Lowenfels A.B., Maisonneuve P., DiMagno E.P., et al. Hereditary pancreatitis and the risk of pancreatic cancer. J Natl Cancer Inst. 89:1997;442-446.
18. Charlotte F., L'Hermine A., Martin N., et al. Immunohistochemical detection of bcl-2 protein in normal and pathological liver. Am J Path. 144:1994;460-465.
19. Zhao M., Zhang N., Economou M., et al. Immunohistochemical detection of bcl-2 in liver lesions Bcl-2 protein is expressed in hepatocellular carcinomas but not in liver cell dysplasia . Histopathology. 25:1994;237-245.
20. Skopelitou A., Hadjiyannakis M., Alexopoulou V., et al. Topographical immunohistochemical expression of Bcl-2 protein in human liver lesions. Anticancer Res. 16:1996;975-978.