Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a

Molecular Microbiology

Volumn 22, Issue 1, 1996, Pages 63-73

  Sandlin, Robin C ^a   Goldberg, Marcia B ^b   Maurelli, Anthony T ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; LIPOPOLYSACCHARIDE; OUTER MEMBRANE PROTEIN;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CELL INVASION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SHIGELLA FLEXNERI;

ACTINS; ANIMALS; BACTERIAL PROTEINS; CARBOHYDRATE SEQUENCE; DNA-BINDING PROTEINS; ESCHERICHIA COLI PROTEINS; HELA CELLS; HEXOSYLTRANSFERASES; HUMANS; L CELLS (CELL LINE); LIGASES; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; O ANTIGENS; PHENOTYPE; SHIGELLA FLEXNERI; TRANSCRIPTION FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; SHIGELLA; SHIGELLA FLEXNERI 2A;

EID: 0029841665     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.1996.tb02656.x     Document Type: Article

References (33)

1. Bernardini, M.L., Mounier, J., d'Hauteville, H., Coquis-Rondon, M., and Sansonetti, P.J. (1989) Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc Natl Acad Sci USA 86: 3867-3871.
2. Cossart, P., and Kocks, C. (1994) The actin-based motility of the facultative intracellular pathogen Listeria monocytogenes. Mol Microbiol 13: 395-402.
3. Gemski, Jr, P., Sheahan, D.G., Washington, O., and Formal, S.B. (1972) Virulence of Shigella flexneri hybrids expressing Escherichia coli somatic antigens. Infect Immun 6: 104-111.
4. Goldberg, M.B., and Theriot, J.A. (1995) Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility. Proc Natl Acad Sci USA 92: 6572-6576.
5. Goldberg, M.B., Parsot, C., Barzu, O., and Sansonetti, P.J. (1993) Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement. J Bacteriol 175: 2189-2196.
6. Goldberg, M.B., Theriot, J.A., and Sansonetti, P.J. (1994) Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent. Infect Immun 62: 5664-5668.
7. Hale, T. L. (1991) Genetic basis of virulence in Shigella species. Microbiol Rev 55: 206-224.
8. Hitchcock, P.J., and Brown, T.M. (1983) Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels. J Bacteriol 154: 269-277.
9. Hromockyj, A.E., and Maurelli, A.T. (1989) Identification of Shigella invasion genes by isolation of temperature-regulated inv::lacZ operon fusions. Infect Immun 57: 2963-2970.
10. Kenne, L., Lindberg, B., Madden, J.K., Lindberg, A.A., and Gemski, P. (1983) Structural studies of the Escherichia coli O-antigen 25. Carbhydr Res 122: 249-256.
11. Klena, J.D., and Schnaitman, C.A. (1993) Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1. Mol Microbiol 9: 393-402.
12. Klena, J.D., Ashford, II, R.S., and Schnaitman, C.A. (1992) Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. J Bacteriol 174: 7297-7307.
13. Kocks, C., Marchand, J.-B., Gouin, E., d'Hauteville, H., Sansonetti, P.J., Carlier, M.-F., and Cossart, P. (1995) The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli, respectively. Mol Microbiol 18: 413-423.
14. LaBrec, E.H., Schneider, H., Magnani, T.J., and Formal, S.B. (1964) Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J Bacteriol 88: 1503-1518.
15. Lasa, I., and Cossart, P. (1996) Actin-based bacterial motility: towards a definition of the minimal requirements. Trends Cell Biol 6: 109-114.
16. Lindberg, A.A., Karnell, A., and Weintraub, A. (1991) The lipopolysaccharide of Shigella bacteria as a virulence factor. Rev Infect Dis 13(Suppl. 4): S279-S284.
17. Maddock, J.R., Alley, M.R.K., and Shapiro, L. (1993) Polarized cells, polar actions. J Bacteriol 175: 7125-7129.
18. Meier, U., and Mayer, H. (1985) Genetic location of genes encoding enterobacterial common antigen. J Bacteriol 163: 756-762.
19. Meier-Dieter, U., Starman, R., Barr, K., Mayer, H., and Rick, P.D. (1990) Biosynthesis of enterobacterial common antigen in Escherichia coli: biochemical characterization of Tn10 insertion mutants defective in enterobacterial common antigen synthesis. J Biol Chem 265: 13490-13497.
20. Meier-Dieter, U., Barr, K., Starman, R., Hatch, L., and Rick, P.D. (1992) Nucleotide sequence of the Escherichia coli rfe gene involved in the synthesis of enterobacterial common antigen. J Biol Chem 267: 746-753.
21. Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
22. Miller, V.L., and Mekalanos, J.J. (1988) A novel suicide vector and its use in construction of insertion mutations: osmo-regulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol 170: 2575-2583.
23. Morona, R., Mavris, M., Fallarino, A., and Manning, P.A. (1994) Characterization of the rfc region of Shigella flexneri. J Bacteriol 176: 733-747.
24. Oaks, E.V., Wingfield, M.E., and Formal, S.B. (1985) Plaque formation by virulent Shigella flexneri. Infect Immun 48: 124-29.
25. Rick, P.D. (1987) Lipopolysaccharide biosynthesis. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology. Neidhardt, F.C., Ingraham, J.L., Low, K.B., Magasanik, K., Schaechter, M., and Umbarger, H.E. (eds). Washington, DC: American Society for Microbiology, pp. 648-662.
26. Rick, P.D., Hubbard, G.L., and Barr, K. (1994) Role of the rfe gene in the synthesis of the O8 antigen in Escherichia coli K-12. J Bacteriol 176: 2877-2884.
27. Sandlin, R.C., Lampel, K.A., Keasler, S.P., Goldberg, M.B., Stolzer, A.L., and Maurelli, A.T. (1995) Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane. Infect Immun 63: 229-237.
28. Sansonetti, P.J., Arondel, J., Fontaine, A., d'Hauteville, H., and Bernardini, M.L. (1991) OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri; vaccine candidates and probes to study the pathogenesis of shigellosis. Vaccine 9: 416-422.
29. Serény, B. (1957) Experimental keratoconjunctivitis shigellosa. Acta Microbiol Acad Sci Hung 4: 367-376.
30. Simmons, D.A.R., and Romanowska, E. (1987) Structure and biology of Shigella flexneri O antigens. J Med Microbiol 23: 289-302.
31. Smith, G.A., Portnoy, D.A., and Theriot, J.A. (1995) Listeria monocytogenes ActA protein is sufficient to direct actin-based motility. Mol Microbiol 17: 945-951.
32. Tsai, C., and Frasch, C.D. (1982) A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. Anal Biochem 119: 115-119.
33. Valvano, M.A. (1992) Diphenylamine increases cloacin DF13 sensitivity in avian septicemic strains of Escherichia coli. Vet Micro 32: 149-161.