New developments in the treatment of ischemia/reperfusion injury

Current Opinion in Investigational Drugs

Volumn 2, Issue 6, 2001, Pages 783-791

  Ondiveeran, H K ^a   Fox Robichaud, A ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Adenosine; Na+ H+ exchange pump inhibitors; Natural therapies; Oxidative stress; S nitrosothiols

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; ADENOSINE RECEPTOR STIMULATING AGENT; ALPHA TOCOPHEROL DERIVATIVE; ANGIOTENSIN RECEPTOR ANTAGONIST; BOSENTAN; BRADYKININ B2 RECEPTOR ANTAGONIST; CANDESARTAN; CARIPORIDE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DARUSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST; GLYCERYL TRINITRATE; ICATIBANT; IRFI 042; LOSARTAN; M 40401; MELATONIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N AMIDINO 1,4 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; NICARAVEN; NICORANDIL; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; NOX 100; PROPOFOL; PROTEIN INHIBITOR; RIG 200; SCHISANDRA CHINENSIS EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CLINICAL TRIAL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE THERAPY; HUMAN; HYPERBARIC OXYGEN; ISCHEMIA; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; REPERFUSION INJURY; REVIEW; STRUCTURE ANALYSIS; TREATMENT OUTCOME;

ANIMALS; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GENE THERAPY; HUMANS; OXYGEN INHALATION THERAPY; PROTON PUMPS; RECEPTORS, ANGIOTENSIN; RECEPTORS, ENDOTHELIN; RECEPTORS, PURINERGIC P1; REPERFUSION INJURY;

EID: 0034794517     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (64)

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2. + exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA
3. + exchange inhibitor, in rabbits
4. 2+ exchange inhibitor, protects against ischemic acute renal failure in mice by inhibiting renal endothelin-1 overproduction
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6. ATP channels
7. 3 agonist reduces ischemic myocardial injury
8. Post-ischemic intraportal adenosine administration protects against reperfusion injury of canine liver
9. Myocardial protection using diadenosine tetraphosphate with pharmacological preconditioning
10. Adenosine attenuates reperfusion-induced apoptotic cell death by modulating expression of bcl-2 and bax proteins
11. Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction
12. Norepinephrine release and ventricular fibrillation in myocardial ischemia/reperfusion: Roles of angiotensin and bradykinin
13. Angiotensin II type 1 receptor blockade with candesartan protects the porcine myocardium from reperfusion-induced injury
14. 1 receptor antagonist candesartan at antihypertensive plasma concentrations reduces damage induced by ischemia-reperfusion
15. Endothelin-A receptor antagonist BQ123 protects against myocardial and endothelial reperfusion injury
16. Endothelin-A and -B antagonists protect myocardial and endothelial function after ischemia/reperfusion in a rat heart transplantation model
17. Endothelin receptor antagonist improves pulmonary hemodynamics during lung ischemia/reperfusion injury
18. Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts
19. Endothelin receptor antagonist SB209670 decreases lung allograft apoptosis and improves lung graft function after prolonged ischemia
20. Protective effect of the endothelin antagonist bosentan against ischemic skeletal muscle necrosis
21. The novel non-peptide selective endothelin A receptor antagonist LU 135,252 protects against myocardial ischaemic and reperfusion injury in the pig
22. Involvement of nitric oxide in cardioprotective effect of endothelin receptor antagonist during ischemia-reperfusion
23. Inhaled NO as a viable anti-adhesive therapy for ischemia/reperfusion injury of distal microvascular beds
24. Inhaled NO impacts vascular but not extravascular compartments in postischemic peripheral organs
25. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties
26. Reactions between nitric oxide and haemoglobin under physiological conditions
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29. Protective effect of exogenous nitric oxide on the renal function and inflammatory response in a model of ischemia-reperfusion
30. NOX 100, a nitric oxide scavenger, enhances cardiac allograft survival and promotes long-term graft acceptance
31. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
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34. IRFI- 042, a novel dual vitamin E-like antioxidant, inhibits activation of nuclear factor-κB and reduces the inflammatory response in myocardial ischemia-reperfusion injury
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37. Effect of N-acetylcysteine on myocardial infarct size following ischemia and reperfusion in dogs
38. Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion
39. Pretreatment with polynitroxyl albumin (PNA) inhibits ischemia-reperfusion induced leukocyte-endothelial cell adhesion
40. Polynitroxyl albumin plus tempol attenuates liver injury and inflammation after hepatic ischemia and reperfusion
41. Impact of polynitroxylated albumin (PNA) and tempol on ischemia/reperfusion injury: Intravital microscopic study in the dorsal skinfold chamber of the Syrian golden hamster
42. Polynitroxyl-albumin (PNA) plus tempol attenuate lung capillary leak elicited by prolonged intestinal ischemia and reperfusion
43. Significance of melatonin in antioxidative defense system: Reactions and products
44. Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion
45. Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart
46. Improvement in cerebral blood flow and metabolism following subarachnoid hemorrhage in response to prophylactic administration of the hydroxyl radical scavenger, AVS, (±)-N,N-propylenedinicotinamide: A positron emission tomography study in rats
47. Effects of a hydroxyl radical scavenger on delayed ischemic neurological deficits following aneurysmal subarachnoid hemorrhage: Results of a multicenter, placebo-controlled double-blind trial
48. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury
49. Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition
50. Effect of propofol on reperfusion injury after regional ischaemia in the isolated rat heart
51. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway
52. Myocardial protection with red wine extract
53. Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats
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55. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoid constituents and protein kinase C
56. Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts
57. Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status
58. Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats
59. Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: The role of NOS
60. Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats
61. Dual effect of HBO on cerebral infarction in MCAO rats
62. Gene therapy with extracellular superoxide dismutase attenuates myocardial stunning in conscious rabbits
63. Protection from reoxygenation injury by inhibition of rac1
64. Gene therapy for myocardial protection: Transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-reperfusion injury