Biosynthesis of natural products on modular peptide synthetases

Metabolic Engineering

Volumn 3, Issue 1, 2001, Pages 64-77

  Doekel, Sascha ^a   Marahiel, Mohamed A ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034800552     PISSN: 10967176     EISSN: None     Source Type: Journal    
DOI: 10.1006/mben.2000.0170     Document Type: Review

References (88)

1. Cloning and sequence analysis of an intron-containing domain from a peptide synthetase-encoding gene of the entomopathogenic fungus Metarhizium anisopliae
2. Genetic organization of the yersiniabactin biosynthetic region and construction of avirulent mutants in Yersinia pestis
3. Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis
4. Metabolic diversity in myxobacteria: Identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90
5. Identification of a peptide synthetase involved in the biosynthesis of glycopeptidolipids of Mycobacterium smegmatis
6. Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonribosomal peptide synthetases
7. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
8. Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicolor A3(2)
9. Analysis of the genome of Mycobacterium tuberculosis H37Rv
10. Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S
11. Sequence and analysis of the genetic locus responsible for surfactin synthesis in Bacillus subtilis
12. Multienzymatic non ribosomal peptide biosynthesis: Identification of the functional domains catalysing peptide elongation and epimerisation
13. Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: Molecular characterization of the last structural peptide synthetase gene
14. Engineering of peptide synthetases. Key role of the thioesterase-like domain for efficient production of recombinant peptides
15. When fold is not important: A common structural framework for adenine and AMP binding in 12 unrelated protein families
16. Insertional mutagenesis of a peptide synthetase gene that is responsible for hepatotoxin production in the cyanobacterium Microcystis aeruginosa PCC 7806
17. Dipeptide formation on engineered hybrid peptide synthetases
18. The mycosubtilin synthetase of Bacillus subtilis ATCC6633: A multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase
19. Lysine biosynthesis in Saccharomyces cerevisiae: Mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5
20. Biosurfactants: Moving toward industrial application
21. Identification of genes involved in the sequestration of iron in mycobacteria: The ferric exochelin biosynthetic and uptake pathways
22. Iron acquisition in plague: Modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis
23. The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis
24. Analysis of core sequences in the d-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis
25. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase
26. Dissecting and exploiting intermodular communication in polyketide synthases
27. Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases
28. Coordinate transcription and physical linkage of domains in surfactin synthetase are not essential for proper assembly and activity of the multienzyme complex
29. Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: Linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains
30. Mutational analysis of the N-methyltransferase domain of the multifunctional enzyme enniatin synthetase
31. Bacterial expression of catalytically active fragments of the multifunctional enzyme enniatin synthetase
32. Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N-methyldepsipeptide formation in Fusarium scirpi
33. NMR saturation transfer and line shape analyses of cyclic tetradepsipeptide AM toxin II: Conformational equilibrium with very unequal populations
34. Cloning and characterization of a cyclic peptide synthetase gene from Alternaria alternata apple pathotype whose product is involved in AM-toxin synthesis and pathogenicity
35. Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
36. Thioesterase domain of delta-(1-alpha-aminoadipyl)-l-cysteinyl-d-valine synthetase: Alteration of stereospecificity by site-directed mutagenesis
37. Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts
38. Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis
39. The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: Molecular characterization of three multi-modular peptide synthetases
40. How do peptide synthetases generate structural diversity?
41. A new enzyme superfamily - The phosphopantetheinyl transferases
42. Control of directionality in nonribosomal peptide synthesis. The role of condensation domain in preventing mis-initiation and timing of epimerization
43. Modular peptide synthetases involved in non-ribosomal peptide synthesis
44. sid1, a gene initiating siderophore biosynthesis in Ustilago maydis: Molecular characterization, regulation by iron, and role in phytopathogenicity
45. The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So CE90
46. The tyrocidine biosynthesis operon of Bacillus brevis: Complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
47. Design and application of multimodular peptide synthetases
48. Construction of hybrid peptide synthetases by module and domain fusions
49. The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506
50. Isolation and characterization of sfp: A gene that functions in the production of the lipopeptide biosurfactant, surfactin, in Bacillus subtilis
51. Nonribosomal peptide synthesis and toxigenicity of cyanobacteria
52. rRNA sequences and evolutionary relationships among toxic and nontoxic cyanobacteria of the genus Microcystis
53. Genetic analysis of the peptide synthetase genes for a cyclic heptapeptide microcystin in microcystis spp.
54. Identification of the ATP binding site in tyrocidine synthetase 1 by selective modification with fluorescein 5′-isothiocyanate
55. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin
56. A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome
57. Crystal structure of the surfactin synthetase-activating enzyme sfp: A prototype of the 4′-phosphopantetheinyl transferase superfamily
58. d-Lysergyl peptide synthetase from the ergot fungus Claviceps purpurea
59. Genes encoding synthetases of cyclic depsipeptides, Anabaenopeptilides, in Anabaena strain 90
60. Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis
61. Enzymatic characterisation of the multifunctional enzyme delta-(1-alpha-aminoadipyl)-l-cysteinyl-d-valine synthetase from Streptomyces clavuligerus
62. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
63. The cyclic peptide synthetase catalyzing HC-toxin production in the filamentous fungus Cochliobolus carbonum is encoded by a 15.7-kilobase open reading frame
64. Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization
65. New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca dw4/3-1
66. The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases
67. Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of multifunctional peptide synthetases
68. Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain
69. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
70. Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains
71. Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase
72. The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates
73. Epimerization of the d-valine portion in the biosynthesis of actinomycin D
74. Molecular analysis of the LYS2 gene of Candida albicans: Homology to peptide antibiotic synthetases and the regulation of the alpha-aminoadipate reductase
75. Cloning and heterologous expression of the epothilone gene cluster
76. Peptide cyclization catalyzed by the thioesterase domain of tyrocidine synthetase
77. Heterologous expression in Escherichia coli of the first module of the nonribosomal peptide synthetase for chloroeremomycin, a vancomycin-type glycopeptide antibiotic
78. Evidence for an ergot alkaloid gene cluster in Claviceps purpurea
79. A general approach for identifying and cloning peptide synthetase genes
80. Structure of antipain, a new Sakaguchi-positive product of Streptomyces
81. Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic
82. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame
83. Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases
84. Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase
85. Cloning of a Vibrio cholerae vibriobactin gene cluster: Identification of genes required for early steps in siderophore biosynthesis
86. Analysis of the exochelin locus in Mycobacterium smegmatis: Biosynthesis genes have homology with genes of the peptide synthetase family
87. Exochelin genes in Mycobacterium smegmatis: Identification of an ABC transporter and two non-ribosomal peptide synthetase genes
88. Biosynthesis of enniatin B: Partial purification and characterization of the synthesizing enzyme and studies of the biosynthesis