Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D- aspartate currents in single rat periaqueductal gray neurons

Neuroscience Letters

Volumn 247, Issue 2-3, 1998, Pages 115-118

  Lai, Shung Lon ^a   Gu, Yanping ^b   Huang, Li Yen Mae ^b,c  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Opioid; Dynorphin; Excitatory opioid action; N Methyl D aspartate receptor; Non opioid; Periaqueductal gray

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; DYNORPHIN; DYNORPHIN A; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MEMBRANE CURRENT; NERVE CELL EXCITABILITY; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SYNAPTIC TRANSMISSION;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ACTION POTENTIALS; ANALGESICS, NON-NARCOTIC; ANIMALS; DRUG SYNERGISM; DYNORPHINS; N-METHYLASPARTATE; NALOXONE; NALTREXONE; NARCOTIC ANTAGONISTS; NEURONS; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PERIAQUEDUCTAL GRAY; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, OPIOID, KAPPA;

EID: 0032524331     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00293-6     Document Type: Article

References (24)

1. Bakshi R., Ni R.-X., Faden A.I. N-Methyl-D-aspartate (NMDA) and opioid receptors mediate dynorphin-induced spinal cord injury: behavioral and histological studies. Brain Res. 580:1992;255-264.
2. Brauneis U., Oz M., Peoples R.W., Weight F.F., Zhang L. Differential sensitivity of recombinant N-methyl-D-aspartate receptor subunits to inhibition by dynorphin. J. Pharmacol. Exp. Ther. 279:1996;1063-1068.
3. Caudle R.M., Chavkin C., Dubner R. κ2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells. J. Neurosci. 14:1994;5580-5589.
4. Chen L., Gu Y., Huang L.-Y.M. The mechanism of action for the block of NMDA receptor channels by the opioid peptide dynorphin. J. Neurosci. 15:1995;4602-4611.
5. Chen L., Gu Y., Huang L.-Y.M. The opioid peptide dynorphin directly blocks NMDA-receptor channels in the rat. J. Physiol. 482:1995;575-581.
6. Chieng B., Christie M.J. Inhibition by opioids acting on μ-receptors of GABAergic and glutamatergic postysynaptic potentials in single rat periaqueductal gray neurones in vitro. Br. J. Pharmacol. 113:1994;303-309.
7. Dubner, R., Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury. In M.R. Bond, J.E. Charlton and C.J. Woolf (Eds.), Proceedings of the VIth World Congress on Pain, Vol. 4, Elsevier, Amsterdam, 1991, pp. 263-276.
8. Fang F.G., Haws C.M., Drasner K., Williamson A., Fields H.L. Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla. Brain Res. 501:1989;116-128.
9. 2+ in isolated spinal trigeminal neurons of rat. Neuron. 6:1991;777-784.
10. Han J.S., Xie G.X. Dynorphin: important mediator for electroacupuncture analgesia in the spinal cord of the rabbit. Pain. 18:1984;367-376.
11. Hooke L.P., He L., Lee N.M. [Des-Tyr1]dynorphin A-(2-17) has naloxone-insensitive antinociceptive effect in the writhing assay. J. Pharmacol. Exp. Ther. 273:1995;802-807.
12. Laughlin T.M., Vanderah T.W., Lashbrook J., Nichols M.L., Ossipov M., Porreca F., Wilcox G.L. Spinally administered dynorphin a produces longlasting allodynia - involvement of NMDA but not opioid receptors. Pain. 72:1997;253-260.
13. Mansour, A. and Watson, S.J., Anatomical distribution of opioid receptors in mammalians: an overview. In A. Hertz (Eds.), Opioids I, Springer-Verlag, Berlin, 1993, pp. 79-105.
14. Randic' M., Cheng G., Kojic L. κ-Opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord. J. Neurosci. 15:1995;6809-6826.
15. Reichling D.B., Kwiat G.C., Basbaum A.I. Anatomy, physiology and pharmacology of the periaqueductal gray contribution to antinociceptive controls. Prog. Brain Res. 77:1988;31-46.
16. Shukla V.K., Bansinath M., Dumont M., Lemaire S. Selective involvement of kappa opioid and phencyclidine receptors in the analgesic and motor effects of dynorphin-A-(1-13)-Tyr-Leu-Phe-Asn-Gly-Pro. Brain Res. 591:1992;176-180.
17. Siegel A., Schubert K.L., Shaikh M.B. Neurotransmitters regulating defensive rage behavior in the cat. Neurosci. Biobehav. Rev. 21:1997;733-742.
18. Stanfa L., Dickenson A. Spinal opioid systems in inflammation. Inflamm. Res. 44:1995;231-241.
19. Stevens C.W., Yaksh T.L. Dynorphin A and related peptides administered intrathecally in the rat: a search for putative kappa opiate receptor activity. J. Pharmacol. Exp. Ther. 238:1986;833-838.
20. Vaccarino A.L., Clemmons H.R., Mader G.J. Jr., Magnusson J.E. A role of periaqueductal grey NMDA receptors in mediating formalin-induced pain in the rat. Neurosci. Lett. 236:1997;117-119.
21. Vanderah T.W., Laughlin T., Lashbrook J.M., Nichols M.L., Wilcox G.L., Ossipov M.H., Malan T.P., Porreca F. Single intrathecal injections of dynorphin a or des-Tyr-dynorphins produce long-lasting allodynia in rats blockade by MK-801 but not naloxone. Pain. 68:1996;275-281.
22. Vaughan C.W., Christie M.J. Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro. J. Physiol. 498:1997;463-472.
23. Xin L., Geller E.B., Liu-Chen L.Y., Chen C., Adler M.W. Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists. J. Pharmacol. Exp. Ther. 282:1997;1055-1063.
24. Zhang L., Peoples R.W., Oz M., Harveywhite J., Weight F.F., Brauneis U. Potentiation of NMDA receptor-mediated responses by dynorphin at low extracellular glycine concentrations. J. Neurophysiol. 78:1997;582-590.