Roles of chromosomal and episomal dinB genes encoding DNA pol IV in targeted and untargeted mutagenesis in Escherichia coli

Molecular Genetics and Genomics

Volumn 266, Issue 2, 2001, Pages 207-215

  Kim, S R ^a   Matsui, K ^a   Yamada, M ^a   Gruz, P ^a   Nohmi, T ^a  

^a NONE   (Japan)

Author keywords

4 Nitroquinoline N oxide; dinB; DNA polymerase IV; Frameshift mutations; Targeted mutagenesis

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA POLYMERASE; DNA POLYMERASE IV; DNA POLYMERASE V; GUANINE; PROTEIN; PROTEIN DINB; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CHEMICAL MUTAGENESIS; CHROMOSOME; CONTROLLED STUDY; ENZYME INDUCTION; EPISOME; ESCHERICHIA COLI; FRAMESHIFT MUTATION; GENE DELETION; GENE EXPRESSION; GENETIC CODE; INCIDENCE; MUTAGENICITY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; STRAIN DIFFERENCE;

4-NITROQUINOLINE-1-OXIDE; CHROMOSOMES, BACTERIAL; DNA POLYMERASE BETA; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MUTAGENESIS; PLASMIDS; QUINOLONES;

EID: 0034789619     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380100541     Document Type: Article

References (48)

1. Role of RecA protein in untargeted UV mutagenesis of bacteriophage λ: Evidence for the requirement for the dinB gene
2. SOS mutator effect in E. coli mutants deficient in mismatch correction
3. A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions
4. A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations
5. Mutation spectra of the two guanine adducts of the carcinogen 4-nitroquinoline 1-oxide in Escherichia coli. influence of neighboring base sequence on mutagenesis
6. Adaptive mutation: Implications for evolution
7. The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance
8. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
9. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light
10. Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA, and SSB
11. The expanding polymerase universe
12. hRAD30 mutations in the variant form of Xeroderma pigmentosum
13. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Pol η
14. The human DINB1 gene encodes the DNA polymerase Pol θ
15. DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli
16. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: An overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA
17. Identification of a DinB/UmuC homolog in archeon Sulfolobus solfataricus
18. The processing of benzo(a)pyrene adduct into a frameshift or a base substitution mutation requires a different set of genes in Escherichia coli
19. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
20. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
21. Mechanisms of accurate translesion synthesis by human DNA polymerase η
22. Detection of carcinogens as mutagens: Bacterial tester strains with R factor plasmids
23. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism
24. Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase η
25. SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification
26. All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis
27. Deoxycytidyl transferase activity of yeast REV1 protein
28. Error-prone bypass of certain DNA lesions by the human DNA polymerase κ
29. The Y-family of DNA polymerases
30. dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues
31. The Escherichia coli polB locus is identical to dinA, the structural gene for DNA polymerase II. Characterization of Pol II purified from a polB mutant
32. The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replication
33. Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability
34. Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replication polymerase
35. 2C is an error-prone DNA polymerase, Escherichia coli pol V
36. Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis
37. pol ι, a remarkably error-prone human DNA polymerase
38. Inhibition of homologous recombination by the plasmid MucA'B complex
39. Echerichia coli DNA polymerase IV mutator activity: Genetic requirements and mutational specificity
40. The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis
41. The β clamp targets DNA pol IV to DNA and strongly increases its processivity
42. Enhanced generation of A:T→T:A transversions in a recA730 lexA51(Def) mutant of Escherichia coli
43. Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Echerichia coli: I. Frameshift mutagenesis
44. Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli: II. Base substitution mutagenesis
45. Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage
46. 6-methylguanine