Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 3, 1998, Pages 826-831

  Chen, Li ^a   Huang, Li Yen Mae ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNORPHIN A; DYNORPHIN[1-10]; DYNORPHIN[1-13]; DYNORPHIN[1-32]; DYNORPHIN[1-8]; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMIDATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; RECEPTOR AFFINITY; TRIGEMINAL NERVE; VOLTAGE CLAMP;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; DYNORPHINS; MOLECULAR SEQUENCE DATA; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031888643     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Arvidsson U, Riedl M, Chakrabarti S, Lee JH, Nakano AH, Dado RJ, Loh HH, Law PY, Wessendorf MW and Elde R (1995a) Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord. J Neurosci 15:3328-3341.
2. Arvidsson U, Riedl M, Chakrabarti S., Vulchanova L, Lee JH, Nakano AH, Lin XQ, Loh HH, Law PY, Wessendorf MW and Elde R (1995b) The kappa-opioid receptor is primarily postsynaptic - combined immunohistochemical localization of the receptor and endogenous opioids. Proc Natl Acad Sci USA 92:5062-5066.
3. Battaglia G and Rustioni A (1988) Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey. J Comp Neurol 277:302-312.
4. Bhat RV, Tausk FA, Baraban JM, Mains RE and Eipper BA (1993) Rapid increases in peptide processing enyzme expression in hippocampal neurons. J Neurochem 61:1315-1322.
5. Caudle RM and Isaac L (1988) Influence of dynorphin (1-13) on spinal reflexes in the rat. J Pharmacol Exp Ther 246:508-513.
6. Chen L, Gu Y and Huang L-YM (1995a) The mechanism of action for the block of NMDA receptor channels by the opioid peptide dynorphin. J Neurosci 15:4602-4611
7. Chen L, Gu Y and Huang L-YM (1995b) The opioid peptide dynorphin directly blocks NMDA-receptor channels in the rat. J Physiol 482:575-581.
8. Cone RI, Weber E, Barchas JD and Goldstern A (1983) Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary. J Neurosci 3:2146-2152.
9. 1-9 are ligands for the κ-subtype of opiate receptor. Nature 299:79-81.
10. Cruz L and Basbaum AI (1985) Multiple opioid peptides and the modulation of pain: Imunohistochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat. J Comp Neurol 240:331-348.
11. Devi L, Gupta P and Fricker LD (1991) Subcellular localization, partial purification, and characterization of a dynorphin processing endopeptidase from bovine pituitary. J Neurochem 56:320-329.
12. Dickerson IM and Noël G (1991) Tissue-specific peptide processing, in Peptide Biosynthesis and Processing (Fricker LD ed) pp 71-109, CRC Press, Boca Raton, FL.
13. Faden AI (1990) Opioid and nonopioid mechanism may contribute to dynorphin's pathophysiological actions in spinal cord injury. Ann Neurol 27:67-74.
14. Fricker L and Devi L (1995) Enzymes involved in opioid peptide biosynthesis, in The Pharmacology of Opioid Peptides (Tseng LF ed) pp 87-107, Hardwood Academic Publishers, Amsterdam.
15. 2+ in isolated spinal trigeminal neurons of rat. Neuron 6:777-784.
16. 2+ in trigeminal neurons. J Neurosci 14:4561-4570.
17. Hooke LP, He L and Lee NM (1995) [Des-Tyr1]dynorphin A-(2-17) has naloxone-insensitive antinociceptive effect in the writhing assay. J Pharmacol Exp Ther 273:802-807.
18. Hope PJ, Fleetwood-Walker SM and Michell R (1990) Distinct antinociceptive actions mediated by different opioid receptors in the region of lamina I and laminae II-V of the dorsal horn of the rat. Br J Pharmacol 10:477-483.
19. Huang L-YM (1989) Calcium channels in isolated rat dorsal horn neurones including labelled spinothalamic and trigeminothalamic cells. J Physiol 411:161-177.
20. Hutchison WD, Morton CR and Terenius L (1990) Dynorphin A: in vivo release in the spinal cord of the cat. Brain Res 532:299-306.
21. Hylden JLK, Nahin RL, Traub RJ and Dubner R (1991) Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons. Pain 44:187-193.
22. Kajander KC, Sahara Y, Iadarola MJ and Bennett GJ (1990) Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy. Peptides 11:719-728.
23. Knox RJ and Dickenson AH (1987) Effects of selective and non-selective κ-opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurons. Brain Res 415:21-29.
24. Magnusson KR, Larson AA, Madl JE, Altschuler RA and Beitz AJ (1986) Co-localization of fixative-modified glutamate and glutaminase in neurons of the spinal trigeminal nucleus of the rat: An immunohistochemical and immunoradiochemical analysis. J Comp Neurol 247:477-490.
25. Martin LJ, Blackstone CD, Levey AI, Huganir RL and Price DL (1993) AMPA glutamate receptor subunits are differentially distributed in rat brain. Neuroscience 53:327-358.
26. McKnight AT, Corbett AD and Kosterlitz H (1983) Increase in potencies of opioid peptides after peptidase inhibition. Eur J Pharmacol 86:393-402.
27. Millan MJ (1989) Kappa-opioid receptor-mediated antinociception in the rat. I. Comparison on mu- and kappa-antinociception against noxious thermal, pressure and electrical stimuli. J Pharmacol Exp Ther 251:334-351.
28. Millan MJ (1993) Multiple opioid systems and chronic pain, in Opioids II, Handbook of Experimental Pharmacology, Vol. 104/I (Herz A ed) pp 127-162, Springer-Verlag, Berlin.
29. Nishimori T, Moskowitz MA and Uhl GR (1988) Opioid peptide gene expression in rat trigeminal nucleus caudalis neurons: Normal distribution and effects of trigeminal deafferentation. J Comp Neurol 274:142-150.
30. Ruda MA, Iadarola MJ, Cohen LV and Young WS (1988) In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia. Proc Natl Acad Sci USA 85:622-626.
31. Salt TE and Hill RG (1982) Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli. Brain Res 263:167-171.
32. Siegel SJ, Brose N, Janssen WG, Gasic GP, Jahn R, Heinemann SF and Morrison JH (1994) Regional, cellular, and ultrastrucutral distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus. Proc Natl Acad Sci USA 91:564-568.
33. Sonders M and Weber E (1987) Distribution pattern of metorphamide compared with other opioid peptides from proenkephalin and prodynorphin in the bovine brain. J Neurochem 49:671-680.
34. 5-enkephalin. J Neurosci 16:4162-4173.
35. Tashiro T, Takahashi O, Satoda T, Matsushima R and Mizuno N (1987) Immunohistochemical demonstration of coexistence of enkephalin- and substance P-like immunoreactivities in axonal components in the lumbar segments of cat spinal cord. Brain Res 424:391-395.
36. Vanderah TW, Laughlin T, Lashbrook JM., Nichols ML, Wilcox GL, Ossipov MH, Malan TP and Porreca F (1996) Single intrathecal injections of dynorphin a or des-tyr-dynorphins produce long-lasting allodynia in rats - blockade by MK-801 but not naloxone. Pain 68:275-281.
37. Weihe E, Leibold A, Nohr D and Gauweiler B (1986) Co-existence of prodynorphin-opioid peptides and substance P in primary sensory afferents of guinea-pig. NIDA Res Monogr 75:295-298.
38. Weihe E, Millan MJ, Hollt V, Nohr D and Herz A (1989) Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats. Neuroscience 31:77-95.
39. Willcockson WS, Kim J, Shin HK, Chung JM and Willis WD (1986) Actions of opioids on primate spinothalamic tract neurons. J Neurosci 6:2509-2520.
40. Yaksh TL (1993) The spinal actions of opioids, in Opioids II, Handbook of Experimental Pharmacology, Vol. 104/II (Herz A ed) pp 53-90, Springer-Verlag, Berlin.
41. Zhang K-M, Wang X-M and Mokha SS (1996) Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis). Brain Res 719:229-233.