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Volumn 186, Issue 12, 1997, Pages 1947-1955

The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; THROMBOPOIETIN; WORTMANNIN;

EID: 0031453394     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.12.1947     Document Type: Article
Times cited : (47)

References (36)
  • 1
    • 0026684707 scopus 로고
    • Molecular cloning and characterization ot MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon, I., J.P. Mornon, L. Cocault, M.T. Mitjavila, P. Tambourin, S. Gisselbrecht, and M. Souyri. 1992. Molecular cloning and characterization ot MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. USA. 89:5640-5644.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5640-5644
    • Vigon, I.1    Mornon, J.P.2    Cocault, L.3    Mitjavila, M.T.4    Tambourin, P.5    Gisselbrecht, S.6    Souyri, M.7
  • 2
    • 0027245081 scopus 로고
    • Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal
    • Skoda, R.C., D.C. Seldin, M.K. Chiang, C.L. Peichel, T.F. Vogt, and P. Leder. 1993. Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO (Eur. Mol. Biol. Organ.) J. 12:2645-2653.
    • (1993) EMBO (Eur. Mol. Biol. Organ.) J. , vol.12 , pp. 2645-2653
    • Skoda, R.C.1    Seldin, D.C.2    Chiang, M.K.3    Peichel, C.L.4    Vogt, T.F.5    Leder, P.6
  • 3
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley, T.D., J. Bogenberger, P. Hunt, Y.S. Li, H.S. Lu, F. Martin, M.S. Chang, B. Samal, J.L. Nichol, S. Swift et al. 1994. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell. 77:1117-1124.
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3    Li, Y.S.4    Lu, H.S.5    Martin, F.6    Chang, M.S.7    Samal, B.8    Nichol, J.L.9    Swift, S.10
  • 6
    • 0028786276 scopus 로고
    • The Janus protein tyrosine kinase family and its role in cytokine signaling
    • Ihle, J.N. 1995. The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv. Immunol. 60:1-35.
    • (1995) Adv. Immunol. , vol.60 , pp. 1-35
    • Ihle, J.N.1
  • 7
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J.E., I.M. Kerr, and G.R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 8
    • 0029102815 scopus 로고
    • TPO and IL-3 induce overlapping but distinct protein tyrosine phosphorylation in a myeloid precursor cell line
    • Dorsch, M., P. Fan, J. Bogenberger, and S.P. Goff. 1995. TPO and IL-3 induce overlapping but distinct protein tyrosine phosphorylation in a myeloid precursor cell line. Biochem. Biophys. Res. Commun. 214:424-431.
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 424-431
    • Dorsch, M.1    Fan, P.2    Bogenberger, J.3    Goff, S.P.4
  • 9
    • 0028910991 scopus 로고
    • The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
    • Drachman, J.G., J.D. Griffin, and K. Kaushansky. 1995. The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J. Biol. Chem. 270:4979-4982.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4979-4982
    • Drachman, J.G.1    Griffin, J.D.2    Kaushansky, K.3
  • 10
    • 0028864865 scopus 로고
    • Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells
    • Mu, S.X., M. Xia, G. Elliott, J. Bogenberger, S. Swift, L. Bennett, D.L. Lappinga, R. Hecht, R. Lee, and C.J. Saris. 1995. Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells. Blood. 86:4532-4543.
    • (1995) Blood , vol.86 , pp. 4532-4543
    • Mu, S.X.1    Xia, M.2    Elliott, G.3    Bogenberger, J.4    Swift, S.5    Bennett, L.6    Lappinga, D.L.7    Hecht, R.8    Lee, R.9    Saris, C.J.10
  • 12
  • 13
    • 0029049709 scopus 로고
    • Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and She phosphorylation
    • Gurney, A.L., S.C. Wong, W.J. Henzel, and F. deSauvage. 1995. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and She phosphorylation. Proc. Natl. Acad. Sci. USA. 92:5292-5296.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5292-5296
    • Gurney, A.L.1    Wong, S.C.2    Henzel, W.J.3    DeSauvage, F.4
  • 14
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • Witthuhn, B.A., F.W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura, and J.N. Ihle. 1993. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 74:227-236.
    • (1993) Cell , vol.74 , pp. 227-236
    • Witthuhn, B.A.1    Quelle, F.W.2    Silvennoinen, O.3    Yi, T.4    Tang, B.5    Miura, O.6    Ihle, J.N.7
  • 15
    • 0028180569 scopus 로고
    • JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
    • Quelle, F.W., N. Sato, B.A. Witthuhn, R.C. Inhorn, M. Eder, A. Miyajima, J.D. Griffin, and J.N. Ihle. 1994. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol. Cell. Biol. 14:4335-1341.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4335-11341
    • Quelle, F.W.1    Sato, N.2    Witthuhn, B.A.3    Inhorn, R.C.4    Eder, M.5    Miyajima, A.6    Griffin, J.D.7    Ihle, J.N.8
  • 16
    • 0028301226 scopus 로고
    • Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors
    • DaSilva, L., O.M. Howard, H. Rui, R.A. Kirken, and W.L. Farrar. 1994. Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors. J. Biol. Chem. 269:18267-18270.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18267-18270
    • DaSilva, L.1    Howard, O.M.2    Rui, H.3    Kirken, R.A.4    Farrar, W.L.5
  • 17
    • 0029963565 scopus 로고    scopus 로고
    • Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: Evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
    • Porteu, F., M.C. Rouyez, L. Cocault, L. Benit, M. Charon, F. Picard, S. Gisselbrecht, M. Souyri, and I. Dusanter-Fourt. 1996. Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin. Mol. Cell. Biol. 16:2473-2482.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2473-2482
    • Porteu, F.1    Rouyez, M.C.2    Cocault, L.3    Benit, L.4    Charon, M.5    Picard, F.6    Gisselbrecht, S.7    Souyri, M.8    Dusanter-Fourt, I.9
  • 18
    • 0028956974 scopus 로고
    • Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction
    • Lebrun, J.J., S. Ali, A. Ullrich, and P.A. Kelly. 1995. Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction. J. Biol. Chem. 270:10664-10670.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10664-10670
    • Lebrun, J.J.1    Ali, S.2    Ullrich, A.3    Kelly, P.A.4
  • 19
    • 0028957771 scopus 로고
    • The conserved box 1 motif of cytokine receptors is required for association with JAK kinases
    • Tanner, J.W., W. Chen, R.L. Young, G.D. Longmore, and A.S. Shaw. 1995. The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J. Biol. Chem. 270:6523-6530.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6523-6530
    • Tanner, J.W.1    Chen, W.2    Young, R.L.3    Longmore, G.D.4    Shaw, A.S.5
  • 20
    • 0027400859 scopus 로고
    • Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors
    • Miura, O., J.L. Cleveland, and J.N. Ihle. 1993. Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors. Mol. Cell. Biol. 13:1788-1795.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1788-1795
    • Miura, O.1    Cleveland, J.L.2    Ihle, J.N.3
  • 21
    • 0030900247 scopus 로고    scopus 로고
    • Dissecting the thrombopoietin receptor: Functional elements of the mpl cytoplasmic domain
    • Drachman, J.G., and K. Kaushansky. 1997. Dissecting the thrombopoietin receptor: functional elements of the mpl cytoplasmic domain. Proc. Natl. Acad. Sci. USA. 94:2350-2355.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2350-2355
    • Drachman, J.G.1    Kaushansky, K.2
  • 23
    • 0004237679 scopus 로고
    • Stockton Press, New York
    • Erlich, H.A. 1989. PCR Technology. Stockton Press, New York, pp 61-70.
    • (1989) PCR Technology , pp. 61-70
    • Erlich, H.A.1
  • 24
    • 0028059925 scopus 로고
    • Gene transfer of the interleukin (IL)-2 receptor beta chain into an IL-7-dependent pre-B cell line permits IL-2-driven proliferation: Tyrosine phosphorylation of She is induced by IL-2 but not IL-7
    • Dorsch, M., H. Hock, and T. Diamantstein. 1994. Gene transfer of the interleukin (IL)-2 receptor beta chain into an IL-7-dependent pre-B cell line permits IL-2-driven proliferation: tyrosine phosphorylation of She is induced by IL-2 but not IL-7. Eur. J. Immunol. 24:2049-2054.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2049-2054
    • Dorsch, M.1    Hock, H.2    Diamantstein, T.3
  • 25
    • 0029961364 scopus 로고    scopus 로고
    • The role of Gag in human immunodeficiency virus type 1 virion morphogenesis and early steps of the viral life cycle
    • Reicin, A.S., A. Ohagen, L. Yin, S. Hoglund, and S.P. Goff. 1996. The role of Gag in human immunodeficiency virus type 1 virion morphogenesis and early steps of the viral life cycle. J. Virol. 70:8645-8652.
    • (1996) J. Virol. , vol.70 , pp. 8645-8652
    • Reicin, A.S.1    Ohagen, A.2    Yin, L.3    Hoglund, S.4    Goff, S.P.5
  • 26
    • 0028817880 scopus 로고
    • Jak-STAT signaling induced by the v-abl oncogene
    • Danial, N.N., A. Pernis, and P.B. Rothman. 1995. Jak-STAT signaling induced by the v-abl oncogene. Science. 269: 1875-1877.
    • (1995) Science , vol.269 , pp. 1875-1877
    • Danial, N.N.1    Pernis, A.2    Rothman, P.B.3
  • 27
    • 0027494821 scopus 로고
    • Signal transduction by the high-affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common beta subunit responsible for different signaling
    • Sato, N., K. Sakamaki, N. Terada, K. Arai, and A. Miyajima. 1993. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO (Eur. Mol. Biol. Organ.) J. 12:4181-4189.
    • (1993) EMBO (Eur. Mol. Biol. Organ.) J. , vol.12 , pp. 4181-4189
    • Sato, N.1    Sakamaki, K.2    Terada, N.3    Arai, K.4    Miyajima, A.5
  • 28
    • 0029588429 scopus 로고
    • Thrombopoietin induces activation of at least two distinct signaling pathways
    • Nagata, Y., and K. Todokoro. 1995. Thrombopoietin induces activation of at least two distinct signaling pathways. FEBS Lett. 377:497-501.
    • (1995) FEBS Lett. , vol.377 , pp. 497-501
    • Nagata, Y.1    Todokoro, K.2
  • 29
    • 0029800869 scopus 로고    scopus 로고
    • Tyrosine-599 of the c-mpl receptor is required for She phosphorylation and the induction of cellular differentiation
    • Alexander, W.S., A.B. Maurer, U. Novak, and M. Harrison-Smith. 1996. Tyrosine-599 of the c-mpl receptor is required for She phosphorylation and the induction of cellular differentiation. EMBO (Eur. Mol. Biol. Organ.) J. 15:6531-6540.
    • (1996) EMBO (Eur. Mol. Biol. Organ.) J. , vol.15 , pp. 6531-6540
    • Alexander, W.S.1    Maurer, A.B.2    Novak, U.3    Harrison-Smith, M.4
  • 30
    • 0029983731 scopus 로고    scopus 로고
    • The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during lymphopoiesis
    • Corcoran, A.E., F.M. Smart, R.J. Cowling, T. Crompton, M.J. Owen, and A. Venkitaraman. 1996. The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during lymphopoiesis. EMBO (Eur. Mol. Biol. Organ.) J. 15:1924-1932.
    • (1996) EMBO (Eur. Mol. Biol. Organ.) J. , vol.15 , pp. 1924-1932
    • Corcoran, A.E.1    Smart, F.M.2    Cowling, R.J.3    Crompton, T.4    Owen, M.J.5    Venkitaraman, A.6
  • 31
    • 0028785505 scopus 로고
    • Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the p85 subunit of phospatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
    • Damen, J.E., R.L. Cutler, H. Jiao, T. Yi, and G. Krystal. 1995. Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the p85 subunit of phospatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. J. Biol. Chem. 270:23402-23408.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23402-23408
    • Damen, J.E.1    Cutler, R.L.2    Jiao, H.3    Yi, T.4    Krystal, G.5
  • 32
    • 0029620504 scopus 로고
    • JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone
    • Winston, L.A., and T. Hunter. 1995. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. J. Biol. Chem. 270:30837-30840.
    • (1995) J. Biol. Chem. , vol.270 , pp. 30837-30840
    • Winston, L.A.1    Hunter, T.2
  • 33
    • 15844389026 scopus 로고    scopus 로고
    • Jak2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells
    • Watanabe, S., T. Itoh, and K.-I. Arai. 1996. Jak2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. J. Biol. Chem. 271: 12681-12686.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12681-12686
    • Watanabe, S.1    Itoh, T.2    Arai, K.-I.3
  • 34
    • 0028074204 scopus 로고
    • Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2
    • Zhuang, H., S.V. Patel, T.C. He, S.K. Sonsteby, Z. Niu, and D.M. Wojchowski. 1994. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J. Biol. Chem. 269:21411-21414.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21411-21414
    • Zhuang, H.1    Patel, S.V.2    He, T.C.3    Sonsteby, S.K.4    Niu, Z.5    Wojchowski, D.M.6
  • 35
    • 0028979693 scopus 로고
    • Interaction of the erythropoietin and stem-cell-factor receptors
    • Wu, H., U. Klingmuller, P. Besmer, and H.F. Lodish. 1995. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 377:242-246.
    • (1995) Nature , vol.377 , pp. 242-246
    • Wu, H.1    Klingmuller, U.2    Besmer, P.3    Lodish, H.F.4
  • 36
    • 0025742603 scopus 로고
    • The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts
    • Misra, R.P., V.M. Rivera, J.M. Wang, P. Fan, and M.E. Greenberg. 1991. The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts. Mol. Cell. Biol. 11:4545-4554.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 4545-4554
    • Misra, R.P.1    Rivera, V.M.2    Wang, J.M.3    Fan, P.4    Greenberg, M.E.5


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