Exploitation of host factors for efficient infection by Shigella

International Journal of Medical Microbiology

Volumn 291, Issue 4, 2001, Pages 287-298

  Adam, Thomas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cytoskeleton; Host; Invasion; Shigella; Signaling

Indexed keywords

EID: 0034800007     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00132     Document Type: Article

References (114)

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4. Functional analysis of the Shigella flexneri IpaC invasin by insertional mutagenesis
5. Cadherins and catenins: Role in signal transduction and tumor progression
6. Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin
7. The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes
8. Regulation of cell function by Rho family GTPases
9. Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
10. Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization
11. Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
12. Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin
13. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases
14. The talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation
15. GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
16. A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells
17. Entry of Shigella flexneri into HeLa cells: Evidence for directed phagocytosis involving actin polymerization and myosin accumulation
18. Lack of cleavage of IcsA in Shigella flexneri causes aberrant movement and allows demonstration of a cross-reactive eukaryotic protein
19. Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranes
20. Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway
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22. Differential binding of Pseudomonas aeruginosa to normal and cystic fibrosis tracheobronchial mucins
23. Interferon alpha inhibits a Src-mediated pathway necessary for Shigella-induced cytoskeletal rearrangements in epithelial cells
24. Src tyrosine kinase activity down-regulates Rho-dependent responses during Shigella entry into epithelial cells and stress fibre formation
25. SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri
26. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility
27. Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton
28. Association of the myosin-binding subunit of myosin phosphatase and moesin: Dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase
29. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
30. Regional differences in glycoconjugates of intestinal M cells in mice: Potential targets for mucosal vaccines
31. Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate
32. Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility
33. Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri
34. Adhesion and invasion of a mutant Shigella flexneri to an eukaryotic cell line in absence of the 220-kb virulence plasmid
35. Shigella infection of henle intestinal epithelial cells: Role of the host cell
36. IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole
37. Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB
38. The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells
39. Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation
40. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion
41. Vinculin proteolysis unmasks an Acta homolog for actin-based Shigella motility
42. Mucin-related epitopes distinguish M cells and enterocytes in rabbit appendix and Peyer's patches
43. Glycocalyx on rabbit intestinal M cells displays carbohydrate epitopes from Muc2
44. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization
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46. Morphology of rectal mucosa of patients with shigellosis
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48. Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases
49. Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri
50. The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells
51. The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD
52. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells
53. Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri
54. Secretion of Shigella flexneri Ipa invasins on contact with epithelial cells and subsequent entry of the bacterium into cells are growth stage dependent
55. Rho family GTPases control entry of Shigella flexneri into epithelial cells but not intracellular motility
56. Shigella flexneri enters human colonic Caco-2 epithelial cells through the basolateral pole
57. Phosphorylation of ERM proteins at filopodia induced by Cdc42
58. M cells in antigen sampling in mucosal tissues
59. IpgD, a protein secreted by the type III secretion machinery of Shigella flexneri, is chaperoned by IpgE and implicated in entry focus formation
60. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
61. ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts
62. Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90
63. Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
64. Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches a personal and historical perspective
65. Plasmid-associated adherence of Shigella flexneri in a HeLa cell model
66. Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures
67. Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins
68. Unipolar reorganization of F-actin layer at bacterial division and bundling of actin filaments by plastin correlate with movement of Shigella flexneri within HeLa cells
69. Evolutionary relationships among pathogenic and nonpathogenic Escherichia coli strains inferred from multilocus enzyme electrophoresis and mdh sequence studies
70. Multiple independent origins of Shigella clones of Escherichia coli and convergent evolution of many of their characteristics
71. Binding of Shigella to rat and human intestinal mucin
72. Myosin light chain kinase plays an essential role in S. flexneri dissemination
73. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
74. Signal transduction pathways regulating Rho-mediated stress fibre formation: Requirement for a tyrosine kinase
75. Shigella and enteroinvasive Escherichia coli strains are derived from distinct ancestral strains of E. coli
76. Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a
77. Avirulence of rough mutants of Shigella flexneri: Requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane
78. Establishment of unipolar localization of IcsA in Shigella flexneri 2a is not dependent on virulence plasmid determinants
79. Infection of rabbit Peyer's patches by Shigella flexneri: Effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium
80. Role of interleukin-1 in the pathogenesis of experimental shigellosis
81. Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis
82. Cadherin expression is required for the spread of Shigella flexneri between epithelial cells
83. Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation
84. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
85. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
86. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins
87. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
88. CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells
89. A functional role for ezrin during Shigella flexneri entry into epithelial cells
90. Shigella actin-based motility in the presence of truncated vinculin
91. Distribution and spread of colonic lesions in shigellosis: A colonoscopic study
92. Polyphosphoinositides inhibit the interaction of vinculin with actin filaments
93. Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri
94. Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells
95. Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility
96. IpaB, a Shigella flexneri invasin, colocalizes with interieukin-1 beta-converting enzyme in the cytoplasm of macrophages
97. Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin
98. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells
99. Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions
100. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
101. Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: Identification of a vinculin and pp125Fak-binding region
102. Identification of a novel virulence gene, vitA, on the large plasmid of Shigella, involved in invasion and intercellular spreading
103. Expression of ICAM-I on M cells covering isolated lymphoid follicles of the human colon
104. Regulation of O-antigen chain length is required for Shigella flexneri virulence
105. Role of M cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis
106. Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cells
107. rho, a small GTP-binding protein, is essential for Shigella invasion of epithelial cells
108. Contact of Shigella with host cells triggers release of Ipa invasins and is an essential function of invasiveness
109. Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1
110. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Atp2/3 complex
111. Lipopolysaccharide induces actin reorganization and tyrosine phosphorylation of Pyk2 and paxillin in monocytes and macrophages
112. Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins
113. Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility
114. Shigella flexneri induces apoptosis in infected macrophages