Protective effect of the endothelin antagonist Bosentan against ischemic skeletal muscle necrosis

Acta Orthopaedica Scandinavica

Volumn 70, Issue 3, 1999, Pages 293-297

  Hvaal, Kjetil ^a,b   Mathisen, Sven R ^a   Svindland, Aud ^b   Nordsletten, Lars ^a,b   Skjeldal, Sigmund ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BOSENTAN; ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOTHESIS; LASER DOPPLER FLOWMETRY; MALE; MORPHOMETRICS; MUSCLE BLOOD FLOW; MUSCLE ISCHEMIA; MUSCLE NECROSIS; NEUTROPHIL; NONHUMAN; RAT; TIBIALIS ANTERIOR MUSCLE; TIME; TOURNIQUET;

EID: 0032774168     PISSN: 00016470     EISSN: None     Source Type: Journal    
DOI: 10.3109/17453679908997811     Document Type: Article

References (19)

1. Chang H, Wu G J, Wang S M, Hung C R. The role of endothelin-1 during ischemia-reperfusion injury. J Formos Med Assoc 1992; 91 (12): 1182-8.
2. Clozel M, Breu V, Gray G A, Kalina B, Loffler B M, Burri K, Cassal J M, Hirth G, Muller M, Neidhart W, et al. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 1994; 270 (1): 228-35.
3. Ekelund U. In vivo effects of endothelin-2, endothelin-3 and ETA receptor blockade on arterial, venous and capillary functions in cat skeletal muscle. Acta Physiol Scand 1994; 150 (1): 47-56.
4. Ekelund U, Adner M, Edvinsson L, Mellander S. Effects of the combined ETA and ETB receptor antagonist PD145065 on arteries, arterioles, and veins in the cat hindlimb. J Cardiovasc Pharmacol (Suppl 3) 1995; 26: 211-3.
5. Elferink J G, de Koster B M. Modulation of human neutrophil chemotaxis by the endothelin-B receptor agonist sarafotoxin S6c. Chem Biol Interact 1996; 101 (3): 165-74.
6. Filep J G, Fournier A, Foldes-Filep E. Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: Involvement of ETA and ETB receptors. Br J Pharmacol 1995; 115 (2): 227-36.
7. Helset E, Lindal S, Olsen R, Myklebust R, Jorgensen L. Endothelin-1 causes sequential trapping of platelets and neutrophils in pulmonary microcirculation in rats. Am J Physiol 1996; 271 (4 Pt 1): L538-46.
8. Hvaal K, Øie E, Attramadal H, Halvorsen V, Svindland A, Nordsletten L, Skjeldal S. Endothelin-1 is upregulated during skeletal muscle ischemia and reperfusion. J Orthop Res 1998; 16 (1): 128-35.
9. Ishizaki T, Shigemori K, Ameshima S, Nakai T, Miyabo S, Hayakawa M, Ozawa T, Voelkel N F. Protective effects of BQ-123, an ETA receptor antagonist, against leukotoxin-induced injury in rat lungs. Am J Physiol 1996; 271 (3 Pt 1): L459-63.
10. Joshua I G. Endothelin-induced vasoconstriction of small resistance vessels in the microcirculation of the rat cremaster muscle. Microvasc Res 1990; 40 (2): 191-8.
11. Khimenko P L, Moore T M, Taylor A E. Blocked ETA receptors prevent ischemia and reperfusion injury in rat lungs. J Appl Physiol 1996; 80 (1): 203-7.
12. Kvernebo K, Staxrud L E, Salerud E G. Assessment of human muscle blood perfusion with single-fiber laser Doppler flowmetry. Microvasc Res 1990; 39 (3): 376-85.
13. McCarron R M, Wang L, Stanimirovic D B, Spatz M. Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells. Neurosci Lett 1993; 156 (1-2): 31-4.
14. Skjeldal S, Grøgaard B, Reikerås O, Muller C, Torvik A, Svindland A. Model for skeletal muscle ischemia in rat hindlimb: evaluation of reperfusion and necrosis. Eur Surg Res 1991; 23 (5-6): 355-65.
15. Skjeldal S, Grøgaard B, Nordsletten L, Reikerås O, Svindland A, Torvik A. Protective effect of low-grade hypothermia in experimental skeletal muscle ischemia. Eur Surg Res 1992; 24 (4): 197-203.
16. Skjeldal S, Torvik A, Grøgaard B, Nordsletten L, Lyberg T. Histological studies on postischemic rat skeletal muscles. With emphasis on the time of leukocyte invasion. Eur Surg Res 1993; 25 (6): 348-57.
17. Skjeldal S, Hvaal K, Nordsletten L, Aasen A O, Reikerås O, Torvik A. Pentoxifylline reduces skeletal muscle necrosis after acute hindlimb ischemia in rats. Eur Surg Res 1994; 26 (2): 94-100.
18. Wang Q D, Li X S, Lundberg J M, Pernow J. Protective effects of non-peptide endothelin receptor antagonist bosentan on myocardial ischaemic and reperfusion injury in the pig. Cardiovasc Res 1995; 29 (6): 805-12.
19. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332 (6163): 411-5.