Mechanisms of induction of persistent nociception by dynorphin

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 1, 2001, Pages 6-11

  Laughlin, Tinna M ^a   Larson, Alice A ^a   Wilcox, George L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNORPHIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OPIATE;

ANTINOCICEPTION; CHRONIC PAIN; NEUROPROTECTION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; TOXICITY;

ANALGESICS, OPIOID; ANIMALS; DYNORPHINS; HUMANS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, OPIOID;

EID: 0034807661     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Dynorphin A increases substance P release from trigeminal primary afferent C-fibers
2. Involvement of dynorphin A and not substance P in the spinal antianalgesic action of capsaicin against morphine-induced antinociception in mice
3. Competitive and non-competitive NMDA antagonists limit dynorphin A-induced rat hindlimb paralysis
4. Differential sensitivity of recombinant N-methyl-D-aspartate receptor subunits to inhibition by dynorphin
5. Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells
6. Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1-17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus
7. A novel interaction between dynorphin (1-13) and an N-methyl-D-aspartate site
8. Dynorphin is a specific endogenous ligand of the kappa opioid receptor
9. The mechanism of action for the block of NMDA receptor channels by the opioid peptide dynorphin
10. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length
11. Evidence for the corelease of dynorphin and glutamate from rat hippocampal mossy fiber terminals
12. Activity-dependent neuronal plasticity following tissue injury and inflammation
13. 3H]CGP-39653 binding to rat brain membranes
14. Dynorphin A (1-13) neurotoxicity in vitro: Opioid and non-opioid mechanisms in mouse spinal cord neurons
15. Constitutive and inducible nitric oxide synthases after dynorphin-induced spinal cord injury
16. Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons
17. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specifcity, behavioral parameters and opioid receptor binding
18. Enhancement of phagocytosis by dynorphin A in mouse peritoneal macrophages
19. Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons
20. Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy
21. Effects of selective and non-selective kappa-opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurones
22. The opioid peptide dynorphin modulates AMPA and kainate responses in acutely isolated neurons from the dorsal horn
23. Evidence that tolerance and dependence of guinea pig myenteric neurons to opioids is a function of altered electrogenic sodium-potassium pumping
24. Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D-aspartate currents in single rat periaqueductal gray neurons
25. Cytokine involvement in dynorphin-induced allodynia
26. Redox manipulation of NMDA receptors in vivo: Alteration of acute pain transmission and dynorphin-induced allodynia
27. Role of inducible nitric oxide synthase in dynorphin-induced allodynia: A central model of neuropathic pain
28. Spinally administered dynorphin A produces long-lasting allodynia: Involvement of NMDA but not opioid receptors
29. 3-13 reduce rat spinal cord blood flow by non-opioid mechanisms
30. Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function
31. Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats
32. A direct non-opiate interaction of dynorphin-(1-13) with the N-methyl-D-aspartate (NMDA) receptor
33. Demonstration of dynorphin A 1-8 immunoreactive axons contacting spinal cord projection neurons in a rat model of peripheral inflammation and hyperalgesia
34. Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord
35. Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1-13) or MK-801 in a nerve-ligation model of peripheral neuropathy
36. Kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord
37. Spinal release of immunoreactive dynorphin A (1-8) with the development of peripheral inflammation in the rat
38. Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain
39. Selective involvement of kappa opioid and phencyclidine receptors in the analgesic and motor effects of dynorphin-A-(1-13)-Tyr-Leu-Phe-Asn-Gly-Pro
40. Non-opioid effects of dynorphins: Possible role of the NMDA receptor
41. Nonopioid motor effects of dynorphin A and related peptides: Structure dependence and role of the N-methyl-D-aspartate receptor
42. Endogenous opioid regulation of hippocampal function
43. Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: Possible roles in paralysis and neurotoxicity
44. Dynorphin A and related peptides administered intrathecally in the rat: A search for putative kappa opiate receptor activity
45. Dynorphin-induced depression of the dorsal root potential in rat spinal cord: A possible mechanism for potentiation of the C-fiber reflex
46. High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors
47. Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism
48. No evidence for endorphin deficiency in fibromyalgia following investigation of cerebrospinal fluid (CSF) dynorphin A and Met-enkephalin-Arg6-Phe7
49. Single intrathecal injections of dynorphin A or des-Tyrdynorphins produce long-lasting allodyrda in rats: Blockade by MK-801 but not naloxone
50. Nonopiate effects of dynorphin and des-Tyr-dynorphin
51. Potentiation of NMDA receptor-mediated responses by dynorphin at low extracellular glycine concentrations
52. Pre-emptive intrathecal MK-801, a non-competitive N-methyl-D-aspartate receptor antagonist, inhibits the up-regulation of spinal dynorphin mRNA and hyperalgesia in a rat model of chronic inflammation